Research Paper Volume 14, Issue 7 pp 3175—3190

Burden of lymphoma in China, 1990−2019: an analysis of the global burden of diseases, injuries, and risk factors study 2019

Weiping Liu1, *, , Jiangmei Liu2, *, , Yuqin Song1, , Xiaopei Wang1, , Lan Mi1, , Cai Cai3, , Donglu Zhao4, , Lijun Wang2, , Jun Ma4, , Jun Zhu1, ,

  • 1 Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Cancer Hospital and Institute, Beijing, China
  • 2 National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
  • 3 Beijing Institute of Survey and Mapping, Beijing Municipal Key Laboratory of Urban Spatial Information Engineering, Beijing, China
  • 4 Department of Hematology and Oncology, Harbin Institute of Hematology and Oncology, Harbin, China
* Equal contribution and co-first authors

Received: November 27, 2021       Accepted: March 25, 2022       Published: April 10, 2022
How to Cite

Copyright: © 2022 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: China is facing an aggravating disease burden of lymphoma. However, accurate information about lymphoma burden at the national and provincial levels is limited.

Results: The estimated number of disability-adjusted life years were 86,171.85 for Hodgkin lymphoma and 1,306,247.77 for non-Hodgkin lymphoma with the age-standardized rates of 4.95 and 71.00, respectively, per 100,000 population. There were estimated 9,468 new cases and 2,709 Hodgkin lymphoma-related deaths, and 91,954 new cases and 44,310 non-Hodgkin lymphoma-related deaths. Older individuals had a higher lymphoma burden. The age-standardized disability-adjusted life year rate in men was approximately two-folds higher than that in women. Moreover, disparities in lymphoma burden were observed across the provinces. Between 1990 and 2019, the disability-adjusted life year number decreased by 57.8% for Hodgkin lymphoma, and increased by 100.9% for non-Hodgkin lymphoma.

Conclusion: Burden of lymphoma showed heterogeneous change patterns varied according to sex, age, and provinces, with a steady decrease in Hodgkin lymphoma and a significant increase in non-Hodgkin lymphoma during the past three decades.

Methods: Following the analytical strategy used in the Global Burden of Diseases, Injuries, and Risk Factors Study 2019, age-, sex-, and province-specific incidence, mortality, and prevalence of Hodgkin lymphoma and non-Hodgkin lymphoma were analyzed. Lymphoma burden was assessed by incidence, mortality, prevalence, and disability-adjusted life year.


ASIR: age-standardized incidence rates; ASMR: age-standardized mortality rates; DALYs: disability-adjusted life-years; GBD: Global Burden of Diseases, Injuries, and Risk Factors; HL: Hodgkin lymphoma; NHL: non-Hodgkin lymphoma; OS: overall survival; SDI: sociodemographic index; UI: uncertainty interval.