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• Research Paper Volume 12, Issue 11 pp 10211-10222

  Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency

  Relevance score: 6.643429

  Yigit Cakiroglu, Ayse Saltik, Aysen Yuceturk, Ozge Karaosmanoglu, Sule Yildirim Kopuk, Richard T. Scott, Bulent Tiras, Emre Seli

  Keywords: primary ovarian insufficiency, platelet rich plasma, PRP, in vitro fertilization

  Published in Aging on June 5, 2020

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  We aimed to determine whether intraovarian injection of autologous platelet rich plasma (PRP) improves response to ovarian stimulation and in vitro fertilization (IVF) outcome in women with primary ovarian insufficiency (POI). Women (N=311; age 24-40) diagnosed with POI based on ESHRE criteria underwent intraovarian PRP injection. Markers of ovarian reserve, and IVF outcome parameters were followed. PRP treatment resulted in increased antral follicle count (AFC) and serum antimullerian hormone (AMH), while serum follicle stimulating hormone (FSH) did not change significantly. After PRP injection, 23 women (7.4%) conceived spontaneously, 201 (64.8%) developed antral follicle(s) and attempted IVF, and 87 (27.8%) had no antral follicles and therefore did not receive additional treatment. Among the 201 women who attempted IVF, 82 (26.4% of total) developed embryos; 25 of these women preferred to cryopreserve embryos for transfer at a later stage, while 57 underwent embryo transfer resulting in 13 pregnancies (22.8% per transfer, 4% of total). In total, of the 311 women treated with PRP, 25 (8.0%) achieved livebirth/sustained implantation (spontaneously or after IVF), while another 25 (8.0%) cryopreserved embryos. Our findings suggest that in women with POI, intraovarian injection of autologous PRP might be considered as an alternative experimental treatment option.

  

  Flow-chart of the clinical outcomes in women with POI who underwent PRP injection. SI: sustained implantation.

  
  
  

  

  Antral follicle count, AMH and FSH levels before and after PRP injection. The ends of the boxes are the upper and lower quartiles, so the box spans the interquartile range (25^th to 75^th percentile). The horizontal line inside the boxplot represents the median value. The whiskers extend between 5%-95%. *: P<0.05