Interviews with Outstanding Authors

Novel TRKB Agonists Activate TRKB and Downstream ERK and AKT Signaling

Dr. Ya-Jen Chiu from the Department of Life Science at National Taiwan Normal University in Taipei, discusses a paper she co-authored that was published by Aging (Aging-US) in Volume 14, Issue 18, “Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity.”

DOI - https://doi.org/10.18632/aging.204306

Lotus Germ Extract Rejuvenates Fibroblasts Via Restoration of Disrupted Proteostasis

Dr. Takushi Namba, Associate Professor at Kochi University in Japan, discusses a research paper he co-authored that was published by Aging (Aging-US) in Volume 14, Issue 19, entitled, “Lotus germ extract rejuvenates aging fibroblasts via restoration of disrupted proteostasis by the induction of autophagy.”

DOI - https://doi.org/10.18632/aging.204303

Psychological Factors Contribute to Biological Aging in Chinese Older Adults

Fedor Galkin, Scientific Director at Deep Longevity, Inc. in Hong Kong, discusses a research paper he co-authored that was published by Aging (Aging-US) as the cover for Volume 14, Issue 18, entitled, “Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adults.”

DOI - https://doi.org/10.18632/aging.204264

Longevity & Aging Series Episode 5: Dr. Amit Sharma

Dr. Amit Sharma, Group Lead from SENS Research Foundation, discusses a research paper he co-authored that was published in Volume 14, Issue 5, of Aging (Aging-US), entitled, “Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells.”

DOI - https://doi.org/10.18632/aging.203931

Epigenetic Clocks Association with Perceived Discrimination, Depressive Symptoms

Dr. May Beydoun from the Laboratory of Epidemiology and Population Sciences, NIA/NIH/IRP, in Baltimore, MD, discusses a research paper she co-authored that was published by Aging (Aging-US) as the cover for Volume 14, Issue 13, entitled, “Epigenetic clocks and their association with trajectories in perceived discrimination and depressive symptoms among US middle-aged and older adults.”

DOI - https://doi.org/10.18632/aging.204150

Longevity & Aging Series Episode 4: Drs. Carly Bobak, Cristian Coarfa and Andrew DiNardo

In episode 4 of the Longevity & Aging Series, Drs. Carly Bobak, Cristian Coarfa and Andrew DiNardo discuss a research paper they co-authored that was published in Volume 14, Issue 5, of Aging (Aging-US), entitled, “Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis.”

DOI - https://doi.org/10.18632/aging.203936

Longevity & Aging Series Episode 3: Dr. Steve Horvath - Epigenetic Clocks

In episode 3 of the Longevity & Aging Series, Dr. Steve Horvath, Professor of Human Genetics and Biostatistics at UCLA, and Principal Investigator at Altos Labs, discusses the evolution of aging research and epigenetic clocks with host Dr. Brian Chen.

Special Collection - https://www.aging-us.com/special-collections-archive/steve-horvath

Longevity & Aging Series Episode 2: Dr. Steve Horvath’s Special Collection in Aging

In the second installment of the Longevity & Aging Series, Dr. Steve Horvath revisits papers he co-authored that were published by Aging (Aging-US) and featured as a special collection of his research.

Special Collection - https://www.aging-us.com/special-collections-archive/steve-horvath

Biological Age in Diabetes and Precision Medicine

Dr. Cristina Aguayo-Mazzucato from Beta Cell Aging Lab, Joslin Diabetes Center, Harvard Medical School, discusses an editorial she co-authored that was published by Aging (Aging-US) in Volume 14, Issue 11, entitled, “Biological age in diabetes and precision medicine.”

DOI - https://doi.org/10.18632/aging.204123

Facial Expression Recognition Predicts Neuropsychiatric Symptoms of Dementia

Dr. Liang-Kung Chen from the National Yang-Ming Chiao-Tung University, Taipei, Taiwan details a research paper he co-authored that was published by Aging (Aging-US) in Volume 14, Issue 3, entitled, “Predicting neuropsychiatric symptoms of persons with dementia in a day care center using a facial expression recognition system.”

