Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 11, Issue 12

30 June, 2019
pp 3891—4299

About the Cover

The cover features Figure 2 "Modulation of autophagy by α-ketoglutarate precursors" from Zhang et al.

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Editorials

Senescence utilises inflammatory caspases to drive SASP

Kimberley A. Wiggins, Murray CH. Clarke,

https://doi.org/10.18632/aging.102031 pp 3891—3892

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Microbiota and the clock: sexual dimorphism matters!

Benjamin D. Weger, Frédéric Gachon,

https://doi.org/10.18632/aging.102051 pp 3893—3894

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Phospholipid metabolism regulates AML growth and stemness

Mingjing Xu, Ayesh K. Seneviratne, Aaron D. Schimmer,

https://doi.org/10.18632/aging.102055 pp 3895—3897

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Itaconate as an immune modulator

Anaísa V. Ferreira, Mihai G. Netea, Jorge Domínguez-Andrés,

https://doi.org/10.18632/aging.102057 pp 3898—3899

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Research Papers

Mesenchymal stem cells rejuvenate cardiac muscle through regulating macrophage polarization

Busheng Zhang, Naishi Zhao, Jing Zhang, Yu Liu, Dan Zhu, Ye Kong,

https://doi.org/10.18632/aging.102009 pp 3900—3908

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Alda-1 attenuates hyperoxia-induced mitochondrial dysfunction in lung vascular endothelial cells

Sahebgowda Sidramagowda Patil, Helena Hernández-Cuervo, Jutaro Fukumoto, Venkata Ramireddy Narala, Smita Saji, Monica Borra, Matthew Alleyn, Muling Lin, Ramani Soundararajan, Richard Lockey, Narasaiah Kolliputi, Lakshmi Galam,

https://doi.org/10.18632/aging.102012 pp 3909—3918

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Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging

Man Zhang, Muhammed Burak Bener, Zongliang Jiang, Tianren Wang, Ecem Esencan, Richard Scott III, Tamas Horvath, Emre Seli,

https://doi.org/10.18632/aging.102024 pp 3919—3938

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B7-CD28 gene family expression is associated with prognostic and immunological characteristics of diffuse large B-cell lymphoma

Gangjian Wang, Xiaorui Fu, Yu Chang, Xin Li, Xiaolong Wu, Ling Li, Lei Zhang, Zhenchang Sun, Xudong Zhang, Mingzhi Zhang,

https://doi.org/10.18632/aging.102025 pp 3939—3957

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Prevalence and predisposing factors of depressive symptoms in patients with stable coronary artery disease: a cross-sectional single-center study

Yeshun Wu, Bin Zhu, Zijun Chen, Jiahao Duan, Ailin Luo, Ling Yang, Chun Yang,

https://doi.org/10.18632/aging.102026 pp 3958—3968

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AGTR1 promotes lymph node metastasis in breast cancer by upregulating CXCR4/SDF-1α and inducing cell migration and invasion

Yuxi Ma, Zihan Xia, Chunmei Ye, Chong Lu, Sheng Zhou, Juan Pan, Cuiwei Liu, Jieying Zhang, Tao Liu, Ting Hu, Linka Xie, Gang Wu, Yanxia Zhao,

https://doi.org/10.18632/aging.102032 pp 3969—3992

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Intermediate metabolites of the pyrimidine metabolism pathway extend the lifespan of C. elegans through regulating reproductive signals

Qin-Li Wan, Xiao Meng, Xiaodie Fu, Bohui Chen, Jing Yang, Hengwen Yang, Qinghua Zhou,

https://doi.org/10.18632/aging.102033 pp 3993—4010

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A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass

Xuehui Liu, Lei Wei, Qiongye Dong, Liyang Liu, Michael Q. Zhang, Zhen Xie, Xiaowo Wang,

https://doi.org/10.18632/aging.102034 pp 4011—4031

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Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation

Hong-Xia Zheng, Yuan Zhao, Ying Xu, Zi-Jia Zhang, Jing-jing Zhu, Yuan-Fang Fan, Na Lin,

https://doi.org/10.18632/aging.102035 pp 4032—4049

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TRPM7 channel inhibition exacerbates pulmonary arterial hypertension through MEK/ERK pathway

