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• Research Paper Volume 12, Issue 7 pp 6037-6048

  Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients

  Relevance score: 18.394966

  Zongguo Yang, Jia Shi, Zhang He, Ying Lü, Qingnian Xu, Chen Ye, Shishi Chen, Bozong Tang, Keshan Yin, Yunfei Lu, Xiaorong Chen

  Keywords: coronavirus disease 2019, COVID-19, monocyte-lymphocyte ratio, MLR, age

  Published in Aging on April 10, 2020

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  Objective: This study aimed to investigate the potential parameters associated with imaging progression on chest CT from coronavirus disease 19 (COVID-19) patients.

  Results: The average age of 273 COVID-19 patients enrolled with imaging progression were older than those without imaging progression (p = 0.006). The white blood cells, platelets, neutrophils and acid glycoprotein were all decreased in imaging progression patients (all p < 0.05), and monocytes were increased (p = 0.025). The parameters including homocysteine, urea, creatinine and serum cystatin C were significantly higher in imaging progression patients (all p < 0.05), while eGFR decreased (p < 0.001). Monocyte-lymphocyte ratio (MLR) was significantly higher in imaging progression patients compared to that in imaging progression-free ones (p < 0.001). Logistic models revealed that age, MLR, homocysteine and period from onset to admission were factors for predicting imaging progression on chest CT at first week from COVID-19 patients (all p < 0.05).

  Conclusion: Age, MLR, homocysteine and period from onset to admission could predict imaging progression on chest CT from COVID-19 patients.

  Methods: The primary outcome was imaging progression on chest CT. Baseline parameters were collected at the first day of admission. Imaging manifestations on chest CT were followed-up at (6±1) days.

  

  Examples of imaging progression (A) and progression-free (B) in chest CT from COVID-19 patients.

  
  
  

  

  ALRI (A), APRI (B), MLR (C), NLR (D), PLR (E) and SII (F) model comparisons between imaging progression and progression-free COVID-19 patients.

  
  
  

  

  ROC of MLR (A), age (B), homocysteine (C) and ROC comparison (D) for imaging progression in chest CT from COVID-19 patients.