Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 10, Issue 11

November 2018
pp 3042—3627

About the Cover

The cover for issue 11 of Aging features Figure 1 "Relationship between aging and diseases" from Blagosklonny

Explore This Issue

Editorials

IDOL in metabolic, neurodegenerative and cardiovascular disease

Nienke M. van Loon, Patrick C.N. Rensen, Noam Zelcer,

https://doi.org/10.18632/aging.101597 pp 3042—3043

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MINOCA: current perspectives

Rocco A. Montone, Michele Russo, Giampaolo Niccoli,

https://doi.org/10.18632/aging.101618 pp 3044—3045

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Cardiovascular disease, inflammation, and mRNA stability

Allison B. Herman, Michael V. Autieri,

https://doi.org/10.18632/aging.101619 pp 3046—3047

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Implications of aging in the treatment of complex arrhythmias

Sofia Chatzidou, Georgios Georgiopoulos, Christos Kontogiannis,

https://doi.org/10.18632/aging.101620 pp 3048—3049

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Spatial navigation, aging and Alzheimer’s disease

Jan Laczó, Martina Parizkova, Scott D. Moffat,

https://doi.org/10.18632/aging.101634 pp 3050—3051

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Filamin A modulates platelet function

Jose J. Lopez, Isaac Jardin, Juan A. Rosado,

https://doi.org/10.18632/aging.101635 pp 3052—3053

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Do platelets LINE up for aging?

Hansjörg Schwertz, Matthew T. Rondina,

https://doi.org/10.18632/aging.101636 pp 3054—3055

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Blood pressure lowering in acute intracerebral hemorrhage

Olalla Pancorbo, David Rodriguez-Luna,

https://doi.org/10.18632/aging.101637 pp 3056—3057

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The heterogeneity within Alzheimer's disease

Daniel Ferreira, Lars-Olof Wahlund, Eric Westman,

https://doi.org/10.18632/aging.101638 pp 3058—3060

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Inflammatory markers and mediators in heart disease

Ana M. Valdes, Cristina Menni,

https://doi.org/10.18632/aging.101640 pp 3061—3062

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APP signaling in Alzheimer’s disease

Elena Anahi Bignante, Alfredo Lorenzo,

https://doi.org/10.18632/aging.101641 pp 3063—3064

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Aging clocks: disrupted circadian rhythms

Aiste Steponenaite, Stephany M. Biello, Gurprit S. Lall,

https://doi.org/10.18632/aging.101642 pp 3065—3066

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Theory Article

Disease or not, aging is easily treatable

Mikhail V. Blagosklonny,

https://doi.org/10.18632/aging.101647 pp 3067—3078

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Meeting Report

Aging and drug discovery

Daniela Bakula, Alexander M. Aliper, Polina Mamoshina, Michael A. Petr, Amanuel Teklu, Joseph A. Baur, Judith Campisi, Collin Y. Ewald, Anastasia Georgievskaya, Vadim N. Gladyshev, Olga Kovalchuk, Dudley W. Lamming, Martijn S. Luijsterburg, Alejandro Martín-Montalvo, Stuart Maudsley, Garik V. Mkrtchyan, Alexey Moskalev, S. Jay Olshansky, Ivan V. Ozerov, Alexander Pickett, Michael Ristow, Alex Zhavoronkov, Morten Scheibye-Knudsen,

https://doi.org/10.18632/aging.101646 pp 3079—3088

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Research Papers

Glucose negatively affects Nrf2/SKN-1-mediated innate immunity in C. elegans

Le Li, Yi Chen, Changchi Chenzhao, Shuxiang Fu, Qumiao Xu, Jinfeng Zhao,

https://doi.org/10.18632/aging.101610 pp 3089—3103

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Inactivation of glycogen synthase kinase-3α is required for mitochondria-mediated apoptotic germ cell phagocytosis in Sertoli cells

