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Online ISSN: 1945-4589
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Special Collection on Cell Senescence and Rapamycin


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Gerosuppression by pan-mTOR inhibitors

Olga V. Leontieva, Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.101155 pp 3535—3551
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Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assay

Ivana Matic, Ajinkya Revandkar, Jingjing Chen, Angela Bisio, Stefano Dall’Acqua, Veronica Cocetta, Paola Brun, Giorgio Mancino, Martina Milanese, Maurizio Mattei, Monica Montopoli, Andrea Alimonti,
https://doi.org/10.18632/aging.101076 pp 3223—3240
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Rapamycin reverses the senescent phenotype and improves immuno-regulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus erythematosus patients through inhibition of the mTOR signaling pathway

Zhifeng Gu, Wei Tan, Juan Ji, Guijian Feng, Yan Meng, Zhanyun Da, Genkai Guo, Yunfei Xia, Xinhang Zhu, Guixiu Shi, Chun Cheng,
https://doi.org/10.18632/aging.100925 pp 1102—1114
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Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

Hannah E. Walters, Sylwia Deneka-Hannemann, Lynne S. Cox,
https://doi.org/10.18632/aging.100872 pp 231—244
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A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition

Clemens Stockklausner, Simon Raffel, Julia Klermund, Obul Reddy Bandapalli, Fabian Beier, Tim H. Brümmendorf, Friederike Bürger, Sven W. Sauer, Georg F. Hoffmann, Holger Lorenz, Laura Tagliaferri, Daniel Nowak, Wolf-Karsten Hofmann, Rebecca Buergermeister, Carolin Kerber, Tobias Rausch, Jan O. Korbel, Brian Luke, Andreas Trumpp, Andreas E. Kulozik,
https://doi.org/10.18632/aging.100835 pp 911—927
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Gerosuppression in confluent cells

Olga V. Leontieva, Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.100714 pp 1010—1018
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Berberine suppresses gero-conversion from cell cycle arrest to senescence

Hong Zhao, H Dorota Halicka, Jiangwei Li, Zbigniew Darzynkiewicz,
https://doi.org/10.18632/aging.100593 pp 623—636
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mTOR pathway and Ca2+ stores mobilization in aged smooth muscle cells

Francisco E. Martín-Cano, Cristina Camello-Almaraz, David Hernandez, Maria J. Pozo, Pedro J. Camello,
https://doi.org/10.18632/aging.100555 pp 339—346
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Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

H. Dorota Halicka, Hong Zhao, Jiangwei Li, Yong-Syu Lee, Tze-Chen Hsieh, Joseph M. Wu, Zbigniew Darzynkiewicz,
https://doi.org/10.18632/aging.100521 pp 952—965
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Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.100475 pp 450—455
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Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.100443 pp 159—165
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Mitochondrial dysfunction and cell senescence — skin deep into mammalian aging

Joao F. Passos, Thomas von Zglinicki,
https://doi.org/10.18632/aging.100432 pp 74—75
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Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression

Olga V. Leontieva, Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.100402 pp 1078—1091
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Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

H. Dorota Halicka, Hong Zhao, Jiangwei Li, Frank Traganos, Sufang Zhang, Marietta Lee, Zbigniew Darzynkiewicz,
https://doi.org/10.18632/aging.100397 pp 1028—1038
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Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?

Vjekoslav Dulic,
https://doi.org/10.18632/aging.100257 pp 3—4
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DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

Olga V. Leontieva, Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.100265 pp 924—935
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Adult-onset, short-term dietary restriction reduces cell senescence in mice

Chunfang Wang, Mandy Maddick, Satomi Miwa, Diana Jurk, Rafal Czapiewski, Gabriele Saretzki, Sabine A.S. Langie, Roger W.L. Godschalk, Kerry Cameron, Thomas von Zglinicki,
https://doi.org/10.18632/aging.100196 pp 555—566
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TP53 and MTOR crosstalk to regulate cellular senescence

Lorenzo Galluzzi, Oliver Kepp, Guido Kroemer,
https://doi.org/10.18632/aging.100202 pp 535—537
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The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

Lioubov G. Korotchkina, Olga V. Leontieva, Elena I. Bukreeva, Zoya N. Demidenko, Andrei V. Gudkov, Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.100160 pp 344—352
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Another "Janus paradox" of p53: induction of cell senescence versus quiescence

Zbigniew Darzynkiewicz,
https://doi.org/10.18632/aging.100165 pp 329—330
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mTOR favors senescence over quiescence in p53-arrested cells

Thaddeus T. Schug,
https://doi.org/10.18632/aging.100164 pp 327—328
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Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential

Zoya N. Demidenko, Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.100115 pp 1008—1016
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