Research Paper Volume 12, Issue 23 pp 23889—23899
Cohort profile: the Diet and Healthy Aging (DaHA) study in Singapore
- 1 Department of Psychology, Faculty of Arts and Social Sciences, National University of Singapore, Singapore, Singapore
- 2 Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- 3 Department of Sociology, National University of Singapore, Singapore, Singapore
- 4 Department of Dietetics, National University Hospital, Singapore, Singapore
- 5 Department of Psychological Medicine, National University Hospital, Singapore, Singapore
- 6 Academic Development Department, Duke-NUS Medical School, Singapore, Singapore
- 7 Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- 8 Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- 9 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore
- 10 Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
- 11 Health Promotion Board, Singapore, Singapore
- 12 Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- 13 Department of Neurology, National Neuroscience Institute, Singapore, Singapore
- 14 Department of Medical Education, Research and Evaluation (MERE), Duke-NUS Medical School, Singapore, Singapore
- 15 Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
- 16 Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
- 17 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- 18 Department of Physiology, National University Singapore, Singapore, Singapore
- 19 Singapore Institute of Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
- 20 Centre for Healthy Longevity, National University Health System, Singapore, Singapore
Received: March 18, 2020 Accepted: August 29, 2020 Published: November 18, 2020
https://doi.org/10.18632/aging.104051How to Cite
Copyright: © 2020 Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal study conducted to examine the role of diet and nutrition in promoting cognitive, emotional, and physical health among community-living elderly Singaporeans. The first wave of DaHA, conducted from 2011 to 2017, provided detailed information on diet and baseline cognitive function and health from 1010 community-living elderly in Singapore. Biomarkers of oxidative stress, systemic inflammation, and genetic information were collected. The ongoing second wave of DaHA is conducted from 2017 to 2020, which provides follow- up assessments using established cognitive tests and clinical tools. This well-characterized cohort, with its archived biological samples and high-quality data on diet and lifestyle factors will allow researchers to explore the relationships among diet, nutrition, genes, cognition, mental and physical health in an extremely cost-effective manner. Translations of the research findings into clinical and public health practices will potentially help to promote cognitive health at the population level and reduce healthcare costs related to cognitive impairment.