Online ISSN: 1945-4589

Volume 9, Issue 3

March 2017
pp 600—1083

About the Cover

The cover for issue 3 of Aging features the image ''Physiological frailty index as a measure of objective biological age in mammals" . The image is a courtesy of DG Photography. It illustrates Antoch et al.

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Table of Contents

Editorial

A laboratory test of evolutionary aging theories

Tatiana Iouk, Vladimir I. Titorenko,
https://doi.org/10.18632/aging.101215 pp 600—601
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Review

The histone variant H3.3 claims its place in the crowded scene of epigenetics

Daniele Bano, Antonia Piazzesi, Paolo Salomoni, Pierluigi Nicotera,
https://doi.org/10.18632/aging.101194 pp 602—614
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Priority Research Papers

Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice

Marina P. Antoch, Michelle Wrobel, Karen K. Kuropatwinski, Ilya Gitlin, Katerina I. Leonova, Ilia Toshkov, Anatoli S. Gleiberman, Alan D. Hutson, Olga B. Chernova, Andrei V. Gudkov,
https://doi.org/10.18632/aging.101206 pp 615—626
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Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis

Roman Uzhachenko, Kelli Boyd, Danyvid Olivares-Villagomez, Yueming Zhu, J. Shawn Goodwin, Tanu Rana, Anil Shanker, Winston J.T. Tan, Tanya Bondar, Ruslan Medzhitov, Alla V. Ivanova,
https://doi.org/10.18632/aging.101213 pp 627—649
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Research Papers

Frailty and inflammatory markers in older adults with cancer

Tomohiro F. Nishijima, Allison M. Deal, Grant R. Williams, Emily J. Guerard, Kirsten A. Nyrop, Hyman B. Muss,
https://doi.org/10.18632/aging.101162 pp 650—664
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Lesion complexity drives age related cancer susceptibility in human mammary epithelial cells

Deepa M. Sridharan, Shiena Enerio, Mark A. LaBarge, Martha M. Stampfer, Janice M. Pluth,
https://doi.org/10.18632/aging.101183 pp 665—686
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Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion

Janice M. Leung, Nick Fishbane, Meaghan Jones, Alexander Morin, Stella Xu, Joseph CY Liu, Julie MacIsaac, M-J Milloy, Kanna Hayashi, Julio Montaner, Steve Horvath, Michael Kobor, Don D. Sin, P. Richard Harrigan, S.F. Paul Man,
https://doi.org/10.18632/aging.101184 pp 687—705
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Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption

Sana Siddiqui, Ana Lustig, Arnell Carter, Mathavi Sankar, Caitlin M. Daimon, Richard T. Premont, Harmonie Etienne, Jaana van Gastel, Abdelkrim Azmi, Jonathan Janssens, Kevin G. Becker, Yongqing Zhang, William Wood III, Elin Lehrmann, James G. Martin, Bronwen Martin, Dennis D. Taub, Stuart Maudsley,
https://doi.org/10.18632/aging.101185 pp 706—740
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Patterns of brain atrophy associated with episodic memory and semantic fluency decline in aging

Amandine Pelletier, Charlotte Bernard, Bixente Dilharreguy, Catherine Helmer, Melanie Le Goff, Sandra Chanraud, Jean-François Dartigues, Michèle Allard, Hélène Amieva, Gwénaëlle Catheline,
https://doi.org/10.18632/aging.101186 pp 741—752
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Methylome-wide association study of whole blood DNA in the Norfolk Island isolate identifies robust loci associated with age

Miles C. Benton, Heidi G. Sutherland, Donia Macartney-Coxson, Larisa M. Haupt, Rodney A. Lea, Lyn R. Griffiths,
https://doi.org/10.18632/aging.101187 pp 753—768
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Individualizing treatment targets for elderly patients with type 2 diabetes: factors influencing clinical decision making in the 24-week, randomized INTERVAL study

W. David Strain, Abhijit S. Agarwal, Päivi M. Paldánius,
https://doi.org/10.18632/aging.101188 pp 769—777
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Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification

Matilde Alique, María Piedad Ruíz-Torres, Guillermo Bodega, María Victoria Noci, Nuria Troyano, Lourdes Bohórquez, Carlos Luna, Rafael Luque, Andrés Carmona, Julia Carracedo, Rafael Ramírez,
https://doi.org/10.18632/aging.101191 pp 778—789
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Effect of intranasally administered insulin on cerebral blood flow and perfusion; a randomized experiment in young and older adults

Abimbola A. Akintola, Anna M. van Opstal, Rudi G. Westendorp, Iris Postmus, Jeroen van der Grond, Diana van Heemst,
https://doi.org/10.18632/aging.101192 pp 790—802
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Age-associated chromatin relaxation is enhanced in Huntington’s disease mice

