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• Research Paper Volume 13, Issue 6 pp 8095-8114

  Expression and prognostic value of transcription-associated cyclin-dependent kinases in human breast cancer

  Relevance score: 7.7270274

  Ning Li, Shaoquan Zheng, Zhicheng Xue, Zhenchong Xiong, Yutian Zou, Yuhui Tang, Wei-Dong Wei, Lu Yang

  Keywords: CDK, breast cancer, transcription, bioinformatics analysis, biomarker

  Published in Aging on March 3, 2021

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  The expression and prognostic significance of transcription-associated cyclin-dependent kinases (TA-CDKs) in breast cancer have not been systematically investigated. Using Oncomine, GEPIA2, the Human Protein Atlas, the Kaplan-Meier Plotter, cBioPortal, Metascape, and DAVID 6.8, we profiled the expression of TA-CDKs in breast cancer, inferred their biological functions, and assessed their effect on prognosis. The expression of CDK7/10/13/19 mRNAs in breast cancer tissues was significantly higher than in normal breast tissues. Survival analysis of breast cancer patients revealed that increased CDK8 expression was associated with inferior overall survival (OS), higher expression of CDK7 or CDK8 was associated with inferior relapse-free survival (RFS), but higher expression of CDK13 was associated with favorable RFS and OS. In addition, a high genetic alteration rate (56%) in TA-CDKs was associated with shorter OS. On functional enrichment analysis, top GO enrichment items for TA-CDKs and their neighboring genes included cyclin-dependent protein serine/threonine kinase activity and transferase complex. The top KEGG pathways included cell cycle and mismatch repair. These results suggest that CDK7/8/13 are potential prognostic biomarkers for breast cancer patients and provide novel insight for future studies examining their usefulness as therapeutic targets.

• Editorial Volume 8, Issue 3 pp 425-426

  Stopping cells from dividing

  Relevance score: 5.691935

  Kurt Engeland

  Keywords: cell cycle arrest, p53, DREAM, E2F, CHR site, transcription, pRB, p130, p21 CDK inhibitor

  Published in Aging on March 29, 2016