Research Paper Volume 14, Issue 12 pp 5271—5291
Molecular subtypes, prognostic and immunotherapeutic relevant gene signatures mediated by DNA methylation regulators in hepatocellular carcinoma
Figure 2. Identification of DNA methylation regulator-related molecular subtypes in hepatocellular carcinoma. (A) The protein-protein interactions (PPI) network between DNA methylation regulators using STRING database. (B) A network was used to visualize the prognostic significance and expression correlation among these regulators. (C) The correlation between DNA methylation regulator expression and immune cell infiltration levels. (D) The hierarchical clustering of 20 DNA methylation regulators among three molecular subtypes. (E) Survival analyses for three distinct DNA methylation regulator-related molecular subtypes. (F) DNA methylation regulators expressed in the three molecular subtypes. All data analyses were based on the TCGA-LIHC cohort. Neg, negative; Pos, positive; Ns, not significant. *P < 0.05; **P < 0.01; ***P < 0.001.