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The cover features Figure 1 "The metabolomic study of sarcopenia" from Kameda et al.

Volume 13, Issue 17

15 September, 2021
pp 20854—21807

About the Cover

The cover features Figure 1 "The metabolomic study of sarcopenia" from Kameda et al.


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Editorials

Aging, stem cells and cancer updated

Osama A. Elkashty, Arvind Hariharan, Simon D. Tran,
https://doi.org/10.18632/aging.203535 pp 20854—20855
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CX3CR1 and malignant progression of glioma

Sungho Lee, Benjamin Deneen, Ganesh Rao,
https://doi.org/10.18632/aging.203536 pp 20856—20857
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Regulation of p73 by Pirh2-AIP4 loop

H. Helena Wu, Rami Abou Zeinab, Roger P. Leng,
https://doi.org/10.18632/aging.203537 pp 20858—20859
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Research Papers

COVID-19
Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients

Mélanie Bourgin, Lisa Derosa, Carolina Alves Costa Silva, Anne-Gaëlle Goubet, Agathe Dubuisson, François-Xavier Danlos, Claudia Grajeda-Iglesias, Luigi Cerbone, Arthur Geraud, Ariane Laparra, Fanny Aprahamian, Nitharsshini Nirmalathasan, Frank Madeo, Laurence Zitvogel, Guido Kroemer, Sylvère Durand,
https://doi.org/10.18632/aging.203525 pp 20860—20885
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COVID-19
The potential role of abnormal angiotensin-converting enzyme 2 expression correlated with immune infiltration after SARS-CoV-2 infection in the prognosis of breast cancer

Yufeng Jiang, Ling Chen, Jinsheng Shen, Xiaofei Mei, Jialu Yao, Tan Chen, Yafeng Zhou,
https://doi.org/10.18632/aging.203418 pp 20886—20895
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COVID-19
Prognostic value of neutrophil-to-lymphocyte ratio, lactate dehydrogenase, D-dimer, and computed tomography score in patients with coronavirus disease 2019

Yu-Qing Cai, Xiao-Bin Zhang, Hui-Qing Zeng, Xiao-Jie Wei, Lan Hu, Zhen-Yu Zhang, Quan Ming, Qiu-Ping Peng, Li-Da Chen,
https://doi.org/10.18632/aging.203501 pp 20896—20905
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COVID-19
High-dose vitamin C ameliorates cardiac injury in COVID-19 pandemic: a retrospective cohort study

Guozhi Xia, Bowen Qin, Chaoran Ma, Yaowu Zhu, Qiangsun Zheng,
https://doi.org/10.18632/aging.203503 pp 20906—20914
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Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty

Masahiro Kameda, Takayuki Teruya, Mitsuhiro Yanagida, Hiroshi Kondoh,
https://doi.org/10.18632/aging.203498 pp 20915—20934
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Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients

Ronit Shapira, Amos Gdalyahu, Irit Gottfried, Efrat Sasson, Amir Hadanny, Shai Efrati, Pablo Blinder, Uri Ashery,
https://doi.org/10.18632/aging.203485 pp 20935—20961
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Glutamine promotes escape from therapy-induced senescence in tumor cells

Francesco Pacifico, Nadia Badolati, Stefano Mellone, Mariano Stornaiuolo, Antonio Leonardi, Elvira Crescenzi,
https://doi.org/10.18632/aging.203495 pp 20962—20991
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Transcriptomic analysis of elderly women with low muscle mass: association with immune system pathway

Levi H. Jales Neto, Bidossessi W. Hounkpe, Georgea H. Fernandes, Liliam Takayama, Valéria F. Caparbo, Neuza H.M. Lopes, Alexandre C. Pereira, Rosa M.R. Pereira,
https://doi.org/10.18632/aging.203505 pp 20992—21008
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Glutathione is an aging-related metabolic signature in the mouse kidney

Eunyong Ahn, Jueun Lee, Jisu Han, Seung-Min Lee, Ki-Sun Kwon, Geum-Sook Hwang,
https://doi.org/10.18632/aging.203509 pp 21009—21028
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Familial longevity is associated with lower baseline bone turnover but not differences in bone turnover in response to rhTSH