Yabin Gong, Zhilong Zhang, Zhanglin Chang, Hao Zhou, Ruqian Zhao, Bin He,

https://doi.org/10.18632/aging.101614 pp 3104—3116

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Transferrin is responsible for mediating the effects of iron ions on the regulation of anterior pharynx-defective-1α/β and Presenilin 1 expression via PGE₂ and PGD₂ at the early stage of Alzheimer’s Disease

Chen-Di Lu, Ji-Kang Ma, Zheng-Yang Luo, Qun-Xi Tai, Pu Wang, Pei-Pei Guan,

https://doi.org/10.18632/aging.101615 pp 3117—3135

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Egr-1 is involved in coronary microembolization-induced myocardial injury via Bim/Beclin-1 pathway-mediated autophagy inhibition and apoptosis activation

Xian-tao Wang, Xiao-dan Wu, Yuan-xi Lu, Yu-han Sun, Han-hua Zhu, Jia-bao Liang, Wen-kai He, Lang Li,

https://doi.org/10.18632/aging.101616 pp 3136—3147

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BK channel overexpression on plasma membrane of fibroblasts from Hutchinson-Gilford progeria syndrome

Isabella Zironi, Entelë Gavoçi, Giovanna Lattanzi, Angela Virelli, Fabrizio Amorini, Daniel Remondini, Gastone Castellani,

https://doi.org/10.18632/aging.101621 pp 3148—3160

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AMPKα pathway involved in hepatic triglyceride metabolism disorder in diet-induced obesity mice following Escherichia coli Infection

Jing Fang, Fengyuan Wang, Hetao Song, Zhengyi Wang, Zhicai Zuo, Hengmin Cui, Yiping Jia, Junliang Deng, Shumin Yu, Yanchun Hu, Liuhong Shen, Xiaoping Ma, Zhihua Ren, Liping Gou,

https://doi.org/10.18632/aging.101623 pp 3161—3172

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Effects of senescent secretory phenotype acquisition on human retinal pigment epithelial stem cells

Raffaella Lazzarini, Michele Nicolai, Vittorio Pirani, Cesare Mariotti, Roberto Di Primio,

https://doi.org/10.18632/aging.101624 pp 3173—3184

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Identification of an energy metabolism-related signature associated with clinical prognosis in diffuse glioma

Zhengui Zhou, Ruoyu Huang, Ruichao Chai, Xiaohong Zhou, Zhiping Hu, Wenbiao Wang, Baoguo Chen, Lintao Deng, Yuqing Liu, Fan Wu,

https://doi.org/10.18632/aging.101625 pp 3185—3209

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Accelerated DNA methylation age and the use of antihypertensive medication among older adults

Xu Gao, Elena Colicino, Jincheng Shen, Allan C. Just, Jamaji C. Nwanaji-Enwerem, Cuicui Wang, Brent Coull, Xihong Lin, Pantel Vokonas, Yinan Zheng, Lifang Hou, Joel Schwartz, Andrea A. Baccarelli,

https://doi.org/10.18632/aging.101626 pp 3210—3228

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Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats

Maibouge Tanko Mahamane Salissou, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Fang Huang, Yuman Wang, Zhendong Xu, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Bin Zhang, Xiaochuan Wang,

https://doi.org/10.18632/aging.101627 pp 3229—3248

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PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging

Eugene Bobrov, Anastasia Georgievskaya, Konstantin Kiselev, Artem Sevastopolsky, Alex Zhavoronkov, Sergey Gurov, Konstantin Rudakov, Maria del Pilar Bonilla Tobar, Sören Jaspers, Sven Clemann,

https://doi.org/10.18632/aging.101629 pp 3249—3259

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Overexpression of CBS and CSE genes affects lifespan, stress resistance and locomotor activity in Drosophila melanogaster

