The association between telomere length and mortality in Bangladesh

Samantha G. Dean; Chenan Zhang; Jianjun Gao; Shantanu Roy; Justin Shinkle; Mekala Sabarinathan; Maria Argos; Lin Tong; Alauddin Ahmed; Md. Tariqul Islam; Tariqul Islam; Muhammad Rakibuz-Zaman; Golam Sarwar; Hasan Shahriar; Mahfuzar Rahman; Md. Yunus; Joseph H. Graziano; Lin S. Chen; Farzana Jasmine; Muhammad G. Kibriya; Habibul Ahsan; Brandon L. Pierce

doi:doi:10.18632/aging.101246

Research Paper Volume 9, Issue 6 pp 1537—1551

The association between telomere length and mortality in Bangladesh

Samantha G. Dean^1,, Chenan Zhang^1,2,, Jianjun Gao^3,, Shantanu Roy^1,12,, Justin Shinkle^1,, Mekala Sabarinathan^1,, Maria Argos^4,, Lin Tong^1,, Alauddin Ahmed^5,, Md. Tariqul Islam^5,, Tariqul Islam^5,, Muhammad Rakibuz-Zaman^5,, Golam Sarwar^5,, Hasan Shahriar^5,, Mahfuzar Rahman^6,, Md. Yunus^7,, Joseph H. Graziano^8,, Lin S. Chen^1,, Farzana Jasmine^1,, Muhammad G. Kibriya^1,, Habibul Ahsan^1,9,10,11,, Brandon L. Pierce^1,9,10,,

¹ Department of Public Health Sciences, University of Chicago, Chicago, IL 60637, USA
² Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94158, USA
³ Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
⁴ Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL 60637, USA
⁵ UChicago Research Bangladesh, Dhaka, Bangladesh
⁶ Research and Evaluation Division, BRAC, Dhaka, Bangladesh
⁷ International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
⁸ Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
⁹ Department of Human Genetics, University of Chicago, Chicago, IL 60615, USA
¹⁰ Comprehensive Cancer Center, University of Chicago, Chicago, IL 60615, USA
¹¹ Department of Medicine, University of Chicago, Chicago, IL 60615, USA
¹² Current address: Division of Foodborne, Waterborne, and Environmental Diseases, Center for Disease Control, Atlanta, GA 30333, USA

Received: April 26, 2017 Accepted: May 23, 2017 Published: June 15, 2017

https://doi.org/10.18632/aging.101246
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Dean SG, Zhang C, Gao J, Roy S, Shinkle J, Sabarinathan M, Argos M, Tong L, Ahmed A, Islam MT, Islam T, Rakibuz-Zaman M, Sarwar G, et al, . The association between telomere length and mortality in Bangladesh. Aging (Albany NY). 2017; 9:1537-1551. https://doi.org/10.18632/aging.101246

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Provider: 
        TY  - JOUR
        AU  - Dean, Samantha G. 
        AU  - Zhang, Chenan 
        AU  - Gao, Jianjun 
        AU  - Roy, Shantanu 
        AU  - Shinkle, Justin 
        AU  - Sabarinathan, Mekala 
        AU  - Argos, Maria 
        AU  - Tong, Lin 
        AU  - Ahmed, Alauddin 
        AU  - Islam, Md. Tariqul 
        AU  - Islam, Tariqul 
        AU  - Rakibuz-Zaman, Muhammad 
        AU  - Sarwar, Golam 
        AU  - Shahriar, Hasan 
        AU  - Rahman, Mahfuzar 
        AU  - Yunus, Md. 
        AU  - Graziano, Joseph H. 
        AU  - Chen, Lin S. 
        AU  - Jasmine, Farzana 
        AU  - Kibriya, Muhammad G. 
        AU  - Ahsan, Habibul 
        AU  - Pierce, Brandon L. 
        TI  - The association between telomere length and mortality in Bangladesh
        JO  - 
        JA  - Aging (Albany NY)
        VL  - 9
        IS  - 6
        PB  - 
        SN  - 
        UR  - https://doi.org/10.18632/aging.101246
        DO  - 10.18632/aging.101246
        SP  - 1537
        EP  - 1551
        PY  - 
        AB  - Telomeres are tandem repeat sequences at the end of chromosomes that bind proteins to protect chromosome ends. Telomeres shorten with age, and shorter leukocyte telomere length (TL) has been associated with overall mortality in numerous studies. However, this association has not been tested in populations outside of Europe and the U.S. We assessed the association between TL and subsequent mortality using data on 744 mortality cases and 761 age-/sex-matched controls sampled from &gt;27,000 participants from three longitudinal Bangladeshi cohorts: Health Effects of Arsenic Longitudinal Study (HEALS), HEALS Expansion (HEALS-E), and Bangladesh Vitamin E and Selenium Trial (BEST). We used conditional logistic regression to estimate odds ratios (ORs) for the association between a standardized TL variable and overall mortality, as well as mortality from chronic diseases, respiratory diseases, circulatory diseases, and cancer. In HEALS and BEST, we observed an association between shorter TL and increased overall mortality (P=0.03 and P=0.03), mortality from chronic disease (P=0.01 and P=0.03) and mortality from circulatory disease (P=0.03 and P=0.04). Results from pooled analyses of all cohorts were consistent with HEALS and BEST. This is the first study demonstrating an association between short TL and increased mortality in a population of non-European ancestry.
        ER  -

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Copyright: Dean et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Telomeres are tandem repeat sequences at the end of chromosomes that bind proteins to protect chromosome ends. Telomeres shorten with age, and shorter leukocyte telomere length (TL) has been associated with overall mortality in numerous studies. However, this association has not been tested in populations outside of Europe and the U.S. We assessed the association between TL and subsequent mortality using data on 744 mortality cases and 761 age-/sex-matched controls sampled from >27,000 participants from three longitudinal Bangladeshi cohorts: Health Effects of Arsenic Longitudinal Study (HEALS), HEALS Expansion (HEALS-E), and Bangladesh Vitamin E and Selenium Trial (BEST). We used conditional logistic regression to estimate odds ratios (ORs) for the association between a standardized TL variable and overall mortality, as well as mortality from chronic diseases, respiratory diseases, circulatory diseases, and cancer. In HEALS and BEST, we observed an association between shorter TL and increased overall mortality (P=0.03 and P=0.03), mortality from chronic disease (P=0.01 and P=0.03) and mortality from circulatory disease (P=0.03 and P=0.04). Results from pooled analyses of all cohorts were consistent with HEALS and BEST. This is the first study demonstrating an association between short TL and increased mortality in a population of non-European ancestry.

Research Paper Volume 9, Issue 6 pp 1537—1551

The association between telomere length and mortality in Bangladesh

Received: April 26, 2017 Accepted: May 23, 2017 Published: June 15, 2017

Abstract

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