Volume 4, Issue 5

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Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown‐Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, et al, . The second international conference "genetics of aging and longevity". . 4:305-317. https://doi.org/10.18632/aging.100458

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Provider: TY - JOUR AU - Anisimov, Vladimir N. AU - Bartke, Andrzej AU - Barzilai, Nir AU - Batin, Mikhail A. AU - Blagosklonny, Mikhail V. AU - Brown‐Borg, Holly AU - Budovskaya, Yelena AU - Campisi, Judith AU - Friguet, Bertrand AU - Fraifeld, Vadim AU - Franceschi, Claudio AU - Gems, David AU - Gladyshev, Vadim AU - Gorbunova, Vera AU - Gudkov, Andrei V. AU - Kennedy, Brian AU - Konovalenko, Maria AU - Kraemer, Brian AU - Moskalev, Alexey AU - Petropoulos, Isabelle AU - Pasyukova, Elena AU - Rattan, Suresh AU - Rogina, Blanka AU - Seluanov, Andrei AU - Shaposhnikov, Mikhail AU - Reis, Robert Shmookler AU - Tavernarakis, Nektarios AU - Vijg, Jan AU - Yashin, Anatoli AU - Zimniak, Piotr TI - The second international conference "genetics of aging and longevity" JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100458 DO - 10.18632/aging.100458 SP - 305 EP - 317 PY - ER -

Provider: TY - JOUR AU - Anisimov, Vladimir N. AU - Bartke, Andrzej AU - Barzilai, Nir AU - Batin, Mikhail A. AU - Blagosklonny, Mikhail V. AU - Brown‐Borg, Holly AU - Budovskaya, Yelena AU - Campisi, Judith AU - Friguet, Bertrand AU - Fraifeld, Vadim AU - Franceschi, Claudio AU - Gems, David AU - Gladyshev, Vadim AU - Gorbunova, Vera AU - Gudkov, Andrei V. AU - Kennedy, Brian AU - Konovalenko, Maria AU - Kraemer, Brian AU - Moskalev, Alexey AU - Petropoulos, Isabelle AU - Pasyukova, Elena AU - Rattan, Suresh AU - Rogina, Blanka AU - Seluanov, Andrei AU - Shaposhnikov, Mikhail AU - Reis, Robert Shmookler AU - Tavernarakis, Nektarios AU - Vijg, Jan AU - Yashin, Anatoli AU - Zimniak, Piotr TI - The second international conference "genetics of aging and longevity" JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100458 DO - 10.18632/aging.100458 SP - 305 EP - 317 PY - AB - ER -

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Flurkey K, Yuan R, . How the evolutionary theory of aging can guide us in the search for aging genes. . 4:318-319. https://doi.org/10.18632/aging.100460

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Provider: TY - JOUR AU - Flurkey, Kevin AU - Yuan, Rong TI - How the evolutionary theory of aging can guide us in the search for aging genes JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100460 DO - 10.18632/aging.100460 SP - 318 EP - 319 PY - ER -

Provider: TY - JOUR AU - Flurkey, Kevin AU - Yuan, Rong TI - How the evolutionary theory of aging can guide us in the search for aging genes JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100460 DO - 10.18632/aging.100460 SP - 318 EP - 319 PY - AB - ER -

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Berstein LM, . Metformin in obesity, cancer and aging: addressing controversies. . 4:320-329. https://doi.org/10.18632/aging.100455

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Provider: TY - JOUR AU - Berstein, Lev M. TI - Metformin in obesity, cancer and aging: addressing controversies JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100455 DO - 10.18632/aging.100455 SP - 320 EP - 329 PY - ER -

Provider: TY - JOUR AU - Berstein, Lev M. TI - Metformin in obesity, cancer and aging: addressing controversies JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100455 DO - 10.18632/aging.100455 SP - 320 EP - 329 PY - AB - Metformin, an oral anti-diabetic drug, is being considered increasingly for treatment and prevention of cancer, obesity as well as for the extension of healthy lifespan. Gradually accumulating discrepancies about its effect on cancer and obesity can be explained by the shortage of randomized clinical trials, differences between control groups (reference points), gender- and age-associated effects and pharmacogenetic factors. Studies of the potential antiaging effects of antidiabetic biguanides, such as metformin, are still experimental for obvious reasons and their results are currently ambiguous. Here we discuss whether the discrepancies in different studies are merely methodological or inherently related to individual differences in responsiveness to the drug. ER -

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Favaloro B, Allocati N, Graziano V, Di Ilio C, De Laurenzi V, . Role of Apoptosis in disease. . 4:330-349. https://doi.org/10.18632/aging.100459

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Provider: TY - JOUR AU - Favaloro, B. AU - Allocati, N. AU - Graziano, V. AU - Di Ilio, C. AU - De Laurenzi, V. TI - Role of Apoptosis in disease JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100459 DO - 10.18632/aging.100459 SP - 330 EP - 349 PY - ER -

Provider: TY - JOUR AU - Favaloro, B. AU - Allocati, N. AU - Graziano, V. AU - Di Ilio, C. AU - De Laurenzi, V. TI - Role of Apoptosis in disease JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100459 DO - 10.18632/aging.100459 SP - 330 EP - 349 PY - AB - Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling as well and shown that alterations of these pathways lead to human diseases. Indeed both reduced and increased apoptosis can result in pathology. More recently these findings have led to the development of therapeutic approaches based on regulation of apoptosis, some of which are in clinical trials or have entered medical practice. ER -

