Research Paper Volume 3, Issue 12 pp 1206—1212
Relationship of spindle assembly checkpoint fidelity to species body mass, lifespan, and developmental rate
- 1 University of Bologna; Department of Biochemistry “G. Moruzzi”; Bologna, Italy
- 2 Drexel University College of Medicine; Department of Pathology and Laboratory Medicine; Philadelphia, PA 19129, USA
- 3 Current address; Fox Chase Cancer Center; Department of Cancer Biology; Philadelphia, PA 19046, USA
- 4 Lankenau Institute for Medical Research; Wynnewood, PA 19096, USA
Received: December 23, 2011 Accepted: December 26, 2011 Published: December 26, 2011
https://doi.org/10.18632/aging.100416How to Cite
Abstract
We have examined the tolerance of the spindle assembly checkpoint (SAC), as measured by the appearance of tetraploid cells in the presence of a microtubule inhibitor, in a series of primary cell strains derived from species with diverse lifespan and body size. We find that the integrity of the SAC varies among these species. There is a robust correlation between the integrity of the SAC and body size, but poor correlation with longevity and parameters of species development (i.e., time of female fertility, gestation length, and postnatal growth rate). The results suggest that fidelity of the SAC co-evolved more closely with the number of mitoses needed to reach adulthood than with species lifespan.