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Research Paper Volume 13, Issue 15 pp 19486-19509
A combined hypoxia and immune gene signature for predicting survival and risk stratification in triple-negative breast cancer
Relevance score: 8.81082Xia Yang, Xin Weng, Yajie Yang, Meng Zhang, Yingjie Xiu, Wenfeng Peng, Xuhui Liao, Meiquan Xu, Yanhua Sun, Xia Liu
Keywords: triple-negative breast cancer, risk stratification, hypoxia, immune, survival
Published in Aging on August 2, 2021
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Research Paper Volume 12, Issue 21 pp 21355-21375
Association of folate intake and plasma folate level with the risk of breast cancer: a dose-response meta-analysis of observational studies
Relevance score: 9.227431Xueting Ren, Peng Xu, Dai Zhang, Kang Liu, Dingli Song, Yi Zheng, Si Yang, Na Li, Qian Hao, Ying Wu, Zhen Zhai, Huafeng Kang, Zhijun Dai
Keywords: breast cancer, risk, folate, dose-response, meta-analysis
Published in Aging on November 4, 2020
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Research Paper Volume 12, Issue 18 pp 18415-18435
Association of vitamin C intake with breast cancer risk and mortality: a meta-analysis of observational studies
Relevance score: 9.227431Dai Zhang, Peng Xu, Yiche Li, Bajin Wei, Si Yang, Yi Zheng, Lijuan Lyu, Yujiao Deng, Zhen Zhai, Na Li, Nan Wang, Jun Lyu, Zhijun Dai
Keywords: vitamin C, breast cancer risk, survival, meta-analysis
Published in Aging on September 29, 2020
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Research Paper Volume 12, Issue 7 pp 5894-5906
Risk of breast cancer-related death in women with a prior cancer
Relevance score: 9.129781Fei Ji, Ci-Qiu Yang, Xiao-Ling Li, Liu-Lu Zhang, Mei Yang, Jie-Qing Li, Hong-Fei Gao, Teng Zhu, Min-Yi Cheng, Wei-Ping Li, Si-Yan Wu, Ai-Ling Zhong, Kun Wang
Keywords: second primary malignancy, breast cancer, risk factor, survival
Published in Aging on April 6, 2020
Overall survival (OS) of patients with breast cancer as a second primary cancer. (A) OS curves of patients with different types of prior cancer. (B) the percentage of deaths related to breast cancer or prior cancer among patients with different types of prior cancer. For some types of prior cancer, breast cancer resulted in more deaths than the prior cancer.
The association of breast cancer treatment with breast cancer deaths in patients with breast cancer as a second primary cancer. Breast cancer treatment was associated with decreased breast cancer deaths in these patients.
Ratio of breast cancer deaths to prior cancer deaths among patients with different types of prior cancer. Patients with prior gastrointestinal cancer, melanoma, and urinary tract cancer were more likely to die of breast cancer when they had high-grade or stage cT3–T4/N0/M0 breast cancer, but were more likely to die of prior cancer when they had low-grade and stage cT1–2/N0/M0 breast cancer.
Kaplan-Meier survival curves of patients with breast cancer as the second primary cancer or the prior cancer. (A) BCSS was significantly shorter in patients with breast cancer as the second primary cancer than in those with breast cancer as the prior cancer in the entire cohort. (B) OS was significantly shorter in patients with breast cancer as the second primary cancer than in those with breast cancer as the prior cancer in the entire cohort. After PSM, both BCSS (C) and OS (D) were significantly lower in patients with breast cancer as the second primary cancer than in those with breast cancer as the prior cancer.
Kaplan-Meier survival curves of patients with breast cancer as the second primary cancer or the prior cancer and with different hormone receptor statuses. Breast cancer as the second primary cancer was significantly associated with shorter BCSS and OS in hormone receptor-positive subgroups (A–H).
Forest plot of the hazard ratios for survival of patients with breast cancer as the second primary cancer or the prior cancer. Breast cancer as the second primary cancer was associated with short BCSS (A) and OS (B) in most of the subgroups.
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Research Paper Volume 11, Issue 24 pp 12708-12732
Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
Relevance score: 8.352674Dingli Song, Yujiao Deng, Kang Liu, Linghui Zhou, Na Li, Yi Zheng, Qian Hao, Si Yang, Ying Wu, Zhen Zhai, Hongtao Li, Zhijun Dai
Keywords: vitamin D, dose-response, breast cancer risk, menopause, meta-analysis
Published in Aging on December 28, 2019
Flowchart of included studies for the meta-analysis.
Forest plot of meta-analysis of the association between vitamin D intake increment (per 400IU/d) and breast cancer risk. Abbreviations: OR, odds ratio; CI, confidence interval.
Forest plot of meta-analysis of the association between blood vitamin D increment (per 5nmol/L) and breast cancer risk. Abbreviations: OR, odds ratio; CI, confidence interval.
Dose–response meta-analysis of blood vitamin D and breast cancer risk (linear and nonlinear models).
Dose-response meta-analysis of blood vitamin D and breast cancer risk stratified by menopausal status (linear and nonlinear models). Note: (A) Premenopause; (B) Postmenopause.
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Research Perspective Volume 11, Issue 4 pp 1305-1316
Towards a more precise and individualized assessment of breast cancer risk
Relevance score: 9.122292Marie E. Wood, Nicholas H. Farina, Thomas P. Ahern, Melissa E. Cuke, Janet L. Stein, Gary S. Stein, Jane B. Lian
Keywords: breast cancer risk, precision risk assessment, biomarkers, circulating miRNA
Published in Aging on February 20, 2019
Development of a predictive miRNA signature for breast cancer risk among high-risk women. The predictive ability of A) the 6-miRNA risk signature and B) each individual C-miRNA was assessed by ROC curve and AUC based on calculated risk score. The combined expression of the 6 C-miRNAs discriminate cases from controls with increased accuracy and precision than any single miRNA. 95% confidence intervals (CI) are indicated by gray area around each curve. Modified from our 2017 Oncotarget publication [104].