Volume 9, Issue 6

McCubrey JA, Lertpiriyapong K, Steelman LS, Abrams SL, Yang LV, Murata RM, Rosalen PL, Scalisi A, Neri LM, Cocco L, Ratti S, Martelli AM, Laidler P, et al, . Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. . 9:1477-1536. https://doi.org/10.18632/aging.101250

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                TY  - JOUR
                AU  - McCubrey, James A. 
                AU  - Lertpiriyapong, Kvin 
                AU  - Steelman, Linda S. 
                AU  - Abrams, Steve L. 
                AU  - Yang, Li V. 
                AU  - Murata, Ramiro M. 
                AU  - Rosalen, Pedro L. 
                AU  - Scalisi, Aurora 
                AU  - Neri, Luca M. 
                AU  - Cocco, Lucio 
                AU  - Ratti, Stefano 
                AU  - Martelli, Alberto M. 
                AU  - Laidler, Piotr 
                AU  - Dulińska-Litewka, Joanna 
                AU  - Rakus, Dariusz 
                AU  - Gizak, Agnieszka 
                AU  - Lombardi, Paolo 
                AU  - Nicoletti, Ferdinando 
                AU  - Candido, Saverio 
                AU  - Libra, Massimo 
                AU  - Montalto, Giuseppe 
                AU  - Cervello, Melchiorre 
                TI  - Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101250
                DO  - 10.18632/aging.101250
                SP  - 1477
                EP  - 1536
                PY  - 
                ER  -

Provider: 
                TY  - JOUR
                AU  - McCubrey, James A. 
                AU  - Lertpiriyapong, Kvin 
                AU  - Steelman, Linda S. 
                AU  - Abrams, Steve L. 
                AU  - Yang, Li V. 
                AU  - Murata, Ramiro M. 
                AU  - Rosalen, Pedro L. 
                AU  - Scalisi, Aurora 
                AU  - Neri, Luca M. 
                AU  - Cocco, Lucio 
                AU  - Ratti, Stefano 
                AU  - Martelli, Alberto M. 
                AU  - Laidler, Piotr 
                AU  - Dulińska-Litewka, Joanna 
                AU  - Rakus, Dariusz 
                AU  - Gizak, Agnieszka 
                AU  - Lombardi, Paolo 
                AU  - Nicoletti, Ferdinando 
                AU  - Candido, Saverio 
                AU  - Libra, Massimo 
                AU  - Montalto, Giuseppe 
                AU  - Cervello, Melchiorre 
                TI  - Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101250
                DO  - 10.18632/aging.101250
                SP  - 1477
                EP  - 1536
                PY  - 
                AB  - Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and other health-enhancing effects. A key target of the effects of natural products may be the regulation of microRNA (miR) expression which results in cell death or prevents aging, diabetes, cardiovascular and other diseases. This review will focus on a few natural products, especially on resveratrol (RES), curcumin (CUR) and berberine (BBR). RES is obtained from the skins of grapes and other fruits and berries. RES may extend human lifespan by activating the sirtuins and SIRT1 molecules. CUR is isolated from the root of turmeric (Curcuma longa). CUR is currently used in the treatment of many disorders, especially in those involving an inflammatory process. CUR and modified derivatives have been shown to have potent anti-cancer effects, especially on cancer stem cells (CSC). BBR is also isolated from various plants (e.g., Coptis chinensis) and has been used for centuries in traditional medicine to treat diseases such as adult- onset diabetes. Understanding the benefits of these and other nutraceuticals may result in approaches to improve human health.
                ER  -

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The association between telomere length and mortality in Bangladesh

Samantha G. Dean, Chenan Zhang, Jianjun Gao, Shantanu Roy, Justin Shinkle, Mekala Sabarinathan, Maria Argos, Lin Tong, Alauddin Ahmed, Md. Tariqul Islam, Tariqul Islam, Muhammad Rakibuz-Zaman, Golam Sarwar, Hasan Shahriar, Mahfuzar Rahman, Md. Yunus, Joseph H. Graziano, Lin S. Chen, Farzana Jasmine, Muhammad G. Kibriya, Habibul Ahsan, Brandon L. Pierce,

https://doi.org/10.18632/aging.101246 pp 1537—1551

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Dean SG, Zhang C, Gao J, Roy S, Shinkle J, Sabarinathan M, Argos M, Tong L, Ahmed A, Islam MT, Islam T, Rakibuz-Zaman M, Sarwar G, et al, . The association between telomere length and mortality in Bangladesh. . 9:1537-1551. https://doi.org/10.18632/aging.101246

