The cover features Figure 4 "Using age predictors within specified age groups to infer causality and identify therapeutic interventions" from Zhavoronkov et al.
Daniela Bakula, Andrea Ablasser, Adriano Aguzzi, Adam Antebi, Nir Barzilai, Martin-Immanuel Bittner, Martin Borch Jensen, Cornelis F. Calkhoven, Danica Chen, Aubrey D.N.J. de Grey, Jerome N. Feige, Anastasia Georgievskaya, Vadim N. Gladyshev, Tyler Golato, Andrei V. Gudkov, Thorsten Hoppe, Matt Kaeberlein, Pekka Katajisto, Brian K. Kennedy, Unmesh Lal, Ana Martin-Villalba, Alexey A. Moskalev, Ivan Ozerov, Michael A. Petr, Reason, David C. Rubinsztein, Alexander Tyshkovskiy, Quentin Vanhaelen, Alex Zhavoronkov, Morten Scheibye-Knudsen,
Bakula D, Ablasser A, Aguzzi A, Antebi A, Barzilai N, Bittner M, Jensen MB, Calkhoven CF, Chen D, Grey ADd, Feige JN, Georgievskaya A, Gladyshev VN, et al, . Latest advances in aging research and drug discovery. . 11:9971-9981. https://doi.org/10.18632/aging.102487
Tang Q, Chen Z, Zhao L, Xu H, . Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1. . 11:9982-9999. https://doi.org/10.18632/aging.102356
Sun P, Lou W, Liu J, Shi L, Li K, Wang D, Mok VC, Liang P, . Mapping the patterns of cortical thickness in single- and multiple-domain amnestic mild cognitive impairment patients: a pilot study. . 11:10000-10015. https://doi.org/10.18632/aging.102362
Yang Y, Tang F, Wei F, Yang L, Kuang C, Zhang H, Deng J, Wu Q, . Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice. . 11:10016-10030. https://doi.org/10.18632/aging.102388
Wu X, Chen W, Lin F, Huang Q, Zhong J, Gao H, Song Y, Liang H, . DNA methylation profile is a quantitative measure of biological aging in children. . 11:10031-10051. https://doi.org/10.18632/aging.102399
Xu C, Liu Y, Jiang D, Ge X, Huang J, Su J, Zhang X, Lu S, Ji Y, Hou J, Liu T, Hou Y, . Late stage gastric cancer patients with extra gained HER2 positivity by dual block assessment may not show compromised efficacy to trastuzumab treatment. . 11:10052-10060. https://doi.org/10.18632/aging.102415
Liu H, Sun Y, Tian H, Xiao X, Zhang J, Wang Y, Yu F, . Characterization of long non-coding RNA and messenger RNA profiles in laryngeal cancer by weighted gene co-expression network analysis. . 11:10074-10099. https://doi.org/10.18632/aging.102419
Huang R, Meng T, Chen R, Yan P, Zhang J, Hu P, Zhu X, Yin H, Song D, Huang Z, . The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma. . 11:10116-10143. https://doi.org/10.18632/aging.102424
Zhou W, Gong J, Chen Y, Chen J, Zhuang Q, Cao J, Mei Z, Hu B, . Long noncoding RNA LINC00899 suppresses breast cancer progression by inhibiting miR-425. . 11:10144-10153. https://doi.org/10.18632/aging.102426
Pan X, Lu Y, Huang J, Long Y, Yao D, . Prognostic genes in the tumor microenvironment in cervical squamous cell carcinoma. . 11:10154-10166. https://doi.org/10.18632/aging.102429
Yang E, Cai Y, Yao X, Liu J, Wang Q, Jin W, Wu Q, Fan W, Qiu L, Kang C, Wu J, . Tissue plasminogen activator disrupts the blood-brain barrier through increasing the inflammatory response mediated by pericytes after cerebral ischemia. . 11:10167-10182. https://doi.org/10.18632/aging.102431
Zhang C, He H, Hu X, Liu A, Huang D, Xu Y, Chen L, Xu D, . Development and validation of a metastasis-associated prognostic signature based on single-cell RNA-seq in clear cell renal cell carcinoma. . 11:10183-10202. https://doi.org/10.18632/aging.102434
