Research Paper Volume 14, Issue 19 pp 8013—8031
Noncoding RNAs-mediated overexpression of KIF14 is associated with tumor immune infiltration and unfavorable prognosis in lung adenocarcinoma
- 1 Department of Oncology, The Third Affiliated Hospital of Hunan University of Chinese Medicine, Zhuzhou, Hunan Province 412000, PR China
- 2 Department of Oncology, The First Affiliated Hospital of Hunan College of Traditional Chinese Medicine, Zhuzhou, Hunan Province 412000, PR China
- 3 Department of Radiology, The Third Affiliated Hospital of Hunan University of Chinese Medicine, Zhuzhou, Hunan Province 412000, PR China
- 4 Department of Radiology, The First Affiliated Hospital of Hunan College of Traditional Chinese Medicine, Zhuzhou, Hunan Province 412000, PR China
Received: June 7, 2022 Accepted: September 23, 2022 Published: October 11, 2022
https://doi.org/10.18632/aging.204332How to Cite
Copyright: © 2022 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Kinesin family member 14 (KIF14) is potentially oncogenic and acts as a chromokinesin via binding to microtubules and chromatin during the bipolar spindle formation. KIF14 overexpression is a significant prognostic biomarker in various cancers. However, the expression, prognosis, mechanism, and tumor immune regulation of KIF14 in lung adenocarcinoma (LUAD) remain obscure. Our results demonstrated that KIF14 was upregulated in a variety of cancers, including LUAD. High-expression of KIF14 in LUAD was associated with pathological tumor stage, N stage and unfavorable prognosis. Both univariate and multivariate Cox regression results demonstrated that KIF14 was a significant independent risk factor influencing the prognosis of LUAD patients. The most promising upstream ncRNA-associated pathway of KIF14 in LUAD was determined to be GSEC/TYMSOS-hsa-miR-101-3p axis according to the starBase and The Cancer Genome Atlas databases. Furthermore, upregulation of KIF14 in LUAD was positively correlated with tumor mutation burden, microsatellite instability, immune checkpoint-related gene expression, immune cell biomarkers, and tumor immune cell infiltration. This study reveals that ncRNAs-mediated overexpression of KIF14 is associated with tumor immune infiltration and unfavorable prognosis in LUAD.
Abbreviations
KIF14: Kinesin family member 14; LUAD: lung adenocarcinoma; ncRNAs: non-coding RNAs; OS: overall survival; PFS: progression-free survival; PAAD: pancreatic adenocarcinoma; lncRNA: long non-coding RNAs; miRNAs: microRNAs; ICI: immune cell infiltration; TCGA: The Cancer Genome Atlas; K-M: Kaplan-Meier; ceRNA: competing endogenous RNA; TMB: tumor mutation burden; MSI: microsatellite instability; UCEC: endometrial carcinoma; THCA: thyroid carcinoma; STAD: stomach adenocarcinoma; SARC: sarcoma; READ: rectum adenoma; PRAD: prostate adenocarcinoma; LUSC: lung squamous cell carcinoma; LIHC: liver hepatocellular carcinoma; KIRP: kidney renal papillary cell carcinoma; KIRC: kidney renal clear cell carcinoma; HNSC: head and neck squamous cell carcinoma; GBM: glioblastoma multiforme; ESCA: esophageal carcinoma; COAD: colon adenocarcinoma; CHOL: cholangiocarcinoma; CESC: endocervical adenocarcinoma; BRCA: breast invasive carcinoma; BLCA: cervical squamous cell carcinoma and bladder urothelial carcinoma; MESO: mesothelioma; ACC: adrenocortical carcinoma; SKCM: skin cutaneous melanoma; TGCT: testicular germ cell tumors; DLBC: diffuse large B-cell lymphoma; CTLA4: cytotoxic T-lymphocyte associated protein 4.