Research Paper Volume 10, Issue 5 pp 951—972
Non-senescent Hydra tolerates severe disturbances in the nuclear lamina
- 1 Zoological Institute, Christian-Albrechts University of Kiel, Kiel D-24118, Germany
- 2 Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg D-97074, Germany
Received: February 23, 2018 Accepted: April 28, 2018 Published: May 10, 2018
https://doi.org/10.18632/aging.101440How to Cite
Copyright: Klimovich et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The cnidarian Hydra is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme longevity and non-senescence in long-living animals remains unknown. Here we analyze the role of a single lamin protein in non-senescence of Hydra. We demonstrate that proliferation of stem cells in Hydra is robust against the disturbance of Lamin expression and localization. While Lamin is indispensable for Hydra, the stem cells tolerate overexpression, downregulation and mislocalization of Lamin, and disturbances in the nuclear envelope structure. This extraordinary robustness may underlie the indefinite self-renewal capacity of stem cells and the non-senescence of Hydra. A relatively low complexity of the nuclear envelope architecture in basal Metazoa might allow for their extreme lifespans, while an increasing complexity of the nuclear architecture in bilaterians resulted in restricted lifespans.