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                TY  - JOUR
                AU  - Dean, Samantha G. 
                AU  - Zhang, Chenan 
                AU  - Gao, Jianjun 
                AU  - Roy, Shantanu 
                AU  - Shinkle, Justin 
                AU  - Sabarinathan, Mekala 
                AU  - Argos, Maria 
                AU  - Tong, Lin 
                AU  - Ahmed, Alauddin 
                AU  - Islam, Md. Tariqul 
                AU  - Islam, Tariqul 
                AU  - Rakibuz-Zaman, Muhammad 
                AU  - Sarwar, Golam 
                AU  - Shahriar, Hasan 
                AU  - Rahman, Mahfuzar 
                AU  - Yunus, Md. 
                AU  - Graziano, Joseph H. 
                AU  - Chen, Lin S. 
                AU  - Jasmine, Farzana 
                AU  - Kibriya, Muhammad G. 
                AU  - Ahsan, Habibul 
                AU  - Pierce, Brandon L. 
                TI  - The association between telomere length and mortality in Bangladesh
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101246
                DO  - 10.18632/aging.101246
                SP  - 1537
                EP  - 1551
                PY  - 
                ER  -

Provider: 
                TY  - JOUR
                AU  - Dean, Samantha G. 
                AU  - Zhang, Chenan 
                AU  - Gao, Jianjun 
                AU  - Roy, Shantanu 
                AU  - Shinkle, Justin 
                AU  - Sabarinathan, Mekala 
                AU  - Argos, Maria 
                AU  - Tong, Lin 
                AU  - Ahmed, Alauddin 
                AU  - Islam, Md. Tariqul 
                AU  - Islam, Tariqul 
                AU  - Rakibuz-Zaman, Muhammad 
                AU  - Sarwar, Golam 
                AU  - Shahriar, Hasan 
                AU  - Rahman, Mahfuzar 
                AU  - Yunus, Md. 
                AU  - Graziano, Joseph H. 
                AU  - Chen, Lin S. 
                AU  - Jasmine, Farzana 
                AU  - Kibriya, Muhammad G. 
                AU  - Ahsan, Habibul 
                AU  - Pierce, Brandon L. 
                TI  - The association between telomere length and mortality in Bangladesh
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101246
                DO  - 10.18632/aging.101246
                SP  - 1537
                EP  - 1551
                PY  - 
                AB  - Telomeres are tandem repeat sequences at the end of chromosomes that bind proteins to protect chromosome ends. Telomeres shorten with age, and shorter leukocyte telomere length (TL) has been associated with overall mortality in numerous studies. However, this association has not been tested in populations outside of Europe and the U.S. We assessed the association between TL and subsequent mortality using data on 744 mortality cases and 761 age-/sex-matched controls sampled from &gt;27,000 participants from three longitudinal Bangladeshi cohorts: Health Effects of Arsenic Longitudinal Study (HEALS), HEALS Expansion (HEALS-E), and Bangladesh Vitamin E and Selenium Trial (BEST). We used conditional logistic regression to estimate odds ratios (ORs) for the association between a standardized TL variable and overall mortality, as well as mortality from chronic diseases, respiratory diseases, circulatory diseases, and cancer. In HEALS and BEST, we observed an association between shorter TL and increased overall mortality (P=0.03 and P=0.03), mortality from chronic disease (P=0.01 and P=0.03) and mortality from circulatory disease (P=0.03 and P=0.04). Results from pooled analyses of all cohorts were consistent with HEALS and BEST. This is the first study demonstrating an association between short TL and increased mortality in a population of non-European ancestry.
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Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonic development in the pig

Tao Wang, Ying-Ying Gao, Li Chen, Zheng-Wen Nie, Wei Cheng, Xiaoyan Liu, Heide Schatten, Xia Zhang, Yi-Liang Miao,

https://doi.org/10.18632/aging.101252 pp 1552—1564

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Wang T, Gao Y, Chen L, Nie Z, Cheng W, Liu X, Schatten H, Zhang X, Miao Y, . Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonic development in the pig. . 9:1552-1564. https://doi.org/10.18632/aging.101252