Mikhail Shaposhnikov, Ekaterina Proshkina, Lyubov Koval, Nadezhda Zemskaya, Alex Zhavoronkov, Alexey Moskalev,

https://doi.org/10.18632/aging.101630 pp 3260—3272

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Spindle pole body component 25 regulates stemness of prostate cancer cells

Feilun Cui, Huaming Tang, Jian Tan, Jianpeng Hu,

https://doi.org/10.18632/aging.101631 pp 3273—3282

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Uncoupling protein 4 (UCP4) gene variability in neurodegenerative disorders: further evidence of association in Frontotemporal dementia

Alberto Montesanto, Paolina Crocco, Serena Dato, Silvana Geracitano, Francesca Frangipane, Rosanna Colao, Raffaele Maletta, Giuseppe Passarino, Amalia C. Bruni, Giuseppina Rose,

https://doi.org/10.18632/aging.101632 pp 3283—3293

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Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

Bela Ozsvari, John R. Nuttall, Federica Sotgia, Michael P. Lisanti,

https://doi.org/10.18632/aging.101633 pp 3294—3307

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ZNF185 is a p53 target gene following DNA damage

Artem Smirnov, Angela Cappello, Anna Maria Lena, Lucia Anemona, Alessandro Mauriello, Nicola Di Daniele, Margherita Annicchiarico-Petruzzelli, Gerry Melino, Eleonora Candi,

https://doi.org/10.18632/aging.101639 pp 3308—3326

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Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging

Annunziata N. Crupi, Jordan S. Nunnelee, David J. Taylor, Amandine Thomas, Jean-Philippe Vit, Celine E. Riera, Roberta A. Gottlieb, Helen S. Goodridge,

https://doi.org/10.18632/aging.101643 pp 3327—3352

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LOC134466 methylation promotes oncogenesis of endometrial carcinoma through LOC134466/hsa-miR-196a-5p/TAC1 axis

Hai Xu, Yuan Sun, Zhen Ma, Xin Xu, Lili Qin, Baoping Luo,

https://doi.org/10.18632/aging.101644 pp 3353—3370

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LncRNA CDKN2BAS predicts poor prognosis in patients with hepatocellular carcinoma and promotes metastasis via the miR-153-5p/ARHGAP18 signaling axis

Junzheng Chen, Xitian Huang, Weijun Wang, Hongcheng Xie, Jianfeng Li, Zhenfen Hu, Zhijian Zheng, Huiyong Li, Lingfang Teng,

https://doi.org/10.18632/aging.101645 pp 3371—3381

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Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans

Christopher J. Gaffney, Amelia Pollard, Thomas F. Barratt, Dumitru Constantin-Teodosiu, Paul L. Greenhaff, Nathaniel J. Szewczyk,

https://doi.org/10.18632/aging.101654 pp 3382—3396

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Cell cycle-dependent and -independent telomere shortening accompanies murine brain aging

Quratul Ain, Christian Schmeer, Diane Penndorf, Mike Fischer, Tzvetanka Bondeva, Martin Förster, Ronny Haenold, Otto W Witte, Alexandra Kretz,

https://doi.org/10.18632/aging.101655 pp 3397—3420

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miR-150-5p suppresses tumor progression by targeting VEGFA in colorectal cancer

Xiaoxiang Chen, Xueni Xu, Bei Pan, Kaixuan Zeng, Mu Xu, Xiangxiang Liu, Bangshun He, Yuqin Pan, Huiling Sun, Shukui Wang,

https://doi.org/10.18632/aging.101656 pp 3421—3437

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Trends in stroke incidence among elderly low-income residents of rural China: a population-based study from 1992 to 2016

Hongyan Lu, Zaiyu Guo, Jie Liu, Heliang Zhang, Wei Zhao, Yanan Wu, Jingxian Ni, Wei Liu, Jun Tu, Jinghua Wang, Xianjia Ning, Jianning Zhang,

https://doi.org/10.18632/aging.101657 pp 3438—3449

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Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients

