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The cover features Figure 8 "Illustration depicting cellular and molecular changes in MLE12 cells undergoing our 7-day injury model“ from Shaghaghi et al.

Volume 13, Issue 13

15 July, 2021
pp 16898—17954

About the Cover

The cover features Figure 8 "Illustration depicting cellular and molecular changes in MLE12 cells undergoing our 7-day injury model“ from Shaghaghi et al.


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Editorials

Epigenetic regulation of drug metabolism in aging

Joseph L. McClay,
https://doi.org/10.18632/aging.203312 pp 16898—16899
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Cognitive management in a digital world

Michelle Gray, Joshua L. Gills, Jordan M. Glenn,
https://doi.org/10.18632/aging.203324 pp 16900—16901
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Senescence in neurons: an open issue

Jordi Bruna, Aina Calls, Victor J. Yuste,
https://doi.org/10.18632/aging.203329 pp 16902—16903
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Research Papers

COVID-19
Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2

Jintian Wang, Yunjiang Liu, Shuo Zhang,
https://doi.org/10.18632/aging.203229 pp 16904—16921
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A model of the aged lung epithelium in idiopathic pulmonary fibrosis

Hoora Shaghaghi, Karina Cuevas-Mora, Rachel Para, Cara Tran, Willy Roque, Matthew J. Robertson, Ivan O. Rosas, Ross Summer, Freddy Romero,
https://doi.org/10.18632/aging.203291 pp 16922—16937
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Macrophage phenotype and function are dependent upon the composition and biomechanics of the local cardiac tissue microenvironment

Martin Haschak, Samuel LoPresti, Elizabeth Stahl, Siddhartha Dash, Branimir Popovich, Bryan N. Brown,
https://doi.org/10.18632/aging.203054 pp 16938—16956
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The dual distinct role of telomerase in repression of senescence and myofibroblast differentiation

Masanori Harada, Biao Hu, Jeffrey Lu, Jing Wang, Andrew E. Rinke, Zhe Wu, Tianju Liu, Sem H. Phan,
https://doi.org/10.18632/aging.203246 pp 16957—16973
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The risk of Alzheimer’s disease according to dynamic changes in metabolic health and obesity: a nationwide population-based cohort study

Yun Kyung Cho, Jiwoo Lee, Hwi Seung Kim, Joong-Yeol Park, Woo Je Lee, Ye-Jee Kim, Chang Hee Jung,
https://doi.org/10.18632/aging.203255 pp 16974—16989
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Sex differences in genetic and environmental influences on frailty and its relation to body mass index and education

Jonathan K. L. Mak, Chandra A. Reynolds, Sara Hägg, Xia Li, Malin Ericsson, Nancy L. Pedersen, Juulia Jylhävä, Ralf Kuja-Halkola,
https://doi.org/10.18632/aging.203262 pp 16990—17023
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Prevalence and predictors of subclinical atrial fibrillation in hospitalized older adults

Francesco Spannella, Federico Giulietti, Lorenzo Pimpini, Francesca Elena Lombardi, Serena Re, Paola Schiavi, Gina Dragano, Roberto Antonicelli, Riccardo Sarzani,
https://doi.org/10.18632/aging.203270 pp 17024—17037
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Lifetime depression and age-related changes in body composition, cardiovascular function, grip strength and lung function: sex-specific analyses in the UK Biobank

Julian Mutz, Cathryn M. Lewis,
https://doi.org/10.18632/aging.203275 pp 17038—17079
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Joint trajectories of episodic memory and odor identification in older adults: patterns and predictors

Christina S. Dintica, Miriam L. Haaksma, Jonas K. Olofsson, David A. Bennett, Weili Xu,
https://doi.org/10.18632/aging.203280 pp 17080—17096
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Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43

Paul Dent, Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Derek Cridebring, Eric M. Reiman,
https://doi.org/10.18632/aging.203297 pp 17097—17117
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Human adipose-derived stem cells promote seawater-immersed wound healing via proangiogenic effects

Jiachao Xiong, Hong Qiang, Ting Li, Jiayi Zhao, Ziyu Wang, Fei Li, Jianwen Xu,
https://doi.org/10.18632/aging.202773 pp 17118—17136
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Machine-intelligence for developing a potent signature to predict ovarian response to tailor assisted reproduction technology

