Research Paper Volume 13, Issue 13 pp 17253—17273

Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis

Wenyi Lin1, *, , Yu Wu2, *, , Xuan Lu1, , Yu Hu1, ,

  • 1 Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • 2 Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
* Equal contribution

Received: November 6, 2020       Accepted: May 31, 2021       Published: July 2, 2021
How to Cite

Copyright: © 2021 Lin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Platelet activation plays an important role in the progression of pulmonary embolism (PE). Mean platelet volume (MPV) can serve as a marker of platelet activity in patients with PE. Many studies have reported different results regarding the relationship. Therefore, we aimed to perform a systematic review and meta-analysis to evaluate the relationship between MPV and PE. Two reviewers independently searched relevant articles in databases from inception to April 21, 2021 and identified all studies on MPV and PE as the outcomes of interest. Further, we selected studies meeting the criteria and extracted the data. Of the 2505 publications identified, we included 18 studies after screening. Results showed MPV was significantly higher in patients with PE (0.83 fL, 95% CI: 0.38-1.28, P<0.001) than in controls. The mean difference in MPV between those who died and survivors of PE was 1.23 fL (95% CI: 0.96-1.51, P<0.001). Hence, an increased MPV is associated with PE. MPV could be a useful tool to predict the occurrence and death risk of PE together with other risk factors.


PE: Pulmonary embolism; MPV: Mean platelet volume; CTPA: Computed tomography pulmonary angiography; MRI: Magnetic resonance imaging; MD: Mean difference; SD: Standard deviation; OR: Odds ratios; RR: Risk ratios; HR: Hazard ratios; CI: Confidence intervals; EDTA: Ethylenediaminetetraacetic acid; DVT: Deep vein thrombosis; NOS: Newcastle–Ottawa Scale; WMD: Weighted mean differences; I2: I-square; VTE: venous thromboembolism; PTE: Pulmonary thromboembolism.