Gang Ning, Yan-Lin Huang, Li-Min Zhen, Wen-Xiong Xu, Qian Jiao, Fang-Ji Yang, Li-Na Wu, Yong-Yuan Zheng, Jie Song, Yen-Sheng Wang, Chan Xie, Liang Peng,

https://doi.org/10.18632/aging.101658 pp 3450—3473

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TGF-β induces corneal endothelial senescence via increase of mitochondrial reactive oxygen species in chronic corneal allograft failure

Zhiyuan Li, Ting Liu, Junwei Ma, Qie Guo, Liang Ma, Qiulan Lv, Yan Jiang, Chao Wei, Jisheng Zhang,

https://doi.org/10.18632/aging.101659 pp 3474—3485

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Phosphatidylcholine could protect the defect of zearalenone exposure on follicular development and oocyte maturation

Fang-Nong Lai, Xue-Lian Liu, Na Li, Rui-Qian Zhang, Yong Zhao, Yan-Zhong Feng, Charles Martin Nyachoti, Wei Shen, Lan Li,

https://doi.org/10.18632/aging.101660 pp 3486—3506

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Angiopoietin-1 and ανβ3 integrin peptide promote the therapeutic effects of L-serine in an amyotrophic lateral sclerosis/Parkinsonism dementia complex model

Hua-ying Cai, Ke-wei Tian, Yuan-yuan Zhang, Hong Jiang, Shu Han,

https://doi.org/10.18632/aging.101661 pp 3507—3527

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Positive association of familial longevity with the moderate-high HDL-C concentration in Bama Aging Study

Jian Wang, Liwei Shi, Yunfeng Zou, Jiexia Tang, Jiansheng Cai, Yi Wei, Jian Qin, Zhiyong Zhang,

https://doi.org/10.18632/aging.101663 pp 3528—3540

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Cell and tissue type independent age-associated DNA methylation changes are not rare but common

Tianyu Zhu, Shijie C Zheng, Dirk S. Paul, Steve Horvath, Andrew E. Teschendorff,

https://doi.org/10.18632/aging.101666 pp 3541—3557

View Abstract PDF Full-Text How to Cite Special Collection on Steve Horvath's Publications in Aging (Albany NY)

Myoblasts rely on TAp63 to control basal mitochondria respiration

Veronica Ciuffoli, Anna Maria Lena, Alessandra Gambacurta, Gerry Melino, Eleonora Candi,

https://doi.org/10.18632/aging.101668 pp 3558—3573

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Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases

Elena Y. Kochetkova, Galina I. Blinova, Olga A. Bystrova, Marina G. Martynova, Valeriy A. Pospelov, Tatiana V. Pospelova,

https://doi.org/10.18632/aging.101686 pp 3574—3589

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Reviews

The senescent cell epigenome

Na Yang, Payel Sen,

https://doi.org/10.18632/aging.101617 pp 3590—3609

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Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms

Elena Chiappini, Martina Bianconi, Annalisa Dalzini, Maria Raffaella Petrara, Luisa Galli, Carlo Giaquinto, Anita De Rossi,

https://doi.org/10.18632/aging.101622 pp 3610—3625

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Corrections

Correction: MicroRNA-939 inhibits cell proliferation via targeting LRSAM1 in Hirschsprung’s disease

Guanglin Chen, Chunxia Du, Ziyang Shen, Lei Peng, Hua Xie, Rujin Zang, Hongxing Li, Yankai Xia, Weibing Tang,

https://doi.org/10.18632/aging.101650 pp 3626

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Correction: CD40L promotes development of acute aortic dissection via induction of inflammation and impairment of endothelial cell function

Lu Han, Lu Dai, Yuan-Fei Zhao, Hai-Yang Li, Ou Liu, Feng Lan, Wen-Jian Jiang, Hong-Jia Zhang,

https://doi.org/10.18632/aging.101651 pp 3627

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