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                TY  - JOUR
                AU  - Wang, Tao 
                AU  - Gao, Ying-Ying 
                AU  - Chen, Li 
                AU  - Nie, Zheng-Wen 
                AU  - Cheng, Wei 
                AU  - Liu, Xiaoyan 
                AU  - Schatten, Heide 
                AU  - Zhang, Xia 
                AU  - Miao, Yi-Liang 
                TI  - Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonic development in the pig
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101252
                DO  - 10.18632/aging.101252
                SP  - 1552
                EP  - 1564
                PY  - 
                AB  - Oxidative stress is known as a major contributing factor involved in oocyte aging, which negatively affects oocyte quality and development after fertilization. Melatonin is an effective free radical scavenger and its metabolites AFMK and AMK are powerful detoxifiers that eliminate free radicals. In this study, we used porcine oocytes to test the hypothesis that melatonin could scavenge free radicals produced during oocyte aging, thereby maintaining oocyte quality. We compared reactive oxygen species levels, apoptosis levels, mitochondrial membrane potential ratios, total glutathione contents and expression levels in fresh, aged and melatonin-treated aged porcine oocytes and observed the percentage of blastocyst formation following parthenogenetic activation. We found that melatonin could effectively maintain the morphology of oocytes observed in control oocytes, alleviate oxidative stress, markedly decrease early apoptosis levels, retard the decline of mitochondrial membrane potential and significantly promote subsequent embryonic development in oocytes aged for 24 hr in vitro. These results strongly suggest that melatonin can prevent postovulatory oocyte aging and promote subsequent embryonic development in the pig, which might find practical applications to control oocyte aging in other mammalian species including humans to maintain the quality of human oocytes when performing clinical assisted reproductive technology.
                ER  -

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Identification of an 88-microRNA signature in whole blood for diagnosis of hepatocellular carcinoma and other chronic liver diseases

Xiao-Ran Long, Yao-Jun Zhang, Mei-Yin Zhang, Keng Chen, X.F Steven Zheng, Hui-Yun Wang,

https://doi.org/10.18632/aging.101253 pp 1565—1584

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Long X, Zhang Y, Zhang M, Chen K, Zheng XS, Wang H, . Identification of an 88-microRNA signature in whole blood for diagnosis of hepatocellular carcinoma and other chronic liver diseases. . 9:1565-1584. https://doi.org/10.18632/aging.101253

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                TY  - JOUR
                AU  - Long, Xiao-Ran 
                AU  - Zhang, Yao-Jun 
                AU  - Zhang, Mei-Yin 
                AU  - Chen, Keng 
                AU  - Zheng, X.F Steven 
                AU  - Wang, Hui-Yun 
                TI  - Identification of an 88-microRNA signature in whole blood for diagnosis of hepatocellular carcinoma and other chronic liver diseases
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101253
                DO  - 10.18632/aging.101253
                SP  - 1565
                EP  - 1584
                PY  - 
                AB  - Hepatocellular carcinoma (HCC) is a common cancer with very poor survival due to lack of reliable biomarker for early diagnosis. In this study, we investigated microRNA (miRNA) profile of whole blood with a custom microarray containing probes for 1849 miRNA species in a total 213 successive subjects who were divided into a discovery set and a validation set. An 88-miRNA signature was established to diagnose health controls (HC), chronic hepatitis B (CHB), liver cirrhosis (LC) and HCC with 100% accuracy in the discovery set using Fisher discriminant analysis. This diagnostic signature was confirmed in the validation set with accuracy rates of 100%, 95.2%, 93.7% and 98.4% for HC, CHB, LC and HCC patients, respectively. Compared with AFP, the only available non-invasive and routinely used biomarker for diagnosis of HCC, the 88-miRNA signature has much higher accuracy (99.5% vs 76.5%), sensitivity (100% vs 63.8%), and specificity (99.2% vs 84.2%). More importantly, the signature detects small HCCs (&lt;3cm) with 100% (17/17) accuracy while AFP has only 64.7% (11/17). In conclusion, we have identified a powerful and sensitive blood 88-miRNA signature for diagnosing early HCC and other chronic liver diseases (CHB and LC) with a high accuracy.
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CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630

