Review Volume 15, Issue 4 pp 905—913
Cellular senescence: when growth stimulation meets cell cycle arrest
- 1 Roswell Park Comprehensive Cancer Center, NY 14263, USA
Received: December 1, 2022 Accepted: February 16, 2023 Published: February 19, 2023
https://doi.org/10.18632/aging.204543How to Cite
Copyright: © 2023 Blagosklonny This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
At the very moment of cell-cycle arrest, the cell is not senescent yet. For several days in cell culture, the arrested cell is acquiring a senescent phenotype. What is happening during this geroconversion? Cellular enlargement (hypertrophy) and hyperfunctions (lysosomal and hyper-secretory) are hallmarks of geroconversion.