Lu G, Lai Y, Wang T, Lin W, Lu J, Ma Y, Chen Y, Ma H, Liu R, Li J, . Mitochondrial fission regulator 2 (MTFR2) promotes growth, migration, invasion and tumour progression in breast cancer cells. . 11:10203-10219. https://doi.org/10.18632/aging.102442
Han Y, Yuan F, Deng C, He F, Zhang Y, Shen H, Chen Z, Qian L, . Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release. . 11:10252-10265. https://doi.org/10.18632/aging.102453
Gu N, Wang X, Di Z, Xiong J, Ma Y, Yan Y, Qian Y, Zhang Q, Yu J, . Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis. . 11:10266-10283. https://doi.org/10.18632/aging.102455
Zhang X, Wang Y, Li X, Yang A, Li Z, Wang D, . The anti-carcinogenesis properties of erianin in the modulation of oxidative stress-mediated apoptosis and immune response in liver cancer. . 11:10284-10300. https://doi.org/10.18632/aging.102456
Lv Y, Ji M, Feng Q, Zhu D, Lin S, Mao Y, Xu Y, Zheng P, He G, Xu J, . Combined test of third lumbar skeletal muscle index and prognostic nutrition index improve prognosis prediction power in resected colorectal cancer liver metastasis. . 11:10301-10315. https://doi.org/10.18632/aging.102457
Song J, Song F, Liu K, Zhang W, Luo R, Tang Y, Ran L, . Multi-omics analysis reveals epithelial-mesenchymal transition-related gene FOXM1 as a novel prognostic biomarker in clear cell renal carcinoma. . 11:10316-10337. https://doi.org/10.18632/aging.102459
Constanza Morén, Diana Luz Juárez-Flores, Kai-Yin Chau, Matthew Gegg, Glòria Garrabou, Ingrid González-Casacuberta, Mariona Guitart-Mampel, Eduardo Tolosa, María José Martí, Francesc Cardellach, Anthony Henry Vernon Schapira,
Morén C, Juárez-Flores DL, Chau K, Gegg M, Garrabou G, González-Casacuberta I, Guitart-Mampel M, Tolosa E, Martí MJ, Cardellach F, Schapira AHV, . GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models. . 11:10338-10355. https://doi.org/10.18632/aging.102460
Lv X, Wang X, Wang Y, Zhou D, Li W, Wilson JX, Chang H, Huang G, . Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a
potential mechanism. . 11:10356-10373. https://doi.org/10.18632/aging.102461
Xu J, Liu K, Chen T, Zhan T, Ouyang Z, Wang Y, Liu W, Zhang X, Sun Y, Xu G, Wang X, . Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans. . 11:10385-10408. https://doi.org/10.18632/aging.102466
Chen J, Liu J, Lei Y, Liu M, . The anti-inflammation, anti-oxidative and anti-fibrosis properties of swertiamarin in cigarette smoke exposure-induced prostate dysfunction in rats. . 11:10409-10421. https://doi.org/10.18632/aging.102467
Song M, Zhong A, Yang J, He J, Cheng S, Zeng J, Huang Y, Pan Q, Zhao J, Zhou Z, Zhu Q, Tang Y, Chen H, et al, . Large-scale analyses identify a cluster of novel long noncoding RNAs as potential competitive endogenous RNAs in progression of hepatocellular carcinoma. . 11:10422-10453. https://doi.org/10.18632/aging.102468
Yu F, Han W, Zhan G, Li S, Jiang X, Wang L, Xiang S, Zhu B, Yang L, Luo A, Hua F, Yang C, . Abnormal gut microbiota composition contributes to the development of type 2 diabetes mellitus in db/db mice. . 11:10454-10467. https://doi.org/10.18632/aging.102469
Guo Y, Xu W, Li J, Ou Y, Shen X, Huang Y, Dong Q, Tan L, Yu J, . Genome-wide association study of hippocampal atrophy rate in non-demented elders. . 11:10468-10484. https://doi.org/10.18632/aging.102470
