Research Paper Volume 10, Issue 12 pp 4166—4174
Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats
- 1 Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan
- 2 Athletic Training and Health Department, National Taiwan Sport University, Taoyuan, Taiwan, Laboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan
- 3 Medical Research Center for Exosome and Mitochondria Related Diseases, China Medical University and Hospital, Taichung, Taiwan
- 4 Department of Nursing, Meiho University, Pingtung, Taiwan
- 5 Department of Healthcare Administration, Asia University, Taichung, Taiwan
- 6 Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- 7 Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan
- 8 Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China
- 9 Department of Biological Science and Technology, China Medical University, Taichung, Taiwan
- 10 Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
- 11 Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan
- 12 Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
Received: August 30, 2018 Accepted: December 6, 2018 Published: December 23, 2018
https://doi.org/10.18632/aging.101714How to Cite
Copyright: Chen et al. This is an open‐access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Exercise is known to be beneficial in controlling aging associated disorders however, the consequence of long-term exercise on cardiac health among aging population is not much clear. In this study the protective effect of exercise on aging associated cardiac disorders was determined using a D-galactose-induced aging model. Eight weeks old Sprague Dawley rats were given intraperitoneal injection of 150 mL/kg D-galactose. Swimming exercise was provided in warm water for 60 min/day for five days per week. Hematoxylin and eosin staining of cardiac tissue sections revealed cardiomyocyte disarrangements in the aging rat hearts but long-term exercise training showed improvements in the cardiac histology. Exercise training also enhanced the expression levels of proteins such as SIRT1, PGC-1α and AMPKα1 that are associated with energy homeostasis and further suppressed aging associated inflammatory cytokines. Our results show that long-term exercise training potentially enhances SIRT1 associated anti-aging signaling and provide cardio-protection against aging.