Ana Zutinic, Ferdinand Roelfsema, Hanno Pijl, Bart E. Ballieux, Rudi G.J. Westendorp, Gerard J. Blauw, Diana van Heemst,
https://doi.org/10.18632/aging.203511 pp 21029—21039
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Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans

Ioan Valentin Matei, Vimbai Netsai Charity Samukange, Gabriela Bunu, Dmitri Toren, Simona Ghenea, Robi Tacutu,
https://doi.org/10.18632/aging.203518 pp 21040—21065
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Sex-specific differences in DNA double-strand break repair of cycling human lymphocytes during aging

Melanie Rall-Scharpf, Thomas W.P. Friedl, Shahar Biechonski, Michael Denkinger, Michael Milyavsky, Lisa Wiesmüller,
https://doi.org/10.18632/aging.203519 pp 21066—21089
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Effect of the Notch1-mediated PI3K-Akt-mTOR pathway in human osteosarcoma

Kexiang Zhang, Song Wu, Hongwei Wu, Li Liu, Jiahui Zhou,
https://doi.org/10.18632/aging.203261 pp 21090—21101
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Bortezomib enhances the anti-cancer effect of the novel Bruton’s tyrosine kinase inhibitor (BGB-3111) in mantle cell lymphoma expressing BTK

Xianhuo Wang, Yue Fei, Xia Liu, Tingting Zhang, Wei Li, Xiaohui Jia, Xianming Liu, Lihua Qiu, Zhengzi Qian, Shiyong Zhou, Xiubao Ren, Qiongli Zhai, Bin Meng, Lanfang Li, Huilai Zhang,
https://doi.org/10.18632/aging.203314 pp 21102—21121
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Circular RNA ZNF609 enhances proliferation and glycolysis during glioma progression by miR-378b/SLC2A1 axis

Zhihuang Zhao, Gang Li, Yonggang Han, Yabin Li, Zhisheng Ji, Rui Guo, Xiaohong Yu,
https://doi.org/10.18632/aging.203331 pp 21122—21133
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RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation

Jing Wang, Qiang Fu, Jian Yang, Jin-Long Liu, Shu-Ming Hou, Xing Huang, Jia-Shi Cao, Tie-Long Liu, Kun-Zheng Wang,
https://doi.org/10.18632/aging.203377 pp 21134—21141
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Serglycin promotes proliferation, migration, and invasion via the JAK/STAT signaling pathway in osteosarcoma

Bin Lv, Guangyu Gao, Yuhong Guo, Zhiping Zhang, Renfeng Liu, Zhengzai Dai, Cheng Ju, Yiping Liang, Xiaofeng Tang, Min Tang, Xiao-Bin Lv,
https://doi.org/10.18632/aging.203392 pp 21142—21154
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Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways

Yu Liu, Yan-Qing Li, Shi-Hao Huang, Yong-Long Li, Jia-Wei Xia, Jun-Shuang Jia, Fang Wei, Jia-Hong Wang, Guan-Qi Dai, Yu-Cai Wang, Xiao-Yan Li, Liu-Xin Han, Xiao-Ling Zhang, Xu-Dong Xiang, Wen-Tao Zhao, Dong Xiao, Xiao-Lin Lin,
https://doi.org/10.18632/aging.203402 pp 21155—21190
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LncRNA PITPNA-AS1 promotes gastric cancer by increasing SOX4 expression via inhibition of miR-92a-3p

Licheng Liu, Anna Dai, Zao Zhang, Meiying Ning, Dong Han, Li Li, Zhuangzhuang Li,
https://doi.org/10.18632/aging.203403 pp 21191—21201
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UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma

Minfen Zhang, Hui Chen, Ping Qin, Tonghui Cai, Lingjun Li, Ruichao Chen, Shaoyan Liu, Hui Chen, Wanrun Lin, Hao Chen, Amanda L. Strickland, Hanzhen Xiong, Qingping Jiang,
https://doi.org/10.18632/aging.203421 pp 21202—21215
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Dual roles of WISP2 in the progression of hepatocellular carcinoma: implications of the fibroblast infiltration into the tumor microenvironment

Qingan Jia, Yaoyao Zhang, Binghui Xu, Xia Liao, Yang Bu, Zihan Xu, Xianglong Duan, Qiangbo Zhang,
https://doi.org/10.18632/aging.203424 pp 21216—21231
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LncRNA SNHG17 promotes tumor progression and predicts poor survival in human renal cell carcinoma via sponging miR-328-3p