DOI - https://doi.org/10.18632/aging.203869

Longevity & Aging Series Episode 1: Dr. Alex Zhavoronkov and Dr. Frank Pun

In the first episode of the Longevity & Aging Series, Drs. Alex Zhavoronkov and Frank Pun discuss, in detail, their recently published research paper, “Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine.”

DOI - https://doi.org/10.18632/aging.203960

The puzzling interplay between p53 and Sp1

Dr. Ariella Oppenheim from the Department of Hematology, Hebrew University Faculty of Medicine, Jerusalem, Israel, details an editorial she co-authored that was published by Aging (Aging-US) in Volume 9, Issue 5, entitled, “The puzzling interplay between p53 and Sp1.”

DOI - https://doi.org/10.18632/aging.101238 (PDF download)

Full text - https://www.aging-us.com/article/101238

DNA Methylation-based Measures of Biological Age

Aging-US published "DNA methylation-based measures of biological age: meta-analysis predicting time to death" in 2016, which reported that estimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust biomarkers of age in humans.

DOI - https://doi.org/10.18632/aging.101020

Epigenetic Age of the Pre-frontal Cortex

Aging-US published "Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning" in 2015, which reported that there is an urgent need to develop molecular biomarkers of brain age in order to advance our understanding of age related neurodegeneration.

DOI - https://doi.org/10.18632/aging.100864

Iron: An Underrated Factor in Aging

Dennis Mangan from MTOR LLC in Bakersfield, California details his theory article published by Aging (Aging-US), entitled, “Iron: an underrated factor in aging.”

DOI - https://doi.org/10.18632/aging.203612

Interview with Dr. Junhua Li

Interview with Dr. Junhua Li from the University of Essex talking about his paper "Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation"

DOI - https://doi.org/10.18632/aging.102023

Dr. Velia M. Fowler and Dr. Catherine Cheng

Interview with Dr. Velia M. Fowler and Dr. Catherine Cheng from the Department of Molecular Medicine, The Scripps Research Institute about their paper " Age-related changes in eye lens biomechanics, morphology, refractive index and transparency"

DOI - https://doi.org/10.18632/aging.102584

Interview with Dr. Blanca Molins

Interview with Dr. Blanca Molins from the Group of Ocular Inflammation talking about her paper "Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier in vitro: implications for age-related macular degeneration"

DOI - https://doi.org/10.18632/aging.103655

Interview with Dr. Lei Feng

Interview with Dr. Lei Feng from the Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore about his paper " Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation"

DOI - https://doi.org/10.18632/aging.102023

Interview with Dr. Alejandro Martin-Montalvo and Dr. Benoit Raymond Gauthier

Interview with Dr. Alejandro Martin-Montalvo and Dr. Benoit Raymond Gauthier from the Department of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER about their paper " Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging"

DOI - https://doi.org/10.18632/aging.102285

Interview with Dr. Julija Jurić

Interview with Dr. Julija Jurić from the Genos Glycoscience Research Laboratory talking about her paper "Effects of estradiol on biological age measured using the glycan age index"

DOI - https://doi.org/10.18632/aging.104060

Interview with Dr. Dale E. Bredesen

Interview with Dr. Dale E. Bredesen from UCLA & The Buck Institute for Research on Aging talking about his paper "Alzheimer’s disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics"

DOI - https://doi.org/10.18632/aging.103883

Interview with Dr. Kara Fitzgerald

Interview with Dr. Kara Fitzgerald from The Institute for Functional Medicine talking about her paper "Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial"

DOI - https://doi.org/10.18632/aging.202913

Interview with Dr. David A. Sinclair

Interview with Dr. David A. Sinclair from Glenn Laboratories for Aging Research at Harvard Medical School talking about his paper "Why does COVID-19 disproportionately affect older people?"

