Volume 12, Issue 7

Sex differences in out-of-hospital cardiac arrest

Iris Oving, Marieke T. Blom, Hanno L. Tan,

https://doi.org/10.18632/aging.102980 pp 5588—5589

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Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss

Jingjing Zhao, Gen Li, Xuan Zhao, Xin Lin, Yunge Gao, Nuno Raimundo, Geng-Lin Li, Wei Shang, Hao Wu, Lei Song,

https://doi.org/10.18632/aging.102977 pp 5590—5611

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Supraphysiological protection from replication stress does not extend mammalian lifespan

Eliene Albers, Alexandra Avram, Mauro Sbroggio, Oscar Fernandez-Capetillo, Andres J. Lopez-Contreras,

https://doi.org/10.18632/aging.103039 pp 5612—5624

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LncRNA 2310043L19Rik inhibits differentiation and promotes proliferation of myoblast by sponging miR-125a-5p

Rongyang Li, Bojiang Li, Ming Shen, Yan Cao, Xuan Zhang, Weijian Li, Jingli Tao, Wangjun Wu, Honglin Liu,

https://doi.org/10.18632/aging.102905 pp 5625—5639

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Inhibition of miR-19a partially reversed the resistance of colorectal cancer to oxaliplatin via PTEN/PI3K/AKT pathway

Ye Zhang, Xinxin Liu, Junying Zhang, Yuanyuan Xu, Jie Shao, Yue Hu, Peng Shu, Haibo Cheng,

https://doi.org/10.18632/aging.102929 pp 5640—5650

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Intermedin_1-53 attenuates aging-associated vascular calcification in rats by upregulating sirtuin 1

Yao Chen, Lin-Shuang Zhang, Jin-Ling Ren, Ya-Rong Zhang, Ning Wu, Mo-Zhi Jia, Yan-Rong Yu, Zhong-Ping Ning, Chao-Shu Tang, Yong-Fen Qi,

https://doi.org/10.18632/aging.102934 pp 5651—5674

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STAT5A induced LINC01198 promotes proliferation of glioma cells through stabilizing DGCR8

Cheng Tan, Yimeng Dai, Xiaoyang Liu, Guifang Zhao, Weiyao Wang, Jia Li, Ling Qi,

https://doi.org/10.18632/aging.102938 pp 5675—5692

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Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway

Mahmoud Al-Azab, Bing Wang, Abdalkhalig Elkhider, Williams Walana, Weiping Li, Bo Yuan, Yunshan Ye, Yawei Tang, Marwan Almoiliqy, Salah Adlat, Jing Wei, Yan Zhang, Xia Li,

https://doi.org/10.18632/aging.102958 pp 5693—5715

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Ube2s-stabilized β-catenin protects against myocardial ischemia/reperfusion injury by activating HIF-1α signaling

Xi Chen, Chiyao Wang, Pei Yang, Lei Shi, Haiyan Wang,

https://doi.org/10.18632/aging.102960 pp 5716—5732

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Immune gene signature delineates a subclass of thyroid cancer with unfavorable clinical outcomes

Jingtai Zhi, Jiaoyu Yi, Mengran Tian, Huijuan Wang, Ning Kang, Xiangqian Zheng, Ming Gao,

https://doi.org/10.18632/aging.102963 pp 5733—5750

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Molecular anatomy of the subcellular localization and nuclear import mechanism of herpes simplex virus 1 UL6

Mingsheng Cai, Xiaowen Ou, Yiwen Li, Xingmei Zou, Zuo Xu, Yuanfang Wang, Hao Peng, Yangxi Deng, Yingjie Guo, Manjiao Lu, Weidong Gan, Tao Peng, Meili Li,

https://doi.org/10.18632/aging.102965 pp 5751—5763

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CK1δ as a potential therapeutic target to treat bladder cancer

Yu-Chen Lin, Mei-Chuan Chen, Tsung-Han Hsieh, Jing-Ping Liou, Chun-Han Chen,

https://doi.org/10.18632/aging.102966 pp 5764—5780

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A novel germline gain-of-function HIF2A mutation in hepatocellular carcinoma with polycythemia

