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• Research Paper Volume 13, Issue 11 pp 14910-14923

  Adipose matrix complex: a high-rigidity collagen-rich adipose-derived material for fat grafting

  Relevance score: 12.107576

  Ye Li, Pan Zhang, Xue Zhang, Xin Bi, Mengfan Wu, Jialiang Zou, Zijue Wang, Feng Lu, Ziqing Dong, Jianhua Gao

  Keywords: fat grafting, stiffness, collagen, rigid supportive filling, mechanical process

  Published in Aging on June 9, 2021

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  Due to the low percentage of collagen, the rigid support capacity of fat grafts remains unsatisfactory for some clinical applications. In this study, we evaluated a strategy in which adipose matrix complex (AMC) was collected via a mechanical process and transplanted for supportive filling of the face. Our AMC samples were collected from adipose tissue by a filter device consisting of a sleeve, three internal sieves, and a filter bag (100 mesh). AMC derived from adipose tissue had fewer cells than Coleman fat, but much higher levels of collagen and stiffness. Retention rates 90 days after transplantation in nude mice were higher for AMC than for Coleman fat (75±7.5% vs. 42±13.5%; P < 0.05). In addition, AMC maintained a higher stiffness (~6 kPa vs. ~2 kPa; P < 0.01) and stably retained a higher level of collagen. Our findings demonstrate that mechanical collection of AMC from adipose tissue is a practical method for improving fat graft retention and rigid support. This strategy has the potential to improve the quality of lipoaspirates for patients requiring rigid supportive filling.