Junhui Xing, Mengyu Wang, Jin Hong, Yueqiao Gao, Yuzhou Liu, Heping Gu, Jianzeng Dong, Ling Li,

https://doi.org/10.18632/aging.102036 pp 4050—4065

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Anti-aging interventions affect lifespan variability in sex, strain, diet and drug dependent fashion

Andrzej Bartke, Tracy R. Evans, C.J.M. Musters,

https://doi.org/10.18632/aging.102037 pp 4066—4074

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TGF-β1 enhances FOXO3 expression in human synovial fibroblasts by inhibiting miR-92a through AMPK and p38 pathways

Shu-Jui Kuo, Shan-Chi Liu, Yuan-Li Huang, Chun-Hao Tsai, Yi-Chin Fong, Horng-Chaung Hsu, Chih-Hsin Tang,

https://doi.org/10.18632/aging.102038 pp 4075—4089

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Cognitive compensatory mechanisms in normal aging: a study on verbal fluency and the contribution of other cognitive functions

Lissett Gonzalez-Burgos, Juan Andrés Hernández-Cabrera, Eric Westman, José Barroso, Daniel Ferreira,

https://doi.org/10.18632/aging.102040 pp 4090—4106

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Grape seed proanthocyanidins ameliorate neuronal oxidative damage by inhibiting GSK-3β-dependent mitochondrial permeability transition pore opening in an experimental model of sporadic Alzheimer’s disease

Qinru Sun, Ning Jia, Xin Li, Jie Yang, Guomin Chen,

https://doi.org/10.18632/aging.102041 pp 4107—4124

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Altered FoxO1 and PPARγ interaction in age-related ER stress-induced hepatic steatosis

Dae Hyun Kim, Sugyeong Ha, Yeon Ja Choi, H. Henry Dong, Byung Pal Yu, Hae Young Chung,

https://doi.org/10.18632/aging.102042 pp 4125—4144

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Intestinal stem cells acquire premature senescence and senescence associated secretory phenotype concurrent with persistent DNA damage after heavy ion radiation in mice

Santosh Kumar, Shubhankar Suman, Albert J Fornace Jr., Kamal Datta,

https://doi.org/10.18632/aging.102043 pp 4145—4158

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Proteomics-based identification of different training adaptations of aged skeletal muscle following long-term high-intensity interval and moderate-intensity continuous training in aged rats

Fang-Hui Li, Lei Sun, Da-Shuai Wu, Hao-En Gao, Zhu Min,

https://doi.org/10.18632/aging.102044 pp 4159—4182

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Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

Yuan Su, Tao Wang, Nan Wu, Diyan Li, Xiaolan Fan, Zhongxian Xu, Shailendra Kumar Mishra, Mingyao Yang,

https://doi.org/10.18632/aging.102045 pp 4183—4197

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Integrated multi-omics analysis of genomics, epigenomics, and transcriptomics in ovarian carcinoma

Mingjun Zheng, Yuexin Hu, Rui Gou, Jing Wang, Xin Nie, Xiao Li, Qing Liu, Juanjuan Liu, Bei Lin,

https://doi.org/10.18632/aging.102047 pp 4198—4215

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β-catenin-mediated hair growth induction effect of 3,4,5-tri-O-caffeoylquinic acid

Meriem Bejaoui, Myra O. Villareal, Hiroko Isoda,

https://doi.org/10.18632/aging.102048 pp 4216—4237

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Placental epigenetic clocks: estimating gestational age using placental DNA methylation levels

Yunsung Lee, Sanaa Choufani, Rosanna Weksberg, Samantha L. Wilson, Victor Yuan, Amber Burt, Carmen Marsit, Ake T. Lu, Beate Ritz, Jon Bohlin, Håkon K. Gjessing, Jennifer R. Harris, Per Magnus, Alexandra M. Binder, Wendy P. Robinson, Astanand Jugessur, Steve Horvath,

https://doi.org/10.18632/aging.102049 pp 4238—4253

View Abstract PDF Full-Text How to Cite Special Collection on Steve Horvath's Publications in Aging (Albany NY)