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Blagosklonny MV, . Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to. . 4:350-358. https://doi.org/10.18632/aging.100461

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Provider: TY - JOUR AU - Blagosklonny, Mikhail V. TI - Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100461 DO - 10.18632/aging.100461 SP - 350 EP - 358 PY - ER -

Provider: TY - JOUR AU - Blagosklonny, Mikhail V. TI - Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100461 DO - 10.18632/aging.100461 SP - 350 EP - 358 PY - AB - Calorie restriction (CR), which deactivates the nutrient-sensing mTOR pathway, slows down aging and prevents age-related diseases such as type II diabetes. Compared with CR, rapamycin more efficiently inhibits mTOR. Noteworthy, severe CR and starvation cause a reversible condition known as “starvation diabetes.” As was already discussed, chronic administration of rapamycin can cause a similar condition in some animal models. A recent paper published in Science reported that chronic treatment with rapamycin causes a diabetes-like condition in mice by indirectly inhibiting mTOR complex 2. Here I introduce the notion of benevolent diabetes and discuss whether starvation-like effects of chronic high dose treatment with rapamycin are an obstacle for its use as an anti-aging drug. ER -

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Kato K, Zweig R, Barzilai N, Atzmon G, . Positive attitude towards life and emotional expression as personality phenotypes for centenarians. . 4:359-367. https://doi.org/10.18632/aging.100456

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Provider: TY - JOUR AU - Kato, Kaori AU - Zweig, Richard AU - Barzilai, Nir AU - Atzmon, Gil TI - Positive attitude towards life and emotional expression as personality phenotypes for centenarians JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100456 DO - 10.18632/aging.100456 SP - 359 EP - 367 PY - ER -

Provider: TY - JOUR AU - Kato, Kaori AU - Zweig, Richard AU - Barzilai, Nir AU - Atzmon, Gil TI - Positive attitude towards life and emotional expression as personality phenotypes for centenarians JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100456 DO - 10.18632/aging.100456 SP - 359 EP - 367 PY - AB - Centenarians have been reported to share particular personality traits including low neuroticism and high extraversion and conscientiousness. Since these traits have moderate to high heritability and are associated with various health outcomes, personality appears linked to bio-genetic mechanisms which may contribute to exceptional longevity. Therefore, the present study sought to detect genetically-based personality phenotypes in a genetically homogeneous sample of centenarians through developing and examining psychometric properties of a brief measure of the personality of centenarians, the Personality Outlook Profile Scale (POPS). The results generated two personality characteristics/domains, Positive Attitude Towards Life (PATL: optimism, easygoing, laughter, and introversion/outgoing) and Emotional Expression (EE: expressing emotions openly and not bottling up emotions). These domains demonstrated acceptable concurrent validity with two established personality measures, the NEO-Five Factor Inventory and Life Orientation Test-Revised. Additionally, centenarians in both groups had lower neuroticism and higher conscientiousness than the US adult population. Findings suggest that the POPS is a psychometrically sound measure of personality in centenarians and capture personality aspects of extraversion, neuroticism, and conscientiousness, as well as dispositional optimism which may contribute to successful aging. ER -

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Morozevich GE, Kozlova NI, Ushakova NA, Preobrazhenskaya ME, Berman AE, . Integrin α5β1 simultaneously controls EGFR-dependent proliferation and Akt-dependent pro-survival signaling in epidermoid carcinoma cells. . 4:368-374. https://doi.org/10.18632/aging.100457

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Provider: TY - JOUR AU - Morozevich, Galina E AU - Kozlova, Nadezda I AU - Ushakova, Natalia A AU - Preobrazhenskaya, Marina E AU - Berman, Albert E TI - Integrin α5β1 simultaneously controls EGFR-dependent proliferation and Akt-dependent pro-survival signaling in epidermoid carcinoma cells JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100457 DO - 10.18632/aging.100457 SP - 368 EP - 374 PY - ER -

Provider: TY - JOUR AU - Morozevich, Galina E AU - Kozlova, Nadezda I AU - Ushakova, Natalia A AU - Preobrazhenskaya, Marina E AU - Berman, Albert E TI - Integrin α5β1 simultaneously controls EGFR-dependent proliferation and Akt-dependent pro-survival signaling in epidermoid carcinoma cells JO - JA - VL - 4 IS - 5 PB - SN - UR - https://doi.org/10.18632/aging.100457 DO - 10.18632/aging.100457 SP - 368 EP - 374 PY - AB - To delineate distinctive role of the components of α5β1 integrin-EGFR axis in control of epidermoid carcinoma cell proliferation, we performed individual inhibition of α5β1 and EGFR via genetic and phamacological methods, respectively. We demonstrated that pharmacological inhibition of epidermal growth factor receptor (EGFR) significantly affected proliferation of A431 human cells by inducing the G0/G1 cell cycle arrest, whereas shRNA-mediated depletion of α5 subunit of α5β1 integrin led to a similar type of cell cycle arrest followed by significant apoptosis. Both treatments resulted in suppression of activated (phosphorylated) forms of focal adhesion kinase (FAK) and Erk. However, unlike EGFR inhibition, depletion of α5 led to substantial suppression of AKT activity. Accordingly, pharmacological inhibition of EGFR and AKT recapitulated detrimental effects caused by shRNA-mediated depletion of α5. Moreover, depletion of α5 led to a severe drop in the amounts of active EGFR. Thus, for the first time, we demonstrated that α5β1 integrin simultaneously maintains pro-survival signaling via continuous activation of AKT and up-regulates proliferation via activation of EGFR. ER -

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