Myungsun Park, Byungkuk Min, Kyuheum Jeon, Sunwha Cho, Jung Sun Park, Jisun Kim, Jeha Jeon, Jinhoi Song, Seokho Kim, Sangkyun Jeong, Hyemyung Seo, Yong-Kook Kang,
https://doi.org/10.18632/aging.101193 pp 803—822
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Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration

Pol Andrés-Benito, Jesús Moreno, Ester Aso, Mónica Povedano, Isidre Ferrer,
https://doi.org/10.18632/aging.101195 pp 823—851
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The TP53 gene rs1042522 C>G polymorphism and neuroblastoma risk in Chinese children

Jing He, Fenghua Wang, Jinhong Zhu, Zhuorong Zhang, Yan Zou, Ruizhong Zhang, Tianyou Yang, Huimin Xia,
https://doi.org/10.18632/aging.101196 pp 852—859
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Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells

Asim Ejaz, Monika Mattesich, Werner Zwerschke,
https://doi.org/10.18632/aging.101197 pp 860—879
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Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression

Kah Meng Lee, Kirat K. Chand, Luke A. Hammond, Nickolas A. Lavidis, Peter G. Noakes,
https://doi.org/10.18632/aging.101198 pp 880—899
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Circulating MiRNAs as biomarkers of gait speed responses to aerobic exercise training in obese older adults

Tan Zhang, Tina E. Brinkley, Keqin Liu, Xin Feng, Anthony P. Marsh, Stephen Kritchevsky, Xiaobo Zhou, Barbara J. Nicklas,
https://doi.org/10.18632/aging.101199 pp 900—913
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Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer

Xian-Zi Yang, Shu-Zhong Cui, Li-Si Zeng, Tian-Tian Cheng, Xiao-Xing Li, Jun Chi, Ren Wang, X.F. Steven Zheng, Hui-Yun Wang,
https://doi.org/10.18632/aging.101200 pp 914—931
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MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2

Tamara V. Werner, Martin Hart, Ruth Nickels, Yoo-Jin Kim, Michael D. Menger, Rainer M. Bohle, Andreas Keller, Nicole Ludwig, Eckart Meese,
https://doi.org/10.18632/aging.101201 pp 932—954
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New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Yi Zhu, Ewald J. Doornebal, Tamar Pirtskhalava, Nino Giorgadze, Mark Wentworth, Heike Fuhrmann-Stroissnigg, Laura J. Niedernhofer, Paul D. Robbins, Tamara Tchkonia, James L. Kirkland,
https://doi.org/10.18632/aging.101202 pp 955—963
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APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer’s Disease

Laila Abdullah, James E. Evans, Tanja Emmerich, Gogce Crynen, Ben Shackleton, Andrew P. Keegan, Cheryl Luis, Leon Tai, Mary J. LaDu, Michael Mullan, Fiona Crawford, Corbin Bachmeier,
https://doi.org/10.18632/aging.101203 pp 964—985
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Mouse mitochondrial lipid composition is defined by age in brain and muscle

Amelia K. Pollard, Catharine A. Ortori, Reinhard Stöger, David A. Barrett, Lisa Chakrabarti,
https://doi.org/10.18632/aging.101204 pp 986—998
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Long non-coding RNA LOC100129148 functions as an oncogene in human nasopharyngeal carcinoma by targeting miR-539-5p

Kai-Yu Sun, Tao Peng, Zhe Chen, Peng Song, Xu-Hong Zhou,
https://doi.org/10.18632/aging.101205 pp 999—1011
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MicroRNA-434-3p regulates age-related apoptosis through eIF5A1 in the skeletal muscle

Patricia S. Pardo, Ameena Hajira, Aladin M. Boriek, Junaith S. Mohamed,
https://doi.org/10.18632/aging.101207 pp 1012—1029
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The impact of pseudophakia on vision-related quality of life in the general population – The Gutenberg Health Study

Alexander K. Schuster, Norbert Pfeiffer, Andreas Schulz, Stefan Nickels, René Höhn, Philipp S. Wild, Maria Blettner, Thomas Münzel, Manfred E. Beutel, Karl J. Lackner, Urs Vossmerbaeumer,
https://doi.org/10.18632/aging.101208 pp 1030—1040
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Daily supplementation with GrandFusion® improves memory and learning in aged rats

Jin Yu, Hong Zhu, Stephen Perry, Saeid Taheri, Mark S. Kindy,
https://doi.org/10.18632/aging.101209 pp 1041—1054
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An epigenetic aging clock for dogs and wolves

Michael J. Thompson, Bridgett vonHoldt, Steve Horvath, Matteo Pellegrini,
https://doi.org/10.18632/aging.101211 pp 1055—1068
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Sirt6 deficiency results in progression of glomerular injury in the kidney

Wen Huang, Hua Liu, Shuang Zhu, Michael Woodson, Rong Liu, Ronald G. Tilton, Jordan D. Miller, Wenbo Zhang,
https://doi.org/10.18632/aging.101214 pp 1069—1083
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