Yan Zhang, Hao Liu, Wende Li, Jiang Yu, Jin Li, Zhiyong Shen, Gentai Ye, Xiaolong Qi, Guoxin Li,

https://doi.org/10.18632/aging.101254 pp 1585—1594

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Zhang Y, Liu H, Li W, Yu J, Li J, Shen Z, Ye G, Qi X, Li G, . CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630. . 9:1585-1594. https://doi.org/10.18632/aging.101254

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                TY  - JOUR
                AU  - Zhang, Yan 
                AU  - Liu, Hao 
                AU  - Li, Wende 
                AU  - Yu, Jiang 
                AU  - Li, Jin 
                AU  - Shen, Zhiyong 
                AU  - Ye, Gentai 
                AU  - Qi, Xiaolong 
                AU  - Li, Guoxin 
                TI  - CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101254
                DO  - 10.18632/aging.101254
                SP  - 1585
                EP  - 1594
                PY  - 
                AB  - Although CircRNA_100269 is a biomarker used to predict cancer recurrence, its expression and function in gastric cancer (GC) remain unknown. In this study, the expression of circRNA_100269 and its potential downstream miRNA targets were investigated. The molecular function and regulatory mechanism of circRNA_100269 in GC cell lines were also elucidated. The expression levels of circRNA_100269 and its linear isomer LPHN2 mRNA were found to be downregulated (p&lt;0.01) in GC tissues. The target miRNA was predicted to be miR-630, whose expression was upregulated (p&lt;0.01) and found to be negatively correlated with that of circRNA_100269 (r = -0.688) in GC tissues. Moreover, direct interaction of circRNA_100269 and miR-630 was confirmed through dual-luciferase assays. Overexpressing the circRNA_100269 plasmid inhibited cell proliferation (p&lt;0.05). Furthermore, transfection of miR-630 mimics into cell lines overexpressing circRNA_100269 blocked the function of circRNA_100269 (p&lt;0.05). Thus, circRNA_100269 level was downregulated in GC and correlated negatively with that of miR-630. Taken together, our results suggest that circRNA_100269 and miR-630 comprise a novel pathway that regulates proliferation of GC cells.
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Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Quynh Nhu Dinh, Grant R. Drummond, Barbara K. Kemp-Harper, Henry Diep, T. Michael De Silva, Hyun Ah Kim, Antony Vinh, Avril A.B. Robertson, Matthew A. Cooper, Ashley Mansell, Sophocles Chrissobolis, Christopher G. Sobey,

https://doi.org/10.18632/aging.101255 pp 1595—1606

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Dinh QN, Drummond GR, Kemp-Harper BK, Diep H, De Silva TM, Kim HA, Vinh A, Robertson AA, Cooper MA, Mansell A, Chrissobolis S, Sobey CG, . Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress. . 9:1595-1606. https://doi.org/10.18632/aging.101255

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                TY  - JOUR
                AU  - Dinh, Quynh Nhu 
                AU  - Drummond, Grant R. 
                AU  - Kemp-Harper, Barbara K. 
                AU  - Diep, Henry 
                AU  - De Silva, T. Michael 
                AU  - Kim, Hyun Ah 
                AU  - Vinh, Antony 
                AU  - Robertson, Avril A.B. 
                AU  - Cooper, Matthew A. 
                AU  - Mansell, Ashley 
                AU  - Chrissobolis, Sophocles 
                AU  - Sobey, Christopher G. 
                TI  - Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101255
                DO  - 10.18632/aging.101255
                SP  - 1595
                EP  - 1606
                PY  - 
                ER  -