Jiong Yu, Xiaowei Shi, Chunzhang Yang, Petra Bullova, Christopher S. Hong, Cody L. Nesvick, Pauline Dmitriev, Karel Pacak, Zhengping Zhuang, Hongcui Cao, Lanjuan Li,

https://doi.org/10.18632/aging.102967 pp 5781—5791

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Decitabine in combination with low-dose cytarabine, aclarubicin and G-CSF tends to improve prognosis in elderly patients with high-risk AML

Ming Hong, Han Zhu, Qian Sun, Yu Zhu, Yi Miao, Hui Yang, Hai-Rong Qiu, Jian-Yong Li, Si-Xuan Qian,

https://doi.org/10.18632/aging.102973 pp 5792—5811

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Klotho antagonizes pulmonary fibrosis through suppressing pulmonary fibroblasts activation, migration, and extracellular matrix production: a therapeutic implication for idiopathic pulmonary fibrosis

Qiqing Huang, Yan Chen, Shaoran Shen, Yuanyuan Wang, Liya Liu, Shuangshuang Wu, Wei Xu, Weihong Zhao, Mingyan Lin, Jianqing Wu,

https://doi.org/10.18632/aging.102978 pp 5812—5831

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Development of a prognostic index and screening of potential biomarkers based on immunogenomic landscape analysis of colorectal cancer

Kang Lin, Jun Huang, Hongliang Luo, Chen Luo, Xiaojian Zhu, Fanqin Bu, Han Xiao, Li Xiao, Zhengming Zhu,

https://doi.org/10.18632/aging.102979 pp 5832—5857

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Renin-angiotensin-aldosterone system blockade is associated with higher risk of contrast-induced acute kidney injury in patients with diabetes

Mengqing Ma, Xin Wan, Min Gao, Binbin Pan, Dawei Chen, Qing Sun, Mengyu Zhang, Changgao Zhou, Tao Li, Hanchao Pan, Wei Shao, Zhihe Liu, Yue Chen, Changchun Cao,

https://doi.org/10.18632/aging.102982 pp 5858—5877

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Survival-associated alternative splicing signatures in non-small cell lung cancer

Deze Zhao, Chuantao Zhang, Man Jiang, Yongjie Wang, Yu Liang, Li Wang, Kang Qin, Faisal UL Rehman, Xiaochun Zhang,

https://doi.org/10.18632/aging.102983 pp 5878—5893

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Risk of breast cancer-related death in women with a prior cancer

Fei Ji, Ci-Qiu Yang, Xiao-Ling Li, Liu-Lu Zhang, Mei Yang, Jie-Qing Li, Hong-Fei Gao, Teng Zhu, Min-Yi Cheng, Wei-Ping Li, Si-Yan Wu, Ai-Ling Zhong, Kun Wang,

https://doi.org/10.18632/aging.102984 pp 5894—5906

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Increased intrinsic default-mode network activity as a compensatory mechanism in aMCI: a resting-state functional connectivity MRI study

Jiali Liang, Yunfei Li, Hao Liu, Sisi Zhang, Meimei Wang, Yonghua Chu, Jianping Ye, Qian Xi, Xiaohu Zhao,

https://doi.org/10.18632/aging.102986 pp 5907—5919

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Genetics of physiological dysregulation: findings from the long life family study using joint models

Konstantin G. Arbeev, Olivia Bagley, Svetlana V. Ukraintseva, Deqing Wu, Hongzhe Duan, Alexander M. Kulminski, Eric Stallard, Kaare Christensen, Joseph H. Lee, Bharat Thyagarajan, Joseph M. Zmuda, Anatoliy I. Yashin,

https://doi.org/10.18632/aging.102987 pp 5920—5947

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Overexpression of miR-10a-5p facilitates the progression of osteoarthritis