Sulfate assimilation regulates hydrogen sulfide production independent of lifespan and reactive oxygen species under methionine restriction condition in yeast

Kyung-Mi Choi, Sorah Kim, Seahyun Kim, Hae Min Lee, Alaattin Kaya, Bok-Hwan Chun, Yong Kwon Lee, Tae-Sik Park, Cheol-Koo Lee, Seong-il Eyun, Byung Cheon Lee,

https://doi.org/10.18632/aging.102050 pp 4254—4273

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Review

The interplay between mineral metabolism, vascular calcification and inflammation in Chronic Kidney Disease (CKD): challenging old concepts with new facts

Carla Viegas, Nuna Araújo, Catarina Marreiros, Dina Simes,

https://doi.org/10.18632/aging.102046 pp 4274—4299

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Featured Nobel Articles

Volume 11, Issue 12

About the Cover

Editorials

Kimberley A. Wiggins, Murray CH. Clarke,

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Benjamin D. Weger, Frédéric Gachon,

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Mingjing Xu, Ayesh K. Seneviratne, Aaron D. Schimmer,

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Anaísa V. Ferreira, Mihai G. Netea, Jorge Domínguez-Andrés,

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Research Papers

Busheng Zhang, Naishi Zhao, Jing Zhang, Yu Liu, Dan Zhu, Ye Kong,

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Sahebgowda Sidramagowda Patil, Helena Hernández-Cuervo, Jutaro Fukumoto, Venkata Ramireddy Narala, Smita Saji, Monica Borra, Matthew Alleyn, Muling Lin, Ramani Soundararajan, Richard Lockey, Narasaiah Kolliputi, Lakshmi Galam,

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Man Zhang, Muhammed Burak Bener, Zongliang Jiang, Tianren Wang, Ecem Esencan, Richard Scott III, Tamas Horvath, Emre Seli,

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Gangjian Wang, Xiaorui Fu, Yu Chang, Xin Li, Xiaolong Wu, Ling Li, Lei Zhang, Zhenchang Sun, Xudong Zhang, Mingzhi Zhang,

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Yeshun Wu, Bin Zhu, Zijun Chen, Jiahao Duan, Ailin Luo, Ling Yang, Chun Yang,

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Yuxi Ma, Zihan Xia, Chunmei Ye, Chong Lu, Sheng Zhou, Juan Pan, Cuiwei Liu, Jieying Zhang, Tao Liu, Ting Hu, Linka Xie, Gang Wu, Yanxia Zhao,

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Qin-Li Wan, Xiao Meng, Xiaodie Fu, Bohui Chen, Jing Yang, Hengwen Yang, Qinghua Zhou,

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Xuehui Liu, Lei Wei, Qiongye Dong, Liyang Liu, Michael Q. Zhang, Zhen Xie, Xiaowo Wang,

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Hong-Xia Zheng, Yuan Zhao, Ying Xu, Zi-Jia Zhang, Jing-jing Zhu, Yuan-Fang Fan, Na Lin,

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Junhui Xing, Mengyu Wang, Jin Hong, Yueqiao Gao, Yuzhou Liu, Heping Gu, Jianzeng Dong, Ling Li,

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Andrzej Bartke, Tracy R. Evans, C.J.M. Musters,

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Shu-Jui Kuo, Shan-Chi Liu, Yuan-Li Huang, Chun-Hao Tsai, Yi-Chin Fong, Horng-Chaung Hsu, Chih-Hsin Tang,

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Lissett Gonzalez-Burgos, Juan Andrés Hernández-Cabrera, Eric Westman, José Barroso, Daniel Ferreira,

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Qinru Sun, Ning Jia, Xin Li, Jie Yang, Guomin Chen,

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Dae Hyun Kim, Sugyeong Ha, Yeon Ja Choi, H. Henry Dong, Byung Pal Yu, Hae Young Chung,

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