Provider: 
                TY  - JOUR
                AU  - Dinh, Quynh Nhu 
                AU  - Drummond, Grant R. 
                AU  - Kemp-Harper, Barbara K. 
                AU  - Diep, Henry 
                AU  - De Silva, T. Michael 
                AU  - Kim, Hyun Ah 
                AU  - Vinh, Antony 
                AU  - Robertson, Avril A.B. 
                AU  - Cooper, Matthew A. 
                AU  - Mansell, Ashley 
                AU  - Chrissobolis, Sophocles 
                AU  - Sobey, Christopher G. 
                TI  - Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101255
                DO  - 10.18632/aging.101255
                SP  - 1595
                EP  - 1606
                PY  - 
                AB  - Aging is commonly associated with chronic low-grade inflammation and hypertension but it is unknown whether a cause-effect relationship exists between them. We compared the sensitivity of young adult (8-12 w) and aged (23-31 mo) male C57Bl6J mice to develop hypertension in response to a slow-pressor dose of angiotensin II (Ang II; 0.28 mg/kg/d; 28 d). In young mice, the pressor response to Ang II was gradual and increased to 142±8 mmHg over 28 d. However, in aged mice, Ang II promptly increased SBP and reached 155±12 mmHg by 28 d. Aging increased renal but not brain expression of Ang II receptors (At1ar and At2r) and elevated AT1R:AT2R expression ratio in mesenteric artery. Maximal contractile responses of mesenteric arteries to Ang II were enhanced in aged mice and were not affected by L-NAME, indomethacin or tempol. Mesenteric arteries and thoracic aortae from aged mice exhibited higher Nox2-dependent superoxide production. Despite having higher renal expression of Nlrp3, Casp-1 and Il-1β, Ang II-induced hypertension (SBP: 139±7 mmHg) was unaffected by co-infusion of the NLRP3 inflammasome inhibitor, MCC950 (10 mg/kg/d; SBP: 145±10 mmHg). Thus, increased vascular AT1R:AT2R expression, rather than NLRP3 inflammasome activation, may contribute to enhanced responses to Ang II in aging.
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Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory

Simona Foscarin, Ruma Raha-Chowdhury, James W. Fawcett, Jessica C.F. Kwok,

https://doi.org/10.18632/aging.101256 pp 1607—1622

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Foscarin S, Raha-Chowdhury R, Fawcett JW, Kwok JC, . Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory. . 9:1607-1622. https://doi.org/10.18632/aging.101256

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                TY  - JOUR
                AU  - Foscarin, Simona 
                AU  - Raha-Chowdhury, Ruma 
                AU  - Fawcett, James W. 
                AU  - Kwok, Jessica C.F. 
                TI  - Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101256
                DO  - 10.18632/aging.101256
                SP  - 1607
                EP  - 1622
                PY  - 
                AB  - Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer’s disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains of CS proteoglycans, which are mainly sulfated in the 4 (C4S) or 6 (C6S) positions. While C4S is inhibitory, C6S is more permissive to axon growth, regeneration and plasticity. C6S decreases during critical period closure. We asked whether there is a late change in CS-GAG sulfation associated with memory loss in aged rats. Immunohistochemistry revealed a progressive increase in C4S and decrease in C6S from 3 to 18 months. GAGs extracted from brain PNNs showed a large reduction in C6S at 12 and 18 months, increasing the C4S/C6S ratio. There was no significant change in mRNA levels of the chondroitin sulfotransferases. PNN GAGs were more inhibitory to axon growth than those from the diffuse extracellular matrix. The 18-month PNN GAGs were more inhibitory than 3-month PNN GAGs. We suggest that the change in PNN GAG sulfation in aged brains renders the PNNs more inhibitory, which lead to a decrease in plasticity and adversely affect memory.
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Sodium fluoride causes oxidative stress and apoptosis in the mouse liver

Yujiao Lu, Qin Luo, Hengmin Cui, Huidan Deng, Ping Kuang, Huan Liu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao,

https://doi.org/10.18632/aging.101257 pp 1623—1639

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Lu Y, Luo Q, Cui H, Deng H, Kuang P, Liu H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L, . Sodium fluoride causes oxidative stress and apoptosis in the mouse liver. . 9:1623-1639. https://doi.org/10.18632/aging.101257