Hui-Zi Li, Xiang-He Xu, Nan Lin, Da-Wei Wang, Yi-Ming Lin, Zhong-Zhen Su, Hua-Ding Lu,

https://doi.org/10.18632/aging.102989 pp 5948—5976

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Nrf2 deficiency promotes the increasing trend of autophagy during aging in skeletal muscle: a potential mechanism for the development of sarcopenia

Dong-Dong Huang, Xia-Lin Yan, Sheng-Dong Fan, Xi-Yi Chen, Jing-Yi Yan, Qian-Tong Dong, Wei-Zhe Chen, Na-Xin Liu, Xiao-Lei Chen, Zhen Yu,

https://doi.org/10.18632/aging.102990 pp 5977—5991

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PCNA-associated factor KIAA0101 transcriptionally induced by ELK1 controls cell proliferation and apoptosis in nasopharyngeal carcinoma: an integrated bioinformatics and experimental study

Hu Zhao, Miaosheng Chen, Jie Wang, Gang Cao, Wei Chen, Jinke Xu,

https://doi.org/10.18632/aging.102991 pp 5992—6017

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Reversal of multidrug resistance in leukemia cells using a transferrin-modified nanomicelle encapsulating both doxorubicin and psoralen

He-Wen Wang, Ke-Ling Ma, Hua Liu, Jia-Yun Zhou,

https://doi.org/10.18632/aging.102992 pp 6018—6029

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Elevated p38MAPK activity promotes neural stem cell aging

Leire Moreno-Cugnon, Olatz Arrizabalaga, Irantzu Llarena, Ander Matheu,

https://doi.org/10.18632/aging.102994 pp 6030—6036

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COVID-19
Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients

Zongguo Yang, Jia Shi, Zhang He, Ying Lü, Qingnian Xu, Chen Ye, Shishi Chen, Bozong Tang, Keshan Yin, Yunfei Lu, Xiaorong Chen,

https://doi.org/10.18632/aging.102999 pp 6037—6048

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COVID-19
Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis

Bolin Wang, Ruobao Li, Zhong Lu, Yan Huang,

https://doi.org/10.18632/aging.103000 pp 6049—6057

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Aspirin alleviates hepatic fibrosis by suppressing hepatic stellate cells activation via the TLR4/NF-κB pathway

Yan Liu, Li Nong, Yuxian Jia, Aihua Tan, Lixia Duan, Yongkui Lu, Jinmin Zhao,

https://doi.org/10.18632/aging.103002 pp 6058—6066

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Identification of an exosomal long non-coding RNAs panel for predicting recurrence risk in patients with colorectal cancer

Yanli Zhang, Hui Liu, Xinfeng Liu, Yulian Guo, Yanlei Wang, Yonggang Dai, Jinhua Zhuo, Bing Wu, Hongchun Wang, Xin Zhang,

https://doi.org/10.18632/aging.103006 pp 6067—6088

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Estradiol-induced senescence of hypothalamic astrocytes contributes to aging-related reproductive function declines in female mice

Xiaoman Dai, Luyan Hong, Hui Shen, Qiang Du, Qinyong Ye, Xiaochun Chen, Jing Zhang,

https://doi.org/10.18632/aging.103008 pp 6089—6108

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Ginsenoside Rh3 activates Nrf2 signaling and protects endometrial cells from oxygen and glucose deprivation-reoxygenation

Xiu-mei Wang, Chang She, Quan Li, Di Zhang, Jin-xia Xu, Min-hui Li, Ping Li, Hong-bin Xu,

https://doi.org/10.18632/aging.103009 pp 6109—6119

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Alveolar macrophage - derived exosomes modulate severity and outcome of acute lung injury

Cong Ye, Huiting Li, Minwei Bao, Ran Zhuo, Gening Jiang, Weixi Wang,

https://doi.org/10.18632/aging.103010 pp 6120—6128

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Inhibiting Forkhead box K1 induces autophagy to reverse epithelial-mesenchymal transition and metastasis in gastric cancer by regulating Myc-associated zinc finger protein in an acidic microenvironment