Jie Wu, Gang Dong, Tingting Liu, Shaojin Zhang, Lulu Sun, Weijie Liang,
https://doi.org/10.18632/aging.203440 pp 21232—21250
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Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells

Yan Zhang, Ning He, Xuejian Zhou, Feifan Wang, Hairong Cai, Shih Han Huang, Xianwu Chen, Zhenghui Hu, Xiaodong Jin,
https://doi.org/10.18632/aging.203441 pp 21251—21267
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Celecoxib reverses the glioblastoma chemo-resistance to temozolomide through mitochondrial metabolism

Delong Yin, Guoqing Jin, Hong He, Wei Zhou, Zhenbo Fan, Chen Gong, Jing Zhao, Huihua Xiong,
https://doi.org/10.18632/aging.203443 pp 21268—21282
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RUFY3 promotes the progression of hepatocellular carcinoma through activating NF-κB-mediated epithelial-mesenchymal transition

Yang Zhang, Weixing Ni, Lei Qin,
https://doi.org/10.18632/aging.203444 pp 21283—21293
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PPM1D is a potential prognostic biomarker and correlates with immune cell infiltration in hepatocellular carcinoma

Zhangtao Yu, Yinghui Song, Mengting Cai, Bo Jiang, Zhihua Zhang, Le Wang, Yu Jiang, Lianhong Zou, Xiehong Liu, Nanhui Yu, Xianhai Mao, Chuang Peng, Sulai Liu,
https://doi.org/10.18632/aging.203459 pp 21294—21308
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Activation of the gut microbiota-kynurenine-liver axis contributes to the development of nonalcoholic hepatic steatosis in nondiabetic adults

Guoyuan Sui, Lianqun Jia, Dongmei Quan, Na Zhao, Guanlin Yang,
https://doi.org/10.18632/aging.203460 pp 21309—21324
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Knockdown of PSMC2 contributes to suppression of cholangiocarcinoma development by regulating CDK1

Xiaohui Duan, Jianhui Yang, Bo Jiang, Wenbin Duan, Rongguang Wei, Hui Zhang, Xianhai Mao,
https://doi.org/10.18632/aging.203463 pp 21325—21344
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Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-κB axis

Li Cai, Beihai Ge, Shengbo Xu, Xiangwen Chen, Hong Yang,
https://doi.org/10.18632/aging.203468 pp 21345—21363
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Deferoxamine accelerates endothelial progenitor cell senescence and compromises angiogenesis

Yi-Nan Lee, Hsueh-Hsiao Wang, Cheng-Huang Su, Hsin-I Lee, Yen-Hung Chou, Chin-Ling Hsieh, Wen-Ting Liu, Kuo-Tung Shu, Kai-Ting Chang, Hung-I Yeh, Yih-Jer Wu,
https://doi.org/10.18632/aging.203469 pp 21364—21384
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Identification and validation of a ferroptosis-related gene signature predictive of prognosis in breast cancer

Qin Liu, Jian-Ying Ma, Gaosong Wu,
https://doi.org/10.18632/aging.203472 pp 21385—21399
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Baseline beliefs about medication are associated with outcomes of antidepressants in inpatients with first-diagnosed depression under supervised therapeutic compliance

Fan-Zhen Kong, Cai-Fang Ji, Xiang-Dong Du, Robert Logan, Hui-Ying Zhao, Guan-Hui Wu, Yan-Song Liu, Zhen Tang, Mei-E Niu,
https://doi.org/10.18632/aging.203477 pp 21400—21407
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Blood transfusion practices affect CD4+ CD25+ FOXP3+ regulatory T cells/T helper-17 cells and the clinical outcome of geriatric patients with hip fracture

Ling Wang, Wei Chen, Fu-Biao Kang, Ya-Hui Zhang, Li-Li Qi, Ying-Ze Zhang,
https://doi.org/10.18632/aging.203479 pp 21408—21420
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Low lean mass is associated with lower urinary tract symptoms in US men from the 2005–2006 national health and nutrition examination survey dataset

Zheng Qin, Junjie Zhao, Jiameng Li, Qinbo Yang, Jiwen Geng, Ruoxi Liao, Baihai Su,
https://doi.org/10.18632/aging.203480 pp 21421—21434
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MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells

Hongqing Wen, Zhiyan Liu, Jingjing Tang, Lina Bu,
https://doi.org/10.18632/aging.203483 pp 21435—21450
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Identification and epidemiological evaluation of gastric cancer risk factors: based on a field synopsis and meta-analysis in Chinese population

Fujiao Duan, Chunhua Song, Jiachen Shi, Peng Wang, Hua Ye, Liping Dai, Jianying Zhang, Kaijuan Wang,
https://doi.org/10.18632/aging.203484 pp 21451—21469
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SCFAs promote intestinal double-negative T cells to regulate the inflammatory response mediated by NLRP3 inflammasome

Shuiliang Ruan, Liping Zhai, Shasha Wu, Caiqun Zhang, Qiaobing Guan,
https://doi.org/10.18632/aging.203487 pp 21470—21482
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2,5-dimethyl celecoxib induces apoptosis and autophagy via activation of ROS/JNK axis in nasopharyngeal carcinoma cells

Tan Tan, Xiangjie Fu, Jiaquan Qu, Miao Zhang, He Chen, Yaochun Wang, Bo Wang, Juan Li, Jie Liu, Peijun Liu,
https://doi.org/10.18632/aging.203488 pp 21483—21496
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m6A demethylase ALKBH5 suppression contributes to esophageal squamous cell carcinoma progression

Dong Xiao, Ting-Xiao Fang, Ye Lei, Sheng-Jun Xiao, Jia-Wei Xia, Tao-Yan Lin, Yong-Long Li, Jian-Xue Zhai, Xiao-Yan Li, Shi-Hao Huang, Jun-Shuang Jia, Yu-Guang Tian, Xiao-Lin Lin, Kai-Can Cai, Yan Sun,
https://doi.org/10.18632/aging.203490 pp 21497—21512
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Converting health risks into loss of life years - a paradigm shift in clinical risk communication

Shan Pou Tsai, Chi Pang Wen, Min Kuang Tsai, Po Jung Lu, Jackson Pui Man Wai, Christopher Wen, Wayne Gao, Xifeng Wu,
https://doi.org/10.18632/aging.203491 pp 21513—21525
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Calorie intake rather than food quantity consumed is the key factor for the anti-aging effect of calorie restriction

Yaru Liang, Yuqi Gao, Rui Hua, Maoyang Lu, Huiling Chen, Zhuoran Wang, Liyuan Li, Kaiqiang Hu, Yuemiao Yin, Kang Xu, Hongqi Gao, Qingfei Liu, Ying Qiu, Zhao Wang,
https://doi.org/10.18632/aging.203493 pp 21526—21546
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HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells

Dan-Dan Chen, Xuyan Peng, Yuxuan Wang, Mingjun Jiang, Mengjiao Xue, Guohui Shang, Xuhui Liu, Xiaolin Jia, Baixue Liu, Yingwei Lu, Hongmei Mu, Fengyan Zhang, Yanzhong Hu,
https://doi.org/10.18632/aging.203496 pp 21547—21570
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TNFSF9 promotes metastasis of pancreatic cancer through Wnt/Snail signaling and M2 polarization of macrophages

Jiao Wu, Yunpeng Wang, Yichun Yang, Fuqiang Liu, Jun Chen, Zhongxiang Jiang, Zheng Jiang,
https://doi.org/10.18632/aging.203497 pp 21571—21586
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FOXN3 inhibits cell proliferation and invasion via modulating the AKT/MDM2/p53 axis in human glioma

Chaojia Wang, Hanjun Tu, Ling Yang, Chunming Ma, Juntao Hu, Jie Luo, Hui Wang,
https://doi.org/10.18632/aging.203499 pp 21587—21598
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Association between tooth loss rate and risk of mild cognitive impairment in older adults: a population-based longitudinal study

Shuyu Xu, Xi Huang, Yin Gong, Jiangwei Sun,
https://doi.org/10.18632/aging.203504 pp 21599—21609
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Genome-wide identification of altered RNA m6A profiles in vascular tissue of septic rats

Zhu-Jun Shen, Ye-Chen Han, Mu-Wen Nie, Yi-Ning Wang, Ruo-Lan Xiang, Hong-Zhi Xie,
https://doi.org/10.18632/aging.203506 pp 21610—21627
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Development and validation of a clinical model (DREAM-LDL) for post-stroke cognitive impairment at 6 months