Sisi Yan, Wenyi Jin, Jinli Ding, Tailang Yin, Yi Zhang, Jing Yang,
https://doi.org/10.18632/aging.203032 pp 17137—17154
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Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis

Zi-Jiang Zhu, Yao Pang, Gang Jin, Hong-Yi Zhang, Wen-Hao Wang, Jia-Wei Liu, Guang-Xin Tuo, Peng Wu, Yi Yang, Ze-Quan Wang, Kui Wang,
https://doi.org/10.18632/aging.203062 pp 17155—17176
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Carbon nanotubes (CNT)-loaded ginsenosides Rb3 suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer

Xiao Luo, Hui Wang, Degang Ji,
https://doi.org/10.18632/aging.203131 pp 17177—17189
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miR-424-5p shuttled by bone marrow stem cells-derived exosomes attenuates osteogenesis via regulating WIF1-mediated Wnt/β-catenin axis

Yongkun Wei, Huiling Ma, Haiqing Zhou, Hanrong Yin, Jie Yang, Yongcai Song, Binhui Yang,
https://doi.org/10.18632/aging.203169 pp 17190—17201
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Zhoushi Qiling decoction induces apoptosis of human prostate cancer cells via miR-143/Bcl-2 axis

Hongwen Cao, Dan Wang, Renjie Gao, Lei Chen, Yigeng Feng, Dongwen Gao,
https://doi.org/10.18632/aging.203171 pp 17202—17210
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Effects of long-term low dose saxitoxin exposure on nerve damage in mice

Qian Sun, Xiao Chen, Wei Liu, Shenpan Li, Yan Zhou, Xingfen Yang, Jianjun Liu,
https://doi.org/10.18632/aging.203199 pp 17211—17226
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miR-let-7c-5p and miR-149-5p inhibit proinflammatory cytokine production in osteoarthritis and rheumatoid arthritis synovial fibroblasts

Yat-Yin Law, Wei-Fang Lee, Chin-Jung Hsu, Yen-You Lin, Chun-Hao Tsai, Chien-Chung Huang, Min-Huan Wu, Chih-Hsin Tang, Ju-Fang Liu,
https://doi.org/10.18632/aging.203201 pp 17227—17236
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Association between Alzheimer’s disease genes and trajectories of cognitive function decline in Han Chinese in Taiwan

Tsung-Jen Hsieh, Wei-Ju Lee, Yi-Chu Liao, Chih-Cheng Hsu, Yao-Hwei Fang, Tzu-Yu Chen, Yung-Shuan Lin, I-Shou Chang, Shuu-Jiun Wang, Chao A. Hsiung, Jong-Ling Fuh, Alzheimer’s Disease Neuroimaging Initiative,
https://doi.org/10.18632/aging.203204 pp 17237—17252
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Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis

Wenyi Lin, Yu Wu, Xuan Lu, Yu Hu,
https://doi.org/10.18632/aging.203205 pp 17253—17273
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Circ_0081001 down-regulates miR-494-3p to enhance BACH1 expression and promotes osteosarcoma progression

Shizhang Liu, Keke Duan, Xiaoxia Zhang, Xiane Cao, Xixia Wang, Fanbin Meng, Huitong Liu, Bingqiang Xu, Xi Wang,
https://doi.org/10.18632/aging.203207 pp 17274—17284
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Knockdown of lncRNA ZNRD1-AS1 suppresses gastric cancer cell proliferation and metastasis by targeting the miR-9-5p/HSP90AA1 axis

Ming-Chen Ba, Zheng Ba, Yuan-Feng Gong, Kun-Peng Lin, Yin-Bing Wu, Yi-Nuo Tu,
https://doi.org/10.18632/aging.203209 pp 17285—17301
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Bioinformatics analysis for the identification of key genes and long non-coding RNAs related to bone metastasis in breast cancer

Xu Teng, Tianshu Yang, Wei Huang, Weishi Li, Lin Zhou, Zihang Wang, Yajuan Feng, Jingyao Zhang, Xin Yin, Pei Wang, Gen Li, Hefeng Yu, Zhongqiang Chen, Dongwei Fan,
https://doi.org/10.18632/aging.203211 pp 17302—17315
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Anoctamin 5 promotes osteosarcoma development by increasing degradation of Nel-like proteins 1 and 2

Runsang Pan, Qiaoying Lu, Chong Ren, Hao Li, Fanqiang Zeng, Xiaobin Tian, Houping Chen,
https://doi.org/10.18632/aging.203212 pp 17316—17327
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Plasma cell-free circRNAs panel act as fingerprint predicts the occurrence of laryngeal squamous cell carcinoma

