Research Paper Volume 14, Issue 12 pp 5271—5291
Molecular subtypes, prognostic and immunotherapeutic relevant gene signatures mediated by DNA methylation regulators in hepatocellular carcinoma
Figure 4. Construction of prognosis-related DMS signature. (A) Consensus matrices of DNA methylation subtype-related genes. for k=3. (B) Survival analyses for three distinct Gene.clusters. (C) The hierarchical clustering of1037 overlapping differentially expressed genes among three Gene.clusters. (D) Difference in the 20 DNA methylation regulator expression among three Gene.clusters. (E) The alluvial diagram showing the changes of sample attributes including methylation regulator-related molecular subtypes, Gene.cluster, survival status and DMS. (F) Differences in DMS score across three Gene.clusters. (G) Differences in DMS score across three distinct methylation regulator-related molecular subtypes. All data analyses were based on the TCGA-LIHC cohort. Neg, negative; Pos, positive; Ns, not significant. *P < 0.05; **P < 0.01; ***P < 0.001.