Research Paper Volume 15, Issue 7 pp 2460—2472
Relationship between advanced maternal age and decline of endometrial receptivity: a systematic review and meta-analysis
- 1 Reproductive Medicine Center, Xiangya Hospital of Central South University, Changsha, Hunan, China
- 2 Clinical Research Center for Women’s Reproductive Health in Hunan Province, Changsha, Hunan, China
- 3 Reproductive Medicine Center, The Third Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China
- 4 Reproductive Medicine Center, Chengdu Xinan Gynecology Hospital, Chengdu, Sichuan, China
Received: December 11, 2022 Accepted: February 8, 2023 Published: February 27, 2023
https://doi.org/10.18632/aging.204555How to Cite
Copyright: © 2023 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Female fertility decreases with age. A decline in oocyte quality plays a key role in reproductive problems in older women. Whether advanced maternal age (AMA) is associated with a decline in endometrial receptivity (ER) remains controversial. A systematic review and meta-analysis were conducted to evaluate the relationship between AMA and ER. Eighteen eligible studies were included in this meta-analysis. Of the 18 studies, 17, 8, 14, and 9 studies reported the impact of AMA on clinical pregnancy rate (CPR), implantation rate (IR), miscarriage rate (MR), and live birth rate (LBR), respectively. The combined results showed a trend (without significance) toward lower CPR in women with AMA than in younger women. A similar trend of worse outcomes in terms of IR was observed in women with AMA. A significantly higher MR and lower LBR were observed in infertile women with AMA than in younger women. In conclusion, there was a slightly lower IR and CPR without significance; however, significantly increased MR and decreased LBR were observed in women with AMA than in younger women, indicating that AMA is related to the decline of ER. Further prospective cohort studies with a preimplantation genetic testing for aneuploidy model are needed to observe the relationship between AMA and ER and explore the possible mechanisms.