Jiahui Han, Qiuhong Lin, Chunguang Dong,
https://doi.org/10.18632/aging.203215 pp 17328—17336
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Age as a modifier of the effects of chemoradiotherapy with infusional 5-fluorouracil after D2 dissection in gastric cancer

Hung-Chang Wu, Wen-Li Lin, Chien-Liang Lin, Cheng-Yao Lin, Shang-Wen Chen, Yan-Xun Chen, Chao-Hsun Chen, Sung-Wei Lee, Shang-Hung Chen, Chao-Jung Tsao, Wen-Tsung Huang, How-Ran Guo,
https://doi.org/10.18632/aging.203223 pp 17337—17348
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miR-144-3p inhibited the growth, metastasis and epithelial-mesenchymal transition of colorectal adenocarcinoma by targeting ZEB1/2

Taiyuan Li, Cheng Tang, Zhixiang Huang, Lingling Yang, Hua Dai, Bo Tang, Benping Xiao, Jianfeng Li, Xiong Lei,
https://doi.org/10.18632/aging.203225 pp 17349—17369
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Baicalein ameliorates osteoporosis via AKT/FOXO1 signaling

Pan Cai, Yan Lu, Zhifeng Yin, Xiuhui Wang, Xiaoxiao Zhou, Zhuokai Li,
https://doi.org/10.18632/aging.203227 pp 17370—17379
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Trajectory patterns of blood pressure change up to six years and the risk of dementia: a nationwide cohort study

Gang Cheng, Simin He, Qiong He, Xiaowei Xie, Cai Tang, Qunhui Xie, Xihong Wu, Ni Jiang, Chao Li, Xianying Min, Yan Yan,
https://doi.org/10.18632/aging.203228 pp 17380—17406
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Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways

Linjuan Huang, Ling Zhao, Jing Zhang, Fang He, Hao Wang, Qing Liu, Deyao Shi, Na Ni, William Wagstaff, Connie Chen, Russell R. Reid, Rex C. Haydon, Hue H. Luu, Le Shen, Tong-Chuan He, Liangdan Tang,
https://doi.org/10.18632/aging.203232 pp 17407—17427
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CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9

Menghai Zhu, Chong Lian, Gang Chen, Peng Zou, Beng Gang Qin,
https://doi.org/10.18632/aging.203233 pp 17428—17441
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Prognostic signatures associated with high infiltration of Tregs in bone metastatic prostate cancer

Fanjing Meng, Xu Han, Zhixue Min, Xuehui He, Sha Zhu,
https://doi.org/10.18632/aging.203234 pp 17442—17461
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miR-30a-5p suppresses lung squamous cell carcinoma via ATG5 - mediated autophagy

Jichen Yang, Sunyin Rao, Run Cao, Shouyong Xiao, Xin Cui, Lianhua Ye,
https://doi.org/10.18632/aging.203235 pp 17462—17472
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Activin receptor-like kinase 4 haplodeficiency alleviates the cardiac inflammation and pacing-induced ventricular arrhythmias after myocardial infarction

Yuli Yang, Qian Wang, Xingxing Cai, Zhixing Wei, Jianwen Hou, Yudong Fei, Wei Li, Yigang Li,
https://doi.org/10.18632/aging.203236 pp 17473—17488
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HDAC inhibitor Trichostatin A suppresses adipogenesis in 3T3-L1 preadipocytes

Xin Lv, Jun Qiu, Tao Hao, Haoran Zhang, Haiping Jiang, Yang Tan,
https://doi.org/10.18632/aging.203238 pp 17489—17498
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Downregulation of LINC00665 suppresses the progression of lung adenocarcinoma via regulating miR-181c-5p/ZIC2 axis

Wei Wei, Xiaoliang Zhao, Jiang Liu, Zhenfa Zhang,
https://doi.org/10.18632/aging.203240 pp 17499—17515
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Glycolysis- and immune-related novel prognostic biomarkers of Ewing's sarcoma: glucuronic acid epimerase and triosephosphate isomerase 1