DOI - https://doi.org/10.18632/aging.103344

Interview with Dr. Alex Zhavoronkov

Interview with Dr. Alex Zhavoronkov from Insilico Medicine & The Biogerontology Research Foundation talking about their paper "Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections"

DOI - https://doi.org/10.18632/aging.102988

Interview with Andrei Gudkov

Interview with Andrei Gudkov of the Roswell Park Cancer Institute in Buffalo, NY talking about their paper "p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli"

DOI - https://doi.org/10.18632/aging.101268

Interview with Dr. Gil Atzmon

Interview with Dr. Gil Atzmon from the Department of Medicine and Genetics at Albert Einstein College of Medicine, in the Bronx, NY 10461, USA as well as the Department of Human Biology, Faculty of Natural Science, at the University of Haifa, in Haifa, Israel talking about their featured cover paper for Volume 9 Issue 1"The complex genetics of gait speed: genome-wide meta-analysis approach"

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Interview with Dr. Brian Kennedy & Dr. Linda Partridge

Left - Dr. Brian Kennedy from the Buck Institute for Research on Aging, Novato, CA, USA and the Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore.

Right - Dame Linda Partridge DBE FMedSci, currently the Weldon Professor of Biometry at the Department of Genetics, Evolution and Environment of University College London, director of UCL's Institute of Healthy Aging and founding director of the Max Planck Institute for the Biology of Aging.

In this interview they are talking about their meeting report on the 2nd interventions in aging conference published in Volume 9 Issue 4 of Aging.

Full Text

Article Report

Interview with Dr. Marina P. Antoch

Interview with Dr. Marina P. Antoch from the Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA speaking about their Featured Cover Paper in Volume 9 Issue 3 of Aging "Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice"

Interview with Dr. Ganesh V. Halade

Interview with Dr. Ganesh V. Halade from the Division of Cardiovascular Disease Department of Medicine, The University of Alabama at Birmingham, AL 35233, USA talking about their paper in Aging, Albany NY Volume 8 issue 11 "Aging dysregulates D- and E-series resolvins to modulate cardiosplenic and cardiorenal network following myocardial infarction"

Interview with Dr. Robert J. Shmookler Reis and Dr. Srinivas Ayyadevara

Video interview with Dr. Robert J. Shmookler Reis and Dr. Srinivas Ayyadevara from the Reynolds Institute on Aging, Dept. of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR talking about their featured cover paper in Aging Volume 8 Issue 12 "Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans"

Interview with Dr. Dale Bredesen

Video interview with Dr. Dale Bredesen of Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA and the Buck Institute for Research on Aging, Novato, CA talking about their featured cover paper in Aging Volume 6 Issue 9 - "Reversal of cognitive decline: A novel therapeutic program"

Interview with Dr. Steve Horvath

Interview with Dr. Steve Horvath - Department of Human Genetics and Biostatistics University of California, Los Angeles David Geffen School of Medicine 695 Charles E. Young Drive South Los Angeles, CA 90095-7088, USA talking about their featured cover paper in Aging Volume 8 Issue 9 - "DNA methylation-based measures of biological age: meta-analysis predicting time to death"

Interview with Dr. Leo Tsuda

Interview with Dr. Leo Tsuda from the Center for Development

of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu, Aichi, Japan talking about their paper published in Aging Volume 8 Issue 3 "Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in high-frequency sound perception".

Interview with Dr. Andrei Gudkov

Video interview with Dr. Andrei Gudkov, an Editor-in-chief of Oncotarget, and Senior Vice President for Basic Science at Roswell Park Cancer Institute in Buffalo, NY sharing findings from, “Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells” , a study that may play a role in delaying age-related diseases. Dr. Gudkov's study has identified macrophage cells as being an associated with cellular senescence. This subtype may hold potential for anti-aging treatment. Courtesy of Roswell Park Cancer Institute .

Interview with Dr. Vera Gorbunova

Video interview with Dr. Vera Gorbunova, Doris Johns Cherry Professor; Professor of Biology; Associate Professor of Oncology, Department of Biology, University of Rochester, Rochester, NY - talking about their cover paper in Aging - Volume 8 Issue 5 - "Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan"

Interview with Dr. Patricia Rousselle

Video interview with Dr. Patricia Rousselle, Head of the Cell / Microenvironment Cross-Talk and Tissue Repair Laboratory in the Biologie Tissulaire et Ingénierie Thérapeutique Department in France - talking about their cover paper in Aging - Volume 8 Issue 4 - "Perlecan expression influences the keratin 15‐positive cell population fate in the epidermis of aging skin"