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                TY  - JOUR
                AU  - Lu, Yujiao 
                AU  - Luo, Qin 
                AU  - Cui, Hengmin 
                AU  - Deng, Huidan 
                AU  - Kuang, Ping 
                AU  - Liu, Huan 
                AU  - Fang, Jing 
                AU  - Zuo, Zhicai 
                AU  - Deng, Junliang 
                AU  - Li, Yinglun 
                AU  - Wang, Xun 
                AU  - Zhao, Ling 
                TI  - Sodium fluoride causes oxidative stress and apoptosis in the mouse liver
                JO  - 
                JA  - 
                VL  - 9
                IS  - 6
                PB  - 
                SN  - 
                UR  - https://doi.org/10.18632/aging.101257
                DO  - 10.18632/aging.101257
                SP  - 1623
                EP  - 1639
                PY  - 
                AB  - The current study was conducted to investigate the effect of sodium fluoride (NaF) on the oxidative stress and apoptosis as well as their relationship in the mouse liver by using methods of flow cytometry, quantitative real-time polymerase chain reaction (qRT-PCR), western blot, biochemistry and experimental pathology. 240 four-week-old ICR mice were randomly divided into 4 groups and exposed to different concentration of NaF (0 mg/kg, 12 mg/kg, 24 mg/kg and 48 mg/kg) for a period of 42 days. The results showed that NaF caused oxidative stress and apoptosis. NaF-caused oxidative stress was accompanied by increasing reactive oxygen species (ROS) and malondialdehyde (MDA) levels, and decreasing mRNA expression levels and activities of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GSH-PX) and glutathione-s-transferase (GST). NaF induced apoptosis via tumor necrosis factor recpter-1 (TNF-R1) signaling pathway, which was characterized by significantly increasing mRNA and protein expression levels of TNF-R1, Fas associated death domain (FADD), TNFR-associated death domain (TRADD), cysteine aspartate specific protease-8 (caspase-8) and cysteine aspartate specific protease-3 (caspase-3) in dose- and time-dependent manner. Oxidative stress is involved in the process of apoptotic occurrence, and can be triggered by promoting ROS production and reducing antioxidant function. NaF-caused oxidative stress and apoptosis finally impaired hepatic function, which was strongly supported by the histopathological lesions and increased serum alanine amino transferase (ALT), aspartic acid transferase (AST), alkaline phosphatase (AKP) activities and TBIL contents.
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Correction: Early age decline in DNA repair capacity in the liver: in depth profile of differential gene expression

Avital Guedj, Anat Geiger-Maor, Hadar Benyamini, Yaval Nevo, Sharona Elgavish, Eithan Galun, Hagai Amsalem, Jacob Rachmilewitz,

https://doi.org/10.18632/aging.101242 pp 1640

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Guedj A, Geiger-Maor A, Benyamini H, Nevo Y, Elgavish S, Galun E, Amsalem H, Rachmilewitz J, . Correction: Early age decline in DNA repair capacity in the liver: in depth profile of differential gene expression. . 9:1640-1640. https://doi.org/10.18632/aging.101242

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Volume 9, Issue 6

About the Cover

Editorials

Synergistic immunotoxin-paclitaxel combination against lymphoma

Fabian Müller,

Tumor suppressors revival in CLL

Giovanna Carrà, Riccardo Taulli, Alessandro Morotti,

BET-inhibitors as sensitizers for BH3-mimetics

Chiaki Tsuge Ishida, Georg Karpel-Massler, Markus D. Siegelin,

Review

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Research Papers

The association between telomere length and mortality in Bangladesh

Melatonin prevents postovulatory oocyte aging and promotes subsequent embryonic development in the pig

Tao Wang, Ying-Ying Gao, Li Chen, Zheng-Wen Nie, Wei Cheng, Xiaoyan Liu, Heide Schatten, Xia Zhang, Yi-Liang Miao,

Identification of an 88-microRNA signature in whole blood for diagnosis of hepatocellular carcinoma and other chronic liver diseases

Xiao-Ran Long, Yao-Jun Zhang, Mei-Yin Zhang, Keng Chen, X.F Steven Zheng, Hui-Yun Wang,

CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630

Yan Zhang, Hao Liu, Wende Li, Jiang Yu, Jin Li, Zhiyong Shen, Gentai Ye, Xiaolong Qi, Guoxin Li,

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Quynh Nhu Dinh, Grant R. Drummond, Barbara K. Kemp-Harper, Henry Diep, T. Michael De Silva, Hyun Ah Kim, Antony Vinh, Avril A.B. Robertson, Matthew A. Cooper, Ashley Mansell, Sophocles Chrissobolis, Christopher G. Sobey,

Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory

Simona Foscarin, Ruma Raha-Chowdhury, James W. Fawcett, Jessica C.F. Kwok,

Sodium fluoride causes oxidative stress and apoptosis in the mouse liver

Yujiao Lu, Qin Luo, Hengmin Cui, Huidan Deng, Ping Kuang, Huan Liu, Jing Fang, Zhicai Zuo, Junliang Deng, Yinglun Li, Xun Wang, Ling Zhao,

Correction

Correction: Early age decline in DNA repair capacity in the liver: in depth profile of differential gene expression

Avital Guedj, Anat Geiger-Maor, Hadar Benyamini, Yaval Nevo, Sharona Elgavish, Eithan Galun, Hagai Amsalem, Jacob Rachmilewitz,

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