Yixuan Wang, Libin Sun, Wensheng Qiu, Weiwei Qi, Yaoyue Qi, Zhao Liu, Shihai Liu, Jing Lv,

https://doi.org/10.18632/aging.103013 pp 6129—6150

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Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease

Valérie Fontaine, Elodie Monteiro, Mylène Fournié, Elena Brazhnikova, Thinhinane Boumedine, Cécile Vidal, Christine Balducci, Louis Guibout, Mathilde Latil, Pierre J. Dilda, Stanislas Veillet, José-Alain Sahel, René Lafont, Serge Camelo,

https://doi.org/10.18632/aging.103014 pp 6151—6171

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USF1-mediated upregulation of lncRNA GAS6-AS2 facilitates osteosarcoma progression through miR-934/BCAT1 axis

Guojun Wei, Tianwei Zhang, Zongguang Li, Naichun Yu, Xiang Xue, Daguo Zhou, Yongjie Chen, Linlin Zhang, Xiaoli Yao, Guangrong Ji,

https://doi.org/10.18632/aging.103015 pp 6172—6190

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Long non-coding RNA TPT1-AS1 promotes angiogenesis and metastasis of colorectal cancer through TPT1-AS1/NF90/VEGFA signaling pathway

Yiyun Zhang, Jiangyun Sun, Yuan Qi, Yimin Wang, Yu Ding, Kun Wang, Qingxin Zhou, Jingxuan Wang, Fei Ma, Jianguo Zhang, Baoliang Guo,

https://doi.org/10.18632/aging.103016 pp 6191—6205

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Application of Generalized Split Linearized Bregman Iteration algorithm for Alzheimer's disease prediction

Weimin Zheng, Bin Cui, Zeyu Sun, Xiuli Li, Xu Han, Yu Yang, Kuncheng Li, Lingjing Hu, Zhiqun Wang, Alzheimer's Disease Neuroimaging Initiative,

https://doi.org/10.18632/aging.103017 pp 6206—6224

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Rotating magnetic field ameliorates experimental autoimmune encephalomyelitis by promoting T cell peripheral accumulation and regulating the balance of Treg and Th1/Th17

Tianying Zhan, Xiaomei Wang, Zijun Ouyang, Youli Yao, Jiangyao Xu, Shikang Liu, Kan Liu, Qiyu Deng, Yushu Wang, Yingying Zhao,

https://doi.org/10.18632/aging.103018 pp 6225—6239

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Inhibition of esophageal-carcinoma cell proliferation by genistein via suppression of JAK1/2-STAT3 and AKT/MDM2/p53 signaling pathways

Jing Gao, Rongmu Xia, Jianbo Chen, Jing Gao, Xianyang Luo, Chunlin Ke, Caihong Ren, Jiayi Li, Yanjun Mi,

https://doi.org/10.18632/aging.103019 pp 6240—6259

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Myotonic dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin

Mikel García-Puga, Ander Saenz-Antoñanzas, Roberto Fernández-Torrón, Adolfo Lopez de Munain, Ander Matheu,

https://doi.org/10.18632/aging.103022 pp 6260—6275

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DNA N⁶-methyladenine modification in hypertension

Ye Guo, Yuqing Pei, Kexin Li, Wei Cui, Donghong Zhang,

https://doi.org/10.18632/aging.103023 pp 6276—6291

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Systematic analysis of bacteriostatic mechanism of flavonoids using transcriptome and its therapeutic effect on vaginitis

Zeyan Lin, Yanyan Lin, Zhengbing Zhang, Jinxing Shen, Caimei Yang, Meijiao Jiang, Youming Hou,

https://doi.org/10.18632/aging.103024 pp 6292—6305

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Bone marrow mesenchymal stem cells transplantation alleviates brain injury after intracerebral hemorrhage in mice through the Hippo signaling pathway

