Research Paper Volume 14, Issue 19 pp 7866—7876
Comprehensive analysis of DTYMK for estimating the immune microenvironment, diagnosis, prognosis effect in patients with lung adenocarcinoma
- 1 Department of Neurosurgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650223, Yunnan Province, China
- 2 Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
- 3 Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650223, Yunnan Province, China
- 4 Department of Respiratory Medicine, The Second Affiliated Hospital of Kunming Medical University, Kunming 650223, Yunnan Province, China
- 5 College of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China
- 6 Department of Oncology, The People’s Hospital of Lishui, Lishui 323000, Zhejiang, China
Received: May 13, 2022 Accepted: September 17, 2022 Published: September 27, 2022
https://doi.org/10.18632/aging.204308How to Cite
Copyright: © 2022 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
The expression of deoxythymidylate kinase (DTYMK) is up-regulated in liver cancer. However, the underlying biological function and potential mechanisms of DTYMK driving the progression of lung adenocarcinoma remains unclear. In this study, we investigated the role of DTYMK in lung adenocarcinoma and found that the expression of DTYMK in LUAD tissues was significantly higher than that of DTYMK expression in adjacent normal tissues. Kaplan-Meier survival analysis showed that patients with higher DTYMK expression correlated with adverse prognosis. ROC curve analysis showed that the AUC value of DTYMK was 0.914. Correlation analysis showed that DTYMK expression was associated with immune infiltration in LUAD. Finally, we determine that DTYMK regulated cell proliferation, cell migration, and cell cycle of lung adenocarcinoma in vitro. In conclusion, our data demonstrated that DTYMK was correlated with progression and immune infiltration, and could serve as a prognostic biomarker for lung adenocarcinoma.