Jie Jiang, Xinli Zhan, Guoyong Xu, Tuo Liang, Chaojie Yu, Shian Liao, Liyi Chen, Shengsheng Huang, Xuhua Sun, Ming Yi, Zide Zhang, Yuanlin Yao, Chong Liu,
https://doi.org/10.18632/aging.203242 pp 17516—17535
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IGF IIRα-triggered pathological manifestations in the heart aggravate renal inflammation in STZ-induced type-I diabetes rats

Henry Cherng-Han Lin, Catherine Reena Paul, Chia-Hua Kuo, Yung-Hsien Chang, William Shao-Tsu Chen, Tsung-Jung Ho, Cecilia Hsuan Day, Vijaya Padma Viswanadha, Yuhsin Tsai, Chih-Yang Huang,
https://doi.org/10.18632/aging.203244 pp 17536—17547
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Comprehensive analysis of the prognosis and immune infiltration for CXC chemokines in colorectal cancer

Xi Yang, Yuanfeng Wei, Feng Sheng, Yirong Xu, Jiao Liu, Ling Gao, Ju Yang, Xinchen Sun, Junxing Huang, Qing Guo,
https://doi.org/10.18632/aging.203245 pp 17548—17567
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Aging-dependent loss of GAP junction proteins Cx46 and Cx50 in the fiber cells of human and mouse lenses accounts for the diminished coupling conductance

Xiao-Dong Gong, Yan Wang, Xue-Bin Hu, Shu-Yu Zheng, Jia-Ling Fu, Qian Nie, Ling Wang, Min Hou, Jia-Wen Xiang, Yuan Xiao, Qian Gao, Yue-Yue Bai, Yi-Zhi Liu, David Wan-Cheng Li,
https://doi.org/10.18632/aging.203247 pp 17568—17591
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DNA methylation biomarkers for diagnosis of primary liver cancer and distinguishing hepatocellular carcinoma from intrahepatic cholangiocarcinoma

Yi Bai, Wen Tong, Fucun Xie, Liuyang Zhu, Hao Wu, Rui Shi, Lianjiang Wang, Long Yang, Zhisong Liu, Fei Miao, Qiang Zhao, Yaming Zhang,
https://doi.org/10.18632/aging.203249 pp 17592—17606
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Comprehensive analysis of an immune-related ceRNA network in identifying a novel lncRNA signature as a prognostic biomarker for hepatocellular carcinoma

Rui Chen, Yunlong Chen, Wenjie Huang, Yingnan Zhao, Wang Luo, Jinyu Lin, Zhuangxiong Wang, Jian Yang,
https://doi.org/10.18632/aging.203250 pp 17607—17628
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Association of dietary tomato intake with bladder cancer risk in a prospective cohort of 101,683 individuals with 12.5 years of follow-up

Xin Xu, Bo Xie, Shiqi Li, Shuo Wang, Dan Xia, Hongzhou Meng,
https://doi.org/10.18632/aging.203252 pp 17629—17637
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Pretreatment neutrophil-to-lymphocyte ratio predicts the benefit of gastric cancer patients with systemic therapy

Songtao Du, Zhenhao Fang, Lin Ye, Huiyan Sun, Guangtong Deng, Wei Wu, Furong Zeng,
https://doi.org/10.18632/aging.203256 pp 17638—17654
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Characterization of ferroptosis signature to evaluate the predict prognosis and immunotherapy in glioblastoma

Xiaopeng Zhu, Yuxiang Zhou, Yangqian Ou, Zebo Cheng, Deqing Han, Zhou Chu, Sian Pan,
https://doi.org/10.18632/aging.203257 pp 17655—17672
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Circular RNA circCCDC66 promotes glioma proliferation by acting as a ceRNA for miR-320a to regulate FOXM1 expression

Ling Qi, Weiyao Wang, Guifang Zhao, Hong Jiang, Yu Zhang, Donghai Zhao, Hong Jin, Haiyang Xu, Hongquan Yu,
https://doi.org/10.18632/aging.203258 pp 17673—17689
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α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice

Huawei Zhang, Sunlong Li, Jiajie Lu, Jie Jin, Gaosheng Zhu, Libo Wang, Yingzhao Yan, Linjie He, Ben Wang, Xiangyang Wang, Huachen Yu,
https://doi.org/10.18632/aging.203259 pp 17690—17706
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Screening and identification of angiogenesis-related genes as potential novel prognostic biomarkers of hepatocellular carcinoma through bioinformatics analysis