Xiao Chen, Can-Xin Xu, Huaibin Liang, Zhiyu Xi, Jiaji Pan, Yong Yang, Qingfang Sun, Guoyuan Yang, Yuhao Sun, Liuguan Bian,

https://doi.org/10.18632/aging.103025 pp 6306—6323

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Anterior thalamic nucleus stimulation protects hippocampal neurons by activating autophagy in epileptic monkeys

Ting-Ting Du, Guanyu Zhu, Yingchuan Chen, Lin Shi, Defeng Liu, Yuye Liu, Xin Zhang, Jianguo Zhang,

https://doi.org/10.18632/aging.103026 pp 6324—6339

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Leptin acts on mesenchymal stem cells to promote chemoresistance in osteosarcoma cells

Helin Feng, Qianqian Zhang, Yi Zhao, Lili Zhao, Baoen Shan,

https://doi.org/10.18632/aging.103027 pp 6340—6351

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FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer

Libin Ma, Huadong He, Kang Jiang, Peiwu Jiang, Han He, Shengjia Feng, Kean Chen, Jia Shao, Gang Deng,

https://doi.org/10.18632/aging.103030 pp 6352—6369

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NO up-regulates migraine-related CGRP via activation of an Akt/GSK-3β/NF-κB signaling cascade in trigeminal ganglion neurons

Gang Yao, Yu-Hong Man, An-Ran Li, Yu Guo, Yun Dai, Ping Wang, Yi-Fa Zhou,

https://doi.org/10.18632/aging.103031 pp 6370—6384

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Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis

Weihua Bian, Xiaohong Jing, Zhiyu Yang, Zhen Shi, Ruiyao Chen, Aili Xu, Na Wang, Jing Jiang, Cheng Yang, Daolai Zhang, Lan Li, Haiyan Wang, Juan Wang, Yeying Sun, Chunxiang Zhang,

https://doi.org/10.18632/aging.103034 pp 6385—6400

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Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

Ting-Ting Xu, Han Li, Zhao Dai, George K. Lau, Ben-Yue Li, Wen-Li Zhu, Xiao-Qi Liu, Hao-Fei Liu, Wei-Wu Cai, Shui-Qing Huang, Qi Wang, Shi-Jie Zhang,

https://doi.org/10.18632/aging.103035 pp 6401—6414

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Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation

Lin Cong, Ziyu Gao, Yinghong Zheng, Ting Ye, Zitong Wang, Pengyu Wang, Manman Li, Bowen Dong, Wei Yang, Quanfeng Li, Shupei Qiao, Cao Wang, Yijun Shen, Hong Li, Weiming Tian, Liming Yang,

https://doi.org/10.18632/aging.103038 pp 6415—6435

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Sevoflurane inhibits neuronal migration and axon growth in the developing mouse cerebral cortex

Dongdong Chai, Jia Yan, Chunzhu Li, Yu Sun, Hong Jiang,

https://doi.org/10.18632/aging.103041 pp 6436—6455

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FGF22 promotes generation of ribbon synapses through downregulating MEF2D

Shuna Li, Jingchun He, Yupeng Liu, Jun Yang,

https://doi.org/10.18632/aging.103042 pp 6456—6466

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Role of mitochondrial quality control in the pathogenesis of nonalcoholic fatty liver disease

Ruibing Li, Sam Toan, Hao Zhou,

https://doi.org/10.18632/aging.102972 pp 6467—6485

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Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

Lan Ye, Anne L. Widlund, Carrie A. Sims, Dudley W. Lamming, Yuxia Guan, James G. Davis, David M. Sabatini, David E. Harrison, Ole Vang, Joseph A. Baur,

https://doi.org/10.18632/aging.102976 pp 6486—6487

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Correction for: Lycorine induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer

Man Hu, Zhaomin Yu, Peiyuan Mei, Jinxiao Li, Dan Luo, Haiming Zhang, Minfeng Zhou, Fengxia Liang, Rui Chen,

https://doi.org/10.18632/aging.103011 pp 6488—6489

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Featured Nobel Articles

Volume 12, Issue 7

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Editorial

Iris Oving, Marieke T. Blom, Hanno L. Tan,

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Jingjing Zhao, Gen Li, Xuan Zhao, Xin Lin, Yunge Gao, Nuno Raimundo, Geng-Lin Li, Wei Shang, Hao Wu, Lei Song,