Zhang Y, He F, Chen Z, Su Q, Yan M, Zhang Q, Tan J, Qian L, Han Y, . Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation. . 11:10499-10512. https://doi.org/10.18632/aging.102472
Sun K, Luo J, Jing X, Guo J, Yao X, Hao X, Ye Y, Liang S, Lin J, Wang G, Guo F, . Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis. . 11:10513-10531. https://doi.org/10.18632/aging.102474
Marcozzi S, Rossi V, Salvatore G, Di Rella F, De Felici M, Klinger FG, . Distinct effects of epirubicin, cisplatin and cyclophosphamide on ovarian somatic cells of prepuberal ovaries. . 11:10532-10556. https://doi.org/10.18632/aging.102476
Huang S, Zhang B, Fan W, Zhao Q, Yang L, Xin W, Fu D, . Identification of prognostic genes in the acute myeloid leukemia microenvironment. . 11:10557-10580. https://doi.org/10.18632/aging.102477
Gyanwali B, Shaik MA, Tan CS, Vrooman H, Venketasubramanian N, Chen C, Hilal S, . Mixed-location cerebral microbleeds as a biomarker of neurodegeneration in a memory clinic population. . 11:10581-10596. https://doi.org/10.18632/aging.102478
Zhao L, Li C, Zhou B, Luo C, Wang Y, Che L, Zhao J, Xu Y, . Crucial role of serum response factor in renal tubular epithelial cell epithelial-mesenchymal transition in hyperuricemic nephropathy. . 11:10597-10609. https://doi.org/10.18632/aging.102479
Ma X, Jiang Z, Li N, Jiang W, Gao P, Yang M, Yu X, Wang G, Zhang Y, . Ets2 suppresses inflammatory cytokines through MAPK/NF-κB signaling and directly binds to the IL-6 promoter in macrophages. . 11:10610-10625. https://doi.org/10.18632/aging.102480
Li M, Liu Y, Liu J, Li W, Li N, Xue D, Zhang X, Wang P, . Circ_0006332 promotes growth and progression of bladder cancer by modulating MYBL2 expression via miR-143. . 11:10626-10643. https://doi.org/10.18632/aging.102481
Sun J, Hu X, Gao Y, Tang Q, Zhao Z, Xi W, Yang F, Zhang W, Song Y, Song B, Wang T, Wang H, . MYSM1-AR complex-mediated repression of Akt/c-Raf/GSK-3β signaling impedes castration-resistant prostate cancer growth. . 11:10644-10663. https://doi.org/10.18632/aging.102482
Liu S, Huang J, Zhang Y, Liu Y, Zuo S, Li R, . MAP2K4 interacts with Vimentin to activate the PI3K/AKT pathway and promotes breast cancer pathogenesis. . 11:10697-10710. https://doi.org/10.18632/aging.102485
Alberro A, Osorio-Querejeta I, Sepúlveda L, Fernández-Eulate G, Mateo-Abad M, Muñoz-Culla M, Carregal-Romero S, Matheu A, Vergara I, López de Munain A, Sáenz-Cuesta M, Otaegui D, . T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians. . 11:10723-10741. https://doi.org/10.18632/aging.102517
Nisar S, Hashem S, Bhat AA, Syed N, Yadav S, Azeem MW, Uddin S, Bagga P, Reddy R, Haris M, . Association of genes with phenotype in autism spectrum disorder. . 11:10742-10770. https://doi.org/10.18632/aging.102473
Zhavoronkov A, Li R, Ma C, Mamoshina P, . Deep biomarkers of aging and longevity: from research to applications. . 11:10771-10780. https://doi.org/10.18632/aging.102475
Li F, Sun L, Wu D, Gao H, Min Z, . Correction for: Proteomics-based identification of different training adaptations of aged skeletal muscle following long-term high-intensity interval and moderate-intensity continuous training in aged rats. . 11:10781-10782. https://doi.org/10.18632/aging.102596