Zili Zhen, Zhemin Shen, Yanmei Hu, Peilong Sun,
https://doi.org/10.18632/aging.203260 pp 17707—17733
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Clinical significance and prognostic role of an immune-related gene signature in gastric adenocarcinoma

Rui Mao, Kehao Liu, Nana Zhao, Pengsen Guo, Yingxin Wu, Zheng Wang, Yanjun Liu, Tongtong Zhang,
https://doi.org/10.18632/aging.203266 pp 17734—17767
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Methylation silencing CDH23 is a poor prognostic marker in diffuse large B-cell lymphoma

Baoping Cao, Xiaochuan Guo, Lefu Huang, Bin Wang, Weixia Wang, Dong Han, Weijing Zhang, Kaili Zhong,
https://doi.org/10.18632/aging.203268 pp 17768—17788
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Bioinformatics analysis of the role of CXC ligands in the microenvironment of head and neck tumor

Fengyang Jing, Jianxiong Wang, Liming Zhou, Yujie Ning, Shengqian Xu, Youming Zhu,
https://doi.org/10.18632/aging.203269 pp 17789—17817
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Particulate matter exposure is highly correlated to pediatric asthma exacerbation

Xin Yang, Yuanyuan Zhang, Xueqin Zhan, Xuchen Xu, Shuxian Li, Xuefeng Xu, Songmin Ying, Zhimin Chen,
https://doi.org/10.18632/aging.203281 pp 17818—17829
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Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression

Yan Zhang, Huayun Zhu, Ning Sun, Xiaomei Zhang, Geyu Liang, Jiali Zhu, Lei Xia, Yingying Kou, Jianwei Lu,
https://doi.org/10.18632/aging.203286 pp 17830—17846
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Prognostic value of fatty acid metabolism-related genes in patients with hepatocellular carcinoma

Dongsheng He, Lifang Cai, Weiming Huang, Qingqing Weng, Xi Lin, Mengxing You, Shengyin Liao,
https://doi.org/10.18632/aging.203288 pp 17847—17863
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A innovative prognostic symbol based on neutrophil extracellular traps (NETs)-related lncRNA signature in non-small-cell lung cancer

Chen Fang, Fen Liu, Yong Wang, Shangkun Yuan, Renfang Chen, Xiaotong Qiu, Xiaoying Qian, Xinwei Zhang, Zhehao Xiao, Qian Wang, Biqi Fu, Yong Li,
https://doi.org/10.18632/aging.203289 pp 17864—17879
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Anti-aging effects of a functional food via the action of gut microbiota and metabolites in aging mice

Jie Zhang, Zhewen Chen, Huaixi Yu, Yanwen Lu, Weinan Yu, Mingyong Miao, Hanping Shi,
https://doi.org/10.18632/aging.202873 pp 17880—17900
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Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3

Chenglong Chen, Hongliang Zhang, Yiyang Yu, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou, Tingting Ren, Yi Huang, Wei Guo,
https://doi.org/10.18632/aging.203196 pp 17901—17913
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Roxadustat for the treatment of anemia in patients with chronic kidney diseases: a meta-analysis

Li Zhang, Jie Hou, Jia Li, Sen-Sen Su, Shuai Xue,
https://doi.org/10.18632/aging.203143 pp 17914—17929
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Review

Research progress of melatonin (MT) in improving ovarian function: a review of the current status

Yi Ming Guo, Tie Cheng Sun, Hui Ping Wang, Xi Chen,
https://doi.org/10.18632/aging.203231 pp 17930—17947
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Corrections

Correction for: Prediction of cognitive performance in old age from spatial probability maps of white matter lesions

Cui Zhao, Ying Liang, Ting Chen, Yihua Zhong, Xianglong Li, Jing Wei, Chunlin Li, Xu Zhang,
https://doi.org/10.18632/aging.203325 pp 17948
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Correction for: Aucubin exerts anti-osteoporotic effects by promoting osteoblast differentiation

Yutong Li, Yongfeng Zhang, Xinrui Zhang, Wenqian Lu, Xin Liu, Min Hu, Di Wang,
https://doi.org/10.18632/aging.203365 pp 17949—17952
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Correction for: STAT5A induced LINC01198 promotes proliferation of glioma cells through stabilizing DGCR8

Cheng Tan, Yimeng Dai, Xiaoyang Liu, Guifang Zhao, Weiyao Wang, Jia Li, Ling Qi,
https://doi.org/10.18632/aging.203346 pp 17953—17954
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