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Eliene Albers, Alexandra Avram, Mauro Sbroggio, Oscar Fernandez-Capetillo, Andres J. Lopez-Contreras,

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Rongyang Li, Bojiang Li, Ming Shen, Yan Cao, Xuan Zhang, Weijian Li, Jingli Tao, Wangjun Wu, Honglin Liu,

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Ye Zhang, Xinxin Liu, Junying Zhang, Yuanyuan Xu, Jie Shao, Yue Hu, Peng Shu, Haibo Cheng,

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Yao Chen, Lin-Shuang Zhang, Jin-Ling Ren, Ya-Rong Zhang, Ning Wu, Mo-Zhi Jia, Yan-Rong Yu, Zhong-Ping Ning, Chao-Shu Tang, Yong-Fen Qi,

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Cheng Tan, Yimeng Dai, Xiaoyang Liu, Guifang Zhao, Weiyao Wang, Jia Li, Ling Qi,

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Mahmoud Al-Azab, Bing Wang, Abdalkhalig Elkhider, Williams Walana, Weiping Li, Bo Yuan, Yunshan Ye, Yawei Tang, Marwan Almoiliqy, Salah Adlat, Jing Wei, Yan Zhang, Xia Li,

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Xi Chen, Chiyao Wang, Pei Yang, Lei Shi, Haiyan Wang,

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Jingtai Zhi, Jiaoyu Yi, Mengran Tian, Huijuan Wang, Ning Kang, Xiangqian Zheng, Ming Gao,

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Mingsheng Cai, Xiaowen Ou, Yiwen Li, Xingmei Zou, Zuo Xu, Yuanfang Wang, Hao Peng, Yangxi Deng, Yingjie Guo, Manjiao Lu, Weidong Gan, Tao Peng, Meili Li,

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Yu-Chen Lin, Mei-Chuan Chen, Tsung-Han Hsieh, Jing-Ping Liou, Chun-Han Chen,

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Jiong Yu, Xiaowei Shi, Chunzhang Yang, Petra Bullova, Christopher S. Hong, Cody L. Nesvick, Pauline Dmitriev, Karel Pacak, Zhengping Zhuang, Hongcui Cao, Lanjuan Li,

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Ming Hong, Han Zhu, Qian Sun, Yu Zhu, Yi Miao, Hui Yang, Hai-Rong Qiu, Jian-Yong Li, Si-Xuan Qian,

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Qiqing Huang, Yan Chen, Shaoran Shen, Yuanyuan Wang, Liya Liu, Shuangshuang Wu, Wei Xu, Weihong Zhao, Mingyan Lin, Jianqing Wu,

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Kang Lin, Jun Huang, Hongliang Luo, Chen Luo, Xiaojian Zhu, Fanqin Bu, Han Xiao, Li Xiao, Zhengming Zhu,

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Mengqing Ma, Xin Wan, Min Gao, Binbin Pan, Dawei Chen, Qing Sun, Mengyu Zhang, Changgao Zhou, Tao Li, Hanchao Pan, Wei Shao, Zhihe Liu, Yue Chen, Changchun Cao,

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Deze Zhao, Chuantao Zhang, Man Jiang, Yongjie Wang, Yu Liang, Li Wang, Kang Qin, Faisal UL Rehman, Xiaochun Zhang,

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Fei Ji, Ci-Qiu Yang, Xiao-Ling Li, Liu-Lu Zhang, Mei Yang, Jie-Qing Li, Hong-Fei Gao, Teng Zhu, Min-Yi Cheng, Wei-Ping Li, Si-Yan Wu, Ai-Ling Zhong, Kun Wang,

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COVID-19
Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients

COVID-19
Does comorbidity increase the risk of patients with COVID-19: evidence from meta-analysis