Yi Dong, Mengyuan Ding, Mei Cui, Min Fang, Li Gong, Zhuojun Xu, Yue Zhang, Xiuzhe Wang, Xiaofeng Xu, Xueyuan Liu, Gang Li, Yuwu Zhao, Qiang Dong,
https://doi.org/10.18632/aging.203507 pp 21628—21641
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Astrocyte-derived exosomes protect hippocampal neurons after traumatic brain injury by suppressing mitochondrial oxidative stress and apoptosis

Wenqian Zhang, Jun Hong, Hanwen Zhang, Wencheng Zheng, Ying Yang,
https://doi.org/10.18632/aging.203508 pp 21642—21658
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Alternation of brain intrinsic activity in patients with hypertensive retinopathy: a resting-state fMRI study

Jin-Yu Hu, Hui-Ye Shu, Qiu-Yu Li, Shi-Nan Wu, Rong-Bin Liang, Qian-Min Ge, Li-Juan Zhang, Yi-Cong Pan, Yi Shao,
https://doi.org/10.18632/aging.203510 pp 21659—21670
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Integrated analysis identifies TfR1 as a prognostic biomarker which correlates with immune infiltration in breast cancer

Fei Chen, Yumei Fan, Jiajie Hou, Bing Liu, Bo Zhang, Yanan Shang, Yanzhong Chang, Pengxiu Cao, Ke Tan,
https://doi.org/10.18632/aging.203512 pp 21671—21699
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Effect of different exercise training intensities on age-related cardiac damage in male mice

Zuowei Pei, Chenguang Yang, Ying Guo, Min Dong, Fang Wang,
https://doi.org/10.18632/aging.203513 pp 21700—21711
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The ceRNA PVT1 inhibits proliferation of ccRCC cells by sponging miR-328-3p to elevate FAM193B expression

Guohai Xie, Xinyi Zheng, Zhong Zheng, Ruoyu Wu, Zhixian Yao, Wenjie Huang, Feng Sun, Xingyu Mu, Ke Wu, Junhua Zheng,
https://doi.org/10.18632/aging.203514 pp 21712—21728
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Cytokine antibody array-based analysis of IL-37 treatment effects in asthma

Shengnan Gao, Jingru Wang, Qing Zhang, Jun Shu, Chunxiao Li, Hongwen Li, Jiangtao Lin,
https://doi.org/10.18632/aging.203515 pp 21729—21742
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lncRNA HCG11 suppresses human osteosarcoma growth through upregulating p27 Kip1

Jie Gu, Bo Dai, Xuchao Shi, Zhennian He, Yuanlin Xu, Xiangqian Meng, Junlan Zhu,
https://doi.org/10.18632/aging.203517 pp 21743—21757
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The upregulated expression of RFC4 and GMPS mediated by DNA copy number alteration is associated with the early diagnosis and immune escape of ESCC based on a bioinformatic analysis

Jing Wang, Fei-Fei Luo, Tie-Jun Huang, Yan Mei, Li-Xia Peng, Chao-Nan Qian, Bi-Jun Huang,
https://doi.org/10.18632/aging.203520 pp 21758—21777
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Transfection of STAT3 overexpression plasmid mediated through recombinant lentivirus promotes differentiation of bone marrow mesenchymal stem cells into neural cells in fetal rats with spina bifida aperta

Mingyu Jiang, Jiale Feng, Rong Fu, Yanbo Pan, Xu Liu, Jicheng Dai, Chunming Jiang, Yunpeng Hao, Mingyong Ren,
https://doi.org/10.18632/aging.203524 pp 21778—21790
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Review

Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer’s disease: an adrenergic approach

Song Li, Che Wang, Zhen Wang, Jun Tan,
https://doi.org/10.18632/aging.203482 pp 21791—21806
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Retraction

Retraction: Downregulation of microRNA-218 is cardioprotective against cardiac fibrosis and cardiac function impairment in myocardial infarction by binding to MITF

Linfeng Qian, Shaobo Pan, Liping Shi, Yongyi Zhou, Lai Sun, Zhedong Wan, Yufang Ding, Jia Qian,
https://doi.org/10.